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Cholinesterase-inhibitory diterpenoids and chemical constituents from aerial parts of Caryopteris mongolica

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Abstract

A diterpenoid diglucoside (12,19-di-O-β-d-glucopyranosyl-11-hydroxyabieta-8,11,13-triene-19-one), isoscutellarein 7-O-[β-d-xylopyranosyl-(1→2)]-β-d-glucopyranoside, isoscutellarein 7-O-[α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside, hypolaetin 7-O-[6″-O-(p-E-coumaroyl)]-β-d-glucopyranoside, hypolaetin 7-O-[6″-O-(E-caffeoyl)]-β-d-glucopyranoside, and 15 known compounds were isolated from aerial parts of the Mongolian medicinal plant Caryopteris mongolica. The cholinesterase-inhibitory activities of the constituents were estimated. The abietane diterpenoids (12-O-demethylcryptojaponol and 6α-hydroxydemethylcryptojaponol) showed potent inhibitory activity against acetylcholinesterase from human erythrocytes and electric eel, and against butyrylcholinesterase from horse serum.

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Acknowledgments

We thank Mr S. Sato and Mr T. Matsuki, Tohoku Pharmaceutical University, for assisting with the MS measurements. This work was supported by grants from the Kanae Foundation for the promotion of medical science and JSPS KAKENHI Grant Number 26860068. This work is partially supported by the Honda Foundation of Japan.

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Authors and Affiliations

  1. Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai, 981-8558, Japan

    Toshihiro Murata, Erdenechimeg Selenge, Saki Oikawa, Keita Ageishi, Kenroh Sasaki & Fumihiko Yoshizaki

  2. School of Engineering and Applied Sciences, National University of Mongolia, POB-617, Ulaanbaatar-46a, Mongolia

    Javzan Batkhuu

  3. Monos University, Sonsgolon’s Road, Street 4/A, 20th Khoroo, Songinokhairkhan District, Ulaanbaatar, Mongolia

    Erdenechimeg Selenge

Authors
  1. Toshihiro Murata
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  2. Erdenechimeg Selenge
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  3. Saki Oikawa
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  4. Keita Ageishi
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  5. Javzan Batkhuu
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  6. Kenroh Sasaki
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  7. Fumihiko Yoshizaki
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Correspondence to Toshihiro Murata.

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Murata, T., Selenge, E., Oikawa, S. et al. Cholinesterase-inhibitory diterpenoids and chemical constituents from aerial parts of Caryopteris mongolica . J Nat Med 69, 471–478 (2015). https://doi.org/10.1007/s11418-015-0908-6

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  • DOI: https://doi.org/10.1007/s11418-015-0908-6

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