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New prenylated flavones from Artocarpus champeden, and their antimalarial activity in vitro

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Abstract

Two new prenylated flavones, artocarpones A and B (1 and 2), and seven known isoprenylated flavonoids, artonin A (3), cycloheterophyllin (4), artoindonesianin E (5), artoindonesianin R (6), heterophyllin (7), heteroflavanone C (8), and artoindonesianin A-2 (9), have been isolated from the stem bark of Artocarpus champeden. Their structures were determined by spectroscopic analysis. Among the compounds isolated, 8 had the most potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with an IC50 value of 1 nmol L−1.

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Acknowledgments

Parts of this work were supported by Grant for Hibah Pascasarjana (no. 748/JO3.2/PG/2005) from The Ministry of Education, Indonesia, and by Grant-in-Aid for International Scientific Research (no. 16406002) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

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Authors and Affiliations

  1. Natural Product Science, Faculty of Pharmacy, Airlangga University, Jalan Darmawangsa Dalam, Surabaya, 60286, Indonesia

    Aty Widyawaruyanti, Maria Nindatu & Noor Cholies Zaini

  2. Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Subehan, Surya Kant Kalauni, Suresh Awale, Yasuhiro Tezuka & Shigetoshi Kadota

  3. Eijkman Institute for Molecular Biology, Jalan Diponegoro 69, Jakarta, 10430, Indonesia

    Din Syafruddin & Puji Budi Setia Asih

Authors
  1. Aty Widyawaruyanti
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  2. Subehan
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  3. Surya Kant Kalauni
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  4. Suresh Awale
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  5. Maria Nindatu
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  6. Noor Cholies Zaini
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  7. Din Syafruddin
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  8. Puji Budi Setia Asih
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  9. Yasuhiro Tezuka
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  10. Shigetoshi Kadota
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Corresponding author

Correspondence to Shigetoshi Kadota.

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Widyawaruyanti, A., Subehan, Kalauni, S.K. et al. New prenylated flavones from Artocarpus champeden, and their antimalarial activity in vitro. J Nat Med 61, 410–413 (2007). https://doi.org/10.1007/s11418-007-0153-8

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  • DOI: https://doi.org/10.1007/s11418-007-0153-8

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