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Noise-induced coherent switch

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Abstract

Taking the famous genetic toggle switch as an example, we numerically investigated the effect of noise on bistability. We found that extrinsic noise resulting from stochastic fluctuations in synthesis and degradation rates and from the environmental fluctuation in gene regulatory processes can induce coherent switch, and that there is an optimal noise intensity such that the noise not only can induce this switch, but also can amplify a weak input signal. In addition, we found that the intrinsic noise introduced through the Poisson τ-leap algorithm cannot induce such a switch.

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Authors and Affiliations

  1. School of Life Science, Sun Yat-Sen University, Guangzhou, 510275, China

    TianShou Zhou

  2. School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou, 510275, China

    ZhanJiang Yuan, JiaJun Zhang & TianShou Zhou

Authors
  1. ZhanJiang Yuan
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  2. JiaJun Zhang
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  3. TianShou Zhou
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Correspondence to TianShou Zhou.

Additional information

Supported by the National Distinguished PhD Dissertations (200521) and the National Natural Science Foundation of China (Grant No. 60736208)

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Yuan, Z., Zhang, J. & Zhou, T. Noise-induced coherent switch. Sci. China Ser. B-Chem. 51, 562–569 (2008). https://doi.org/10.1007/s11426-007-0134-5

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  • DOI: https://doi.org/10.1007/s11426-007-0134-5

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