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An efficient and facile synthesis of N-Cbz-β-aminoalkanesulfonamides

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Abstract

An efficient method for the synthesis of N-Cbz-β-aminoalkanesulfonamides was described. N-Cbz-β-aminoalkanesulfona-mides were readily prepared in good yields from a variety of amino alcohols, including optically active ones, via N-Cbz protection with benzyl chloroformate, Mitsunobu esterification reaction with thiolacetic acid, N-chlorosuccinimide oxidation, and ammonolysis process.

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Authors and Affiliations

  1. State Key Laboratory of Chemical Resource Engineering; Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing, 100029, China

    FanHua Meng, Ning Chen & JiaXi Xu

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  1. FanHua Meng
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  2. Ning Chen
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  3. JiaXi Xu
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Correspondence to JiaXi Xu.

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Meng, F., Chen, N. & Xu, J. An efficient and facile synthesis of N-Cbz-β-aminoalkanesulfonamides. Sci. China Chem. 55, 2548–2553 (2012). https://doi.org/10.1007/s11426-012-4607-9

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  • DOI: https://doi.org/10.1007/s11426-012-4607-9

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