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Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii

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Abstract

Nine new monomacrolide sesquiterpene pyridine alkaloids, macroregelines A–I (1–9), were isolated from the stems of Tripterygium regelii, along with a known alkaloid, tripfordine B. The structures of all the isolated compounds were characterized by extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic analyses, as well as high-resolution electrospray-ionization mass spectrometry (HRESIMS) data. Compounds 4, 5, 6, and 8 showed antiproliferative effect on human rheumatoid arthritis synovial cell line MH7A at concentration of 20 μM, reducing their viability by 7.5, 18.0, 9.0, and 18.2 %, respectively.

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Acknowledgements

This research work was financially supported by Macao Science and Technology Development Fund (grant no. 056/2013/A2 and 063/2011/A3).

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Authors and Affiliations

  1. State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China

    Dongsheng Fan, Ting Li, Zhiyuan Zheng, Guo-Yuan Zhu, Xiaojun Yao, Zhi-Hong Jiang & Li-Ping Bai

  2. The First Affiliated Hospital of Guiyang University of Chinese Medicine, Guiyang University of Chinese Medicine, Guiyang, 550001, China

    Dongsheng Fan

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  1. Dongsheng Fan
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  2. Ting Li
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  3. Zhiyuan Zheng
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Correspondence to Zhi-Hong Jiang or Li-Ping Bai.

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Fan, D., Li, T., Zheng, Z. et al. Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii. J Nat Med 73, 23–33 (2019). https://doi.org/10.1007/s11418-018-1232-8

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  • DOI: https://doi.org/10.1007/s11418-018-1232-8

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