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Conjugated polyelectrolytes for label-free visual detection of heparin

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Abstract

Conjugated polyelectrolytes (CPEs), with electron-delocalized backbones and charged ionic side chains, are unique sensory materials for the construction of optical biosensors. In this feature article, CPE-based visual detection of heparin is summarized. Three CPE-based heparin probes, including ratiometric, light-up and colormetric probes, are discussed in terms of molecular design, detection selectivity and quantification capability. The work summarized here provides fundamental guidelines for CPE-based label-free visual sensing.

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Authors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117576, Singapore

    KanYi Pu, RuoYu Zhan, Jing Liang & Bin Liu

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  1. KanYi Pu
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  2. RuoYu Zhan
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  4. Bin Liu
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Correspondence to Bin Liu.

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Pu, K., Zhan, R., Liang, J. et al. Conjugated polyelectrolytes for label-free visual detection of heparin. Sci. China Chem. 54, 567–574 (2011). https://doi.org/10.1007/s11426-011-4241-y

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