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CuO/Cu2O nanowire array photoelectrochemical biosensor for ultrasensitive detection of tyrosinase

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Abstract

Photoelectrochemical (PEC) biosensors have shown great promise in bioanalysis and diagnostic applications in recent years. In this work, the CuO/Cu2O nanowire array (CuO/Cu2O Nanowire) supported on copper foam was prepared as a photocathode for detection of tyrosinase though quinone-chitosan conjugation chemistry method. The in-situ generated quinones that were the catalytic product of tyrosinase acted as electron acceptors, which were captured by the chitosan deposited on the surface of the electrode. Direct immobilization of electron acceptor on the electrode surface improved the photocurrent conversion efficiency and thus sensitivity. The as-prepared biosensor can realize a rapid response in a wide linear range of 0.05 U/mL to 10 U/mL with the detection limit as low as 0.016 U/mL of tyrosinase. The current work provides a new perspective to design and develop highly sensitive and selective PEC biosensor.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21775089), the Outstanding Youth Foundation of Shandong Province (ZR2017JL010), the Key Research and Development Program of Jining City (2018ZDGH032) and Taishan scholar of Shandong Province (tsqn201909106). Thanks eceshi (http://www.eceshi.cn) for XPS analysis.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, China

    Xiaoxi Guo, Jinghua Wu, Lian Xia, Meihao Xiang & Fengli Qu

  2. Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China

    Jinghong Li

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  1. Xiaoxi Guo
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  2. Jinghua Wu
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  3. Lian Xia
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  4. Meihao Xiang
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  5. Fengli Qu
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Correspondence to Fengli Qu.

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Guo, X., Wu, J., Xia, L. et al. CuO/Cu2O nanowire array photoelectrochemical biosensor for ultrasensitive detection of tyrosinase. Sci. China Chem. 63, 1012–1018 (2020). https://doi.org/10.1007/s11426-020-9717-8

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  • DOI: https://doi.org/10.1007/s11426-020-9717-8

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