Abstract
Photothermal therapy (PTT) is emerging as an effective treatment for superficial carcinoma. A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion efficiency. Aiming to address this challenge, we develop a series of multi-arylpyrrole derivatives with different donors that contain different multi-rotor structures to explore highly efficient PTT photosensitizers. Among these multi-arylpyrrole derivatives, MAP4-FE nanoparticles with a small size of their donor groups and better-donating ability exhibit a high photothermal conversion efficiency (up to 72%) when they are encapsulated by an amphiphilic polymer. As a result, the MAP4-FE nanoparticles have shown satisfactory PTT effects on in vivo tumor eradication under the guidance of photoacoustic signals. The findings of this study provide significant insights for the development of high-efficiency PTT photosensitizers for cancer treatment by making full use of the nonradiative decay of small size donors as rotors.
Similar content being viewed by others
References
Kalbasi A, Komar C, Tooker GM, Liu M, Lee JW, Gladney WL, Ben-Josef E, Beatty GL. Clin Cancer Res, 2017, 23: 137–148
Sullivan LB, Gui DY, Vander Heiden MG. Nat Rev Cancer, 2016, 16: 680–693
De Ruysscher D, Niedermann G, Burnet NG, Siva S, Lee AWM, Hegi-Johnson F. Nat Rev Dis Primers, 2019, 5: 13
Shi Y, Lammers T. Acc Chem Res, 2019, 52: 1543–1554
Yang K, Yu G, Tian R, Zhou Z, Deng H, Li L, Yang Z, Zhang G, Liu D, Wei J, Yue L, Wang R, Chen X. Adv Funct Mater, 2021, 31: 2008078
Villanueva MT. Nat Rev Drug Discov, 2018, 17: 619
Son S, Kim JH, Wang X, Zhang C, Yoon SA, Shin J, Sharma A, Lee MH, Cheng L, Wu J, Kim JS. Chem Soc Rev, 2020, 49: 3244–3261
Sun L, Xiong Z, Shen F, Wang Z, Liu Z. Sci China Chem, 2021, 64: 719–733
You Q, Zhang K, Liu J, Liu C, Wang H, Wang M, Ye S, Gao H, Lv L, Wang C, Zhu L, Yang Y. Adv Sci, 2020, 7: 1903341
Hong G, Antaris AL, Dai H. Nat Biomed Eng, 2017, 1: 0010
Wang B, Kostarelos K, Nelson BJ, Zhang L. Adv Mater, 2021, 33: 2002047
Exner RM, Cortezon-Tamarit F, Pascu SI. Angew Chem Int Ed, 2021, 60: 6230–6241
Song N, Zhang Z, Liu P, Dai D, Chen C, Li Y, Wang L, Han T, Yang Y-, Wang D, Tang BZ. Adv Funct Mater, 2021, 31: 2009924
Huang X, Zhang W, Guan G, Song G, Zou R, Hu J. Acc Chem Res, 2017, 50: 2529–2538
Xi D, Xiao M, Cao J, Zhao L, Xu N, Long S, Fan J, Shao K, Sun W, Yan X, Peng X. Adv Mater, 2020, 32: 1907855
Fan W, Yung B, Huang P, Chen X. Chem Rev, 2017, 117: 13566–13638
Liu Y, Bhattarai P, Dai Z, Chen X. Chem Soc Rev, 2019, 48: 2053–2108
Li X, Liu L, Li S, Wan Y, Chen JX, Tian S, Huang Z, Xiao YF, Cui X, Xiang C, Tan Q, Zhang XH, Guo W, Liang XJ, Lee CS. ACS Nano, 2019, 13: 12901–12911
Ni JS, Zhang X, Yang G, Kang T, Lin X, Zha M, Li Y, Wang L, Li K. Angew Chem Int Ed, 2020, 59: 11298–11302
Li B, Lu L, Zhao M, Lei Z, Zhang F. Angew Chem Int Ed, 2018, 57: 7483–7487
Fang H, Chen Y, Wang Y, Geng S, Yao S, Song D, He W, Guo Z. Sci China Chem, 2020, 63: 699–706
Tian R, Ma H, Yang Q, Wan H, Zhu S, Chandra S, Sun H, Kiesewetter DO, Niu G, Liang Y, Chen X. Chem Sci, 2019, 10: 326–332
Li Y, Liu Y, Li Q, Zeng X, Tian T, Zhou W, Cui Y, Wang X, Cheng X, Ding Q, Wang X, Wu J, Deng H, Li Y, Meng X, Deng Z, Hong X, Xiao Y. Chem Sci, 2020, 11: 2621–2626
Lin J, Li Q, Zeng X, Chen Z, Ding Q, Li Y, Zhou H, Meng X, Chen D, Deng Z, Hong X, Xiao Y. Sci China Chem, 2020, 63: 766–770
Wu W, Yang Y, Yang Y, Yang Y, Zhang K, Guo L, Ge H, Chen X, Liu J, Feng H. Small, 2019, 15: 1805549
Zha M, Lin X, Ni JS, Li Y, Zhang Y, Zhang X, Wang L, Li K. Angew Chem Int Ed, 2020, 59: 23268–23276
Zhang Z, Xu W, Kang M, Wen H, Guo H, Zhang P, Xi L, Li K, Wang L, Wang D, Tang BZ. Adv Mater, 2020, 32: 2003210
Li S, Deng Q, Zhang Y, Li X, Wen G, Cui X, Wan Y, Huang Y, Chen J, Liu Z, Wang L, Lee CS. Adv Mater, 2020, 32: 2001146
Zhang Y, Song J, Qu J, Qian PC, Wong WY. Sci China Chem, 2021, 64: 341–357
He S, Song J, Qu J, Cheng Z. Chem Soc Rev, 2018, 47: 4258–4278
Fang Y, Shang J, Liu D, Shi W, Li X, Ma H. J Am Chem Soc, 2020, 142: 15271–15275
Young IS, Thornton PD, Thompson A. Nat Prod Rep, 2010, 27: 1801–1839
Estévez V, Villacampa M, Menéndez JC. Chem Soc Rev, 2014, 43: 4633–4657
Fathi P, Pan D. Nanomedicine, 2020, 15: 2493–2515
Ren F, Liu P, Gao Y, Shi J, Tong B, Cai Z, Dong Y. Mater Chem Front, 2019, 3: 57–63
Lei Y, Liu Q, Dong L, Cai Z, Shi J, Zhi J, Tong B, Dong Y. Chem Eur J, 2018, 24: 14269–14274
Lei Y, Dai W, Liu Z, Guo S, Cai Z, Shi J, Zheng X, Zhi J, Tong B, Dong Y. Mater Chem Front, 2019, 3: 284–291
Ren F, Shi J, Tong B, Cai Z, Dong Y. Mater Chem Front, 2019, 3: 2072–2076
Qu J, Ren F, Shi J, Tong B, Cai Z, Dong Y. Chem Eur J, 2020, 26: 14947–14953
Dong L, Shang G, Shi J, Zhi J, Tong B, Dong Y. J Phys Chem C, 2017, 121: 11658–11664
Xu F, Ge H, Xu N, Yang C, Yao Q, Long S, Sun W, Fan J, Xu X, Peng X. Sci China Chem, 2021, 64: 488–498
Xu W, Wang D, Tang BZ. Angew Chem Int Ed, 2021, 60: 7476–7487
He Y, Cao Y, Wang Y. Asian J Org Chem, 2018, 7: 2201–2212
Liu Z, Zou H, Zhao Z, Zhang P, Shan GG, Kwok RTK, Lam JWY, Zheng L, Tang BZ. ACS Nano, 2019, 13: 11283–11293
Li H, Yao Q, Pu Z, Chung J, Ge H, Shi C, Xu N, Xu F, Sun W, Du J, Fan J, Wang J, Yoon J, Peng X. Sci China Chem, 2021, 64: 499–508
Won M, Koo S, Li H, Sessler JL, Lee JY, Sharma A, Kim JS. Angew Chem Int Ed, 2021, 60: 3196–3204
Zheng X, Peng Q, Zhu L, Xie Y, Huang X, Shuai Z. Nanoscale, 2016, 8: 15173–15180
Zhang Y, Xu H, Xu W, Zhang C, Shi J, Tong B, Cai Z, Dong Y. Sci China Chem, 2019, 62: 1393–1397
Acknowledgements
This work was financially supported by the National Natural Science Foundation of China (21875019, 21803007, 21975020, 51803009), the National Key Research and Development Program of China (2018YFA0901800), the Department of Science and Technology of Guangdong Province (2019ZT08Y191), and the Shenzhen Science and Technology Program (JSGG20200225151916021).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Ren, F., Li, Z., Li, K. et al. Donor strategy for promoting nonradiative decay to achieve an efficient photothermal therapy for treating cancer. Sci. China Chem. 64, 1530–1539 (2021). https://doi.org/10.1007/s11426-021-1055-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11426-021-1055-0