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Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier

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Abstract

One-pot synthesis of magnetic nanogels with excellent biocompatibility via the photochemical method is reported in this paper. Poly(PEGMA) modified superparamagnetic nanogels (poly(PEGMA) magnetic nanogels) were synthesized by in-situ polymerization using poly(ethylene glycol) methacrylate (PEGMA) as the monomer and N, N′-methylene-bis-(acrylamide) (MBA) as the cross-linking agent in magnetite aqueous suspension under UV irradiation. The surface functional groups and components of magnetic nanogels were analyzed by Fourier transform infrared spectroscopy (FTIR) and a thermogravimetric analyzer (TGA). The results indicated that the poly(PEGMA) magnetic nanogels were synthesized successfully by coating poly(PEGMA) on the Fe3O4 nanoparticles under UV irradiation, and the Fe3O4 nanoparticles content in this nanogels was above 50 wt%. The morphology, size, zeta-potential and magnetic property were also characterized. The magnetic nanogels had a nearly spherical shape and core-shell structure, the average size in aqueous system measured by photon correlation spectroscopy (PCS) was 68.4 nm, which was much bigger than that in the dry state, the nanogels behaved superparamagnetically with saturated magnetization of 58.6 emu/g, and the zeta-potential was −16.3–−17.3 mV at physiological pH (6.8–7.4) which could help to maintain stability in blood. The preliminary application as drug carrier was made and the doxorubicin-loaded magnetic nanogels had an excellent property in slow-release. The experiment indicated that the magnetic nanogel was an ideal candidate carrier in target drug delivery systems and other biomedical application.

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Authors and Affiliations

  1. Dezhou University, Dezhou, 253023, China

    HanWen Sun, LianYing Zhang, XinJun Zhu, ChunYan Kong & CunLan Zhang

  2. Chinese Academy of Sciences, Shanghai, 201800, China

    SiDe Yao

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  1. HanWen Sun
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  2. LianYing Zhang
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  3. XinJun Zhu
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  4. ChunYan Kong
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  5. CunLan Zhang
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  6. SiDe Yao
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Correspondence to HanWen Sun or SiDe Yao.

Additional information

Supported by the Natural Science Foundation of Shandong Province (Grant No. Q2006F01), Scientific and Technological Project of Shandong Province (Grant No. 2007GG3WZ02066) and Scientific and Technological Project of Department of Education, Shandong (Grant No. J07WC01)

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Sun, H., Zhang, L., Zhu, X. et al. Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier. Sci. China Ser. B-Chem. 52, 69–75 (2009). https://doi.org/10.1007/s11426-008-0136-y

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  • DOI: https://doi.org/10.1007/s11426-008-0136-y

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