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Structures of triterpenoids from the leaves of Lansium domesticum

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Abstract

From the methanolic extract of the leaves of Lansium domesticum, three new onoceranoid-type triterpenoids, lansium acids X–XII and a new cycloartane-type triterpene, lansium acid XIII, were isolated. The chemical structures of the isolated new compounds were elucidated on the basis of chemical/physicochemical evidence. For new onoceranoid-type triterpenoids, the absolute configurations were established by comparison of experimental and predicted electronic circular dichroism (ECD) data. The isolated onoceranoid-type triterpenoids showed antimutagenic effects in the Ames assay against 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1).

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Acknowledgements

This research was supported by JSPS KAKENHI grant number JP17K15473.

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Authors and Affiliations

  1. Department of Public Health, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan

    Takahiro Matsumoto, Takahiro Kitagawa, Daisuke Imahori & Tetsushi Watanabe

  2. Faculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki, 859-3298, Japan

    Tomoe Ohta & Tatsusada Yoshida

  3. Forest Department Sarawak, Wisma Sumber Alam, Jalan Stadium, Petra Jaya, 93660, Kuching, Sarawak, Malaysia

    Stephen Teo & Haji Sapuan bin Ahmad

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  1. Takahiro Matsumoto
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  2. Takahiro Kitagawa
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  3. Tomoe Ohta
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  4. Tatsusada Yoshida
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  5. Daisuke Imahori
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  6. Stephen Teo
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  7. Haji Sapuan bin Ahmad
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  8. Tetsushi Watanabe
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Correspondence to Tetsushi Watanabe.

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Matsumoto, T., Kitagawa, T., Ohta, T. et al. Structures of triterpenoids from the leaves of Lansium domesticum. J Nat Med 73, 727–734 (2019). https://doi.org/10.1007/s11418-019-01319-2

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  • DOI: https://doi.org/10.1007/s11418-019-01319-2

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