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Sedierung in der gastrointestinalen Endoskopie

Sedation in gastro-intestinal endoscopy

  • CME Weiterbildung · Zertifizierte Fortbildung
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Der Gastroenterologe Aims and scope

Zusammenfassung

Die erste deutsche S3-Leitlinie zur Sedierung in der gastrointestinalen Endoskopie [1] gibt einen strukturierten Überblick darüber, welche Anforderungen an strukturelle und persönliche Qualifikation bereits bestehen, welche Personalressourcen notwendig sind, nach welchen Standards adäquat über die Sedierung aufzuklären ist und wie die Risikostratifizierung der Patienten erfolgt. Neu ist hierbei die durch ein juristisches Fachgutachten von Prof. Dr. Dr. Alexander Ehlers und Partner (s. Homepage der DGVS) und verschiedene ärztliche Fachgruppen befürwortete Delegation einer Sedierung mit Propofol durch nichtärztliches Assistenzpersonal (sog. „nurse administered propofol sedation“, kurz NAPS) innerhalb klar definierter Grenzen. Weltweit einmalig ist, dass diese und auch die anderen Empfehlungen unter Einbindung sämtlicher auf diesem Gebiet relevanter Berufsgruppen, also Gastroenterologen, Anästhesisten, Chirurgen, endoskopisches Assistenzpersonal, Juristen, aber auch Patientenselbsthilfegruppen, etabliert und verabschiedet wurden. Der folgende Beitrag fasst die aktuellen Empfehlungen der Leitlinie zusammen. Auch auswärtige Leitlinien und neuere wissenschaftliche Ergebnisse wurden berücksichtigt.

Abstract

The first German S3 guidelines on sedation in gastro-intestinal endoscopy give a structured overview on which demands on structural and personnel qualifications already exist, which personnel resources are necessary, which standards can be used to adequately clarify sedation and how risk stratification of patients should be carried out. Newly included is the delegation of sedation with propofol to non-medical assistant personnel, so-called nurse-administered propofol sedation (NAPS) within clearly defined limits, advocated by a legal evaluation by Prof. Dr. Dr. Alexander Ehlers and Partner (see homepage of the DGVS) and various medical expert groups. A worldwide premiere is that this and the other recommendations have been established and ratified by all relevant professional groups in this area, i.e. gastro-enterologists, anesthetists, surgeons, endoscope assistant personnel, the legal profession and even patient self-help groups. The following article summarizes the current recommendations of the guidelines and takes guidelines from other countries and new scientific results into consideration.

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Literatur

  1. Riphaus A, Wehrmann T, Weber B et al (2007) S3-Leitlinie Sedierung in der gastrointestinalen Endoskopie. Z Gastroenterol 46: 1298–1330

    Article  Google Scholar 

  2. American Society of Anaesthesiologists (1996) Practice guidelines for sedation and analgesia by non- anaesthesiologists: a report by the American Society of Anaesthesiologists Task Force on Sedation and Analgesia by Non-Anaesthesiologists. Anaesthesiology 84: 459–471

    Article  Google Scholar 

  3. American Society of Gastrointestinal Endoscopy, Lichtenstein DR, Jagannath S, Baron TH et al (2008) Sedation and anesthesia in GI endoscopy. Gastrointest Endosc 68: 815–826

    Article  Google Scholar 

  4. Cohen LB, Wecsler JS, Gaetano JN et al (2006) Endoscopic sedation in the United Staters: results from an nationwide survey. Am J Gastroenterol 101: 967–974

    Article  PubMed  Google Scholar 

  5. Riphaus A, Rabofski M, Wehrmann T (2009) Endoscopic sedation and monitoring practice in Germany: Results from the first nationwide survey. Z Gastroenterol in press

  6. Paspatis GA, Manolaraki MM, Tribonias G et al (2009) Endoscopic sedation in Greece: Results from the first nationwide survey for the Hellenic Foundation of gastroenterology and nutrition. Dig Liver Dis 30: in press

    Google Scholar 

  7. Baudet JS, Borque P, Alarcon-Fernandez O et al (2009) Use of sedation in gastrointestinal endoscopy: a nationwide survey in Spain. Eur J Gastroenterol Hepatol 21: 882–888

    Article  PubMed  Google Scholar 

  8. Heuss LT, Froehlich F, Beglinger C (2005) Changing patterns of sedation and monitoring practice during endoscopy: results of a nationwide survey in Switzerland. Endoscopy 37: 161–166

    Article  CAS  PubMed  Google Scholar 

  9. American Gastroenterological Association, Cohen LB, Delegge MH, Aisenberg G et al (2007) AGA institute review of endoscopic sedation. Gastroenterology 133: 675–701

    Article  CAS  Google Scholar 

  10. Society of American Gastrointestinal and Endoscopic Surgeons, Myers J, Fanelli R, Earle D et al (2009) SAGES guidelines for office endoscopic services. Surg Endosc 23: 1125–1129

    Article  Google Scholar 

  11. German Society of Digestive and Metabolic Diseases, Riphaus A, Wehrmann T, Weber B et al (2009) S3-Guidelines – Sedation for Gastrointestinal Endoscopy. Endoscopy nn: in press

    Google Scholar 

  12. Canadian Association of Gastroenterology, Byrne MF, Chiba N, Singh H, Sadowski DC (2008) Propofol use for sedation during endoscopy in adults: A Canadian Association of Gastroenterology position statement. Can J Gastroenterol 22: 457–459

    Google Scholar 

  13. Austrian Society of Gastroenterology and Hepatology, Schreiber F (2007) ÖGGH guidelines on sedation and monitoring in gastrointestinal endoscopy. Endoscopy 39: 259–262

    Article  Google Scholar 

  14. Spanish Society of Gastrointestinal Endoscopy, Lopez-Roses L (2006) Sedation/analgesia guidelines for endoscopy. Rev Esp Enferm Dig 98: 685–692

    Google Scholar 

  15. American Society of Anesthesiology, Gross JB, Farmington CT, Bailey PL et al (2002) Practice guidelines for sedation and analgesia by non-anesthsiologists. Anesthesiology 96: 1004–1017

    Article  Google Scholar 

  16. Section and Board of Anaesthesiology, European Union of Medical Specialists, Knape JTA et al (2007) Guidelines for sedation and/or analgesia by non-anaesthisiology doctors. Eur J Anaesthesiol 24: 563–567

    Article  CAS  Google Scholar 

  17. Varadarajulu S, Eloubeidi MA, Tamhane A, Wilcox CM (2007) Prospective randomized trial evaluating ketamine for advanced endoscopic procedures in difficult to sedate patients. Aliment Pharmacol Ther 25: 987–997

    Article  CAS  PubMed  Google Scholar 

  18. Van Houten JS, Crane SA, Janardan SK, Wells K (1998) A randomized, prospective, double-blind comparison of midazolam (Versed) and emulsified diazepam (Dizac) for opioid-based, conscious sedation in endoscopic procedures. Am J Gastroenterol 93: 170–174

    Google Scholar 

  19. Macken E, Gevers AM, Hendrickx A, Rutgeerts P (1998) Midazolam versus diazepam in lipid emulsion as conscious sedation for colonoscopy with or without reversal of sedation with flumazenil. Gastrointest Endosc 47: 57–61

    Article  CAS  PubMed  Google Scholar 

  20. Zakko SF, Seifert HA, Gross JB (1999) A comparison of midazolam and diazepam for conscious sedation during colonoscopy in a prospective double-blind study. Gastrointest Endosc 49: 684–689

    Article  CAS  PubMed  Google Scholar 

  21. Froehlich F, Thorens J, Schwizer W et al (1997) Sedation and analgesia for colonoscopy: patient tolerance, pain, and cardiorespiratory parameters. Gastrointest Endosc 45: 1–9

    Article  CAS  PubMed  Google Scholar 

  22. Meining A, Semmler V, Kassem AM et al (2007) The effect of sedation on the quality of upper gastrointestinal endoscopy: an investigator-blinded, randomized study comparing propofol with midazolam. Endoscopy 39: 345–349

    Article  CAS  PubMed  Google Scholar 

  23. Sipe BW, Rex DK, Latinovich D et al (2002) Propofol versus midazolam/meperidine for outpatient colonoscopy: administration by nurses supervised by endoscopists. Gastrointest Endosc 55: 815–825

    Article  PubMed  Google Scholar 

  24. Carlsson U, Grattidge P (1995) Sedation for upper gastrointestinal endoscopy: a comparative study of propofol and midazolam. Endoscopy 27: 240–243

    Article  CAS  PubMed  Google Scholar 

  25. Patterson KW, Casey PB, Murray JP et al (1991) Propofol sedation for outpatient upper gastrointestinal endoscopy: comparison with midazolam. Br J Anaesth 67: 108–111

    Article  CAS  PubMed  Google Scholar 

  26. Riphaus A, Gstettenbauer T, Frenz MB, Wehrmann T (2006) Quality of psychomotor recovery after propofol sedation for routine endoscopy: a randomized and controlled study. Endoscopy 38: 677–683

    Article  CAS  PubMed  Google Scholar 

  27. Vargo JJ, Zuccaro G Jr, Dumot JA et al (2002) Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial. Gastroenterology 123: 373–375

    Article  CAS  Google Scholar 

  28. Weston BR, Chadalawada V, Chalasani N et al (2003) Nurse-administered propofol versus midazolam and meperidine for upper endoscopy in cirrhotic patients. Am J Gastroenterol 98: 2440–2447

    Article  CAS  PubMed  Google Scholar 

  29. Jung M, Hofmann C, Kiesslich R, Brackertz A (2000) Improved sedation in diagnostic and therapeutic ERCP: propofol is an alternative to midazolam. Endoscopy 32: 233–238

    Article  CAS  PubMed  Google Scholar 

  30. Wehrmann T, Kokabpick H, Jacobi V et al (1999) Long-term Results of endoscopic injection of botulinum toxin in elderly achalasic patients with tortuous megaesophagus or epiphrenic diverticulum. Endoscopy 31: 352–358

    Article  CAS  PubMed  Google Scholar 

  31. Hofmann C, Kiesslich R, Brackertz A, Jung M (1999) Propofol for sedation in gastroscopy–a randomized comparison with midazolam. Z Gastroenterol 37: 589–595

    CAS  PubMed  Google Scholar 

  32. Koshy G, Nair S, Norkus EP et al (2000) Propofol versus midazolam and meperidine for conscious sedation in GI endoscopy. Am J Gastroenterol 95: 1476–1479

    Article  CAS  PubMed  Google Scholar 

  33. Reimann FM, Samson U, Derad I et al (2000) Synergistic sedation with low-dose midazolam and propofol for colonoscopies. Endoscopy 32: 239–244

    Article  CAS  PubMed  Google Scholar 

  34. Horiuchi A, Nakayama Y, Katsuyama Y (2008) Safety and driving ability following low-dose propofol sedation. Digestion 78: 190–194

    Article  CAS  PubMed  Google Scholar 

  35. Roseveare C, Seavell C, Patel P et al (1998) Patient-controlled sedation and analgesia, using propofol and alfentanil, during colonoscopy: a prospective randomized controlled trial. Endoscopy 30: 768–773

    Article  CAS  PubMed  Google Scholar 

  36. Ulmer BJ, Hansen JJ, Overley CA et al (2003) Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists. Clin Gastroenterol Hepatol 1: 425–432

    Article  CAS  PubMed  Google Scholar 

  37. Wehrmann T, Grotkamp J, Stergiou N et al (2002) Electroencephalogram monitoring facilitates sedation with propofol for routine ERCP: a randomized, controlled trial. Gastrointest Endosc 56: 817–824

    Article  PubMed  Google Scholar 

  38. Wehrmann T, Riphaus A (2007) Sedation with propofol for interventional endoscopic procedures: A risk factor analysis. Scand J Gastroenterol 10: 1–7

    Google Scholar 

  39. Riphaus A, Stergiou N, Wehrmann T (2005) Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study. Am J Gastroenterol 100: 1957–1963

    Article  CAS  PubMed  Google Scholar 

  40. Scholer SG, Schafer DF, Potter JF (1990) The effect of age on the relative potency of midazolam and diazepam for sedation in upper gastrointestinal endoscopy. J Clin Gastroenterol 12: 145–147

    Article  CAS  PubMed  Google Scholar 

  41. A Plevris JN, Lo NT, Finlayson ND et al (1992) Age, anemia, and obesity-associated oxygen desaturation during upper gastrointestinal endoscopy. Gastrointest Endosc 38: 684–688

    Article  Google Scholar 

  42. Qureshi WA, Zuckerman MJ, Adler DG et al (2006) ASGE guideline: modifications in endoscopic practice for the elderly. Gastrointest Endosc 63: 566–569

    Article  PubMed  Google Scholar 

  43. Darling E (1997) Practical considerations in sedating the elderly. Crit Care Nurs Clin North Am 9: 371–380

    CAS  PubMed  Google Scholar 

  44. Heuss LT, Schnieper P, Drewe J et al (2003) Safety of propofol for conscious sedation during endoscopic procedures in high-risk patients-a prospective, controlled study. Am J Gastroenterol 98: 1751–1757

    CAS  PubMed  Google Scholar 

  45. Assy N, Rosser BG, Grahame GR, Minuk GY (1999) Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis. Gastrointest Endosc 49: 690–694

    Article  CAS  PubMed  Google Scholar 

  46. Vasudevan AE, Goh KL, Bulgiba AM (2002) Impairment of psychomotor responses after conscious sedation in cirrhotic patients undergoing therapeutic upper GI endoscopy. Am J Gastroenterol 97: 1717–1721

    Article  CAS  PubMed  Google Scholar 

  47. Hamdy NA, Kennedy HJ, Nicholl J, Triger DR (1986) Sedation for gastroscopy: a comparative study of midazolam and Diazemuls in patients with and without cirrhosis. Br J Clin Pharmacol 22: 643–647

    CAS  PubMed  Google Scholar 

  48. Riphaus A, Lechowicz I, Frenz MB, Wehrmann T (2009) Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: A randomized, controlled study. Scand J Gastroenterol 44: 1244–1251

    Article  CAS  PubMed  Google Scholar 

  49. Liebermann DA, Wuerker CK, Katon RM (1985) Cardiopulmonary risk of esopagogastroduodenoscopy. Role of endoscope diameter and systemic sedation. Gastroenterology 88: 468–472

    Google Scholar 

  50. Cooper MW, Davison CM, Uastin CA (1995) Arterial oxygen saturation during upper gastrointestinal endoscopy in elderly patients: the role of endoscope diameter. Age Ageing 24: 254–256

    Article  CAS  PubMed  Google Scholar 

  51. Rudin D, Kiss A, Wetz RV, Sottile VM (2007) Music in the endoscopy suite: a meta-analysis of randomized controlled studies. Endoscopy 39: 507–510

    Article  CAS  PubMed  Google Scholar 

  52. Seifert H, Schmitt TH, Gultekin T et al (2000) Sedation with propofol plus midazolam versus propofol alone for interventional endoscopic procedures: a prospective, randomized study. Aliment Pharmacol Ther 14: 1207–1214

    Article  CAS  PubMed  Google Scholar 

  53. Cordruwisch W, Doroschko M, Wurbs D (2000) Deep sedation in gastrointestinal endoscopic interventions: safety and reliability of a combination of midazolam and propofol. Dtsch Med Wochenschr 125: 619–622

    Article  CAS  PubMed  Google Scholar 

  54. VanNatta ME, Rex DK (2006) Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to moderate sedation for colonoscopy. Am J Gastroenterol 101: 2209–2217

    Article  CAS  PubMed  Google Scholar 

  55. Akcaboy ZN, Akcaboy EY, Albayrak D et al (2006) Can remifentanil be a better choice than propofol for colonoscopy during monitored anesthesia care? Acta Anaesthesiol Scand 50: 736–741

    Article  CAS  PubMed  Google Scholar 

  56. Moerman AT, Struys MM, Vereecke HE et al (2004) Remifentanil used to supplement propofol does not improve quality of sedation during spontaneous respiration. J Clin Anesth 16: 237–243

    Article  CAS  PubMed  Google Scholar 

  57. Sipe BW, Rex DK, Latinovich D (2002) Propofol versus midazolam/meperidine for outpatient colonoscopy: administration by nurses supervised by endoscopists. Gastrointest Endosc 55: 815–825. Erratum in: Gastrointest Endosc 56: 324

    Google Scholar 

  58. Heuss LT, Schnieper P, Drewe J et al (2003) Risk stratification and safe administration of propofol by registered nurses supervised by the gastroenterologist: a prospective observational study of more than 2000 cases. Gastrointest Endosc 57: 664–671

    Article  PubMed  Google Scholar 

  59. Ehlers APF, Bitter H (2006) Delegierung der Propofol-Applikation an Nicht-ärztliches Assistenzpersonal. Endo heute 19: 139–143

    Article  Google Scholar 

  60. Qadeer MA, Vargo JJ, Dumot JA et al (2009) Capnographic monitoring of respiratory activity improves safety of sedation for ERCP and EUS. Gastroenterology 136: 1568–1576

    Article  PubMed  Google Scholar 

  61. Paspatis GA, Chainaki I, Manolaraki M et al (2009) Efficacy of bispectral monitoring as an adjunct to propofol deep sedation for ERCP: a randomized controlled trial. Endoscopy (in press)

  62. Imagawa A, Fujiki S, Kawahara Y et al (2008) Satisfaction with bispectral index monitoring of propofol-mediated sedation during endoscopic submucosal dissection: a prospective, randomized study. Endoscopy 40: 905–909

    Article  CAS  PubMed  Google Scholar 

  63. Al-Sammak Z, Al-Falaki MM, Gamal HM (2005) Predictor of sedation during endoscopic retrograde cholangiopancreatography – bispectral index vs. clinical assessment. Middle East J Anaesthesiol 18: 141–148

    CAS  Google Scholar 

  64. Willey J, Vargo JJ, Connor JT et al (2002) Quantitative assessment of psychomotor recovery after sedation and analgesia for outpatient EGD. Gastrointest Endosc 56: 810–816

    Article  PubMed  Google Scholar 

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Interessenkonflikt

Die Autoren weisen auf folgende Beziehungen hin: Referentenhonorare von Fresenius Kabi, Falk Foundation, AstraZeneca. Unterstützung bei klinischen Studien: Fresenius Kabi, Oridion.

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Correspondence to A. Riphaus or T. Wehrmann.

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Riphaus, A., Wehrmann, T. Sedierung in der gastrointestinalen Endoskopie. Gastroenterologe 5, 143–155 (2010). https://doi.org/10.1007/s11377-009-0388-x

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