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Relaxing effects of Phellinus gilvus extract and purified ebricoic acid on rat aortic rings

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Abstract

The organic extract of the basidiomycete Phellinus gilvus TMC-1117 showed biphasic vasodilator activity on rat aorta with endothelium. Two lanostane-type triterpenes, eburicoic acid (1) and trametenolic acid B (2), were isolated from the organic extract as major constituents. Compound 1 showed a moderate vasorelaxant effect on rat aorta.

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Acknowledgements

We are grateful to Dr. H. Kasai and Miss N. Kobayashi of Hoshi University for the NMR and mass measurements. This study was supported in part by Hoshi University Science/Technology Frontier Research Base from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan

    Tomoo Hosoe, Toru Iizuka, Yoshihiko Chiba, Takeshi Itabashi, Hiroshi Morita & Ken-ichi Kawai

  2. The Mushroom Research Institute of Japan, 8-1 Hirai-cho, Kiryu, Gunma, 376-0051, Japan

    Takayuki Ishizaki

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  1. Tomoo Hosoe
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  2. Toru Iizuka
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  3. Yoshihiko Chiba
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  4. Takeshi Itabashi
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  5. Hiroshi Morita
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  6. Takayuki Ishizaki
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  7. Ken-ichi Kawai
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Correspondence to Tomoo Hosoe.

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Hosoe, T., Iizuka, T., Chiba, Y. et al. Relaxing effects of Phellinus gilvus extract and purified ebricoic acid on rat aortic rings. J Nat Med 60, 130–134 (2006). https://doi.org/10.1007/s11418-006-0030-x

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  • DOI: https://doi.org/10.1007/s11418-006-0030-x

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