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Terpenoids from Vitex trifolia and their anti-inflammatory activities

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Abstract

A new diterpenoid glucoside, (3S,5S,6S,8R,9R,10S)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-O-β-D-glucopyranoside (1), and a new iridoid glucoside, (1S, 5S,6R,9R)-10-O-p-hydroxybenzoyl-5,6β-dihydroxy iridoid 1-O-β-D-glucopyranoside (2), along with six known compounds (3-8) were isolated from Vitex trifolia L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds 2, 4, 5, and 7 showed moderate inhibitory activities with IC50 values of 90.05, 88.51, 87.26, and 76.06 μM, respectively.

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Author notes

  1. Fengyan Bao and Ruotian Tang contributed equally to this work.

Authors and Affiliations

  1. Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China

    Fengyan Bao, Li Cheng, Cuiyun Zhang, Chongyue Qiu, Ting Yuan, Lihan Zhu, Hua Li & Lixia Chen

  2. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Ruotian Tang & Hua Li

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  1. Fengyan Bao
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  2. Ruotian Tang
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  3. Li Cheng
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  4. Cuiyun Zhang
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  5. Chongyue Qiu
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  6. Ting Yuan
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  7. Lihan Zhu
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  8. Hua Li
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  9. Lixia Chen
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Correspondence to Hua Li or Lixia Chen.

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Bao, F., Tang, R., Cheng, L. et al. Terpenoids from Vitex trifolia and their anti-inflammatory activities. J Nat Med 72, 570–575 (2018). https://doi.org/10.1007/s11418-018-1178-x

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  • DOI: https://doi.org/10.1007/s11418-018-1178-x

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