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Psychological stress and aging: role of glucocorticoids (GCs)

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Abstract

Psychological stress has extreme adverse consequences on health. However, the molecular mechanisms that mediate and accelerate the process of aging due to stress hormone are not well defined. This review has focused on diverse molecular paths that come out in response to chronic psychological stress via releasing of excessive glucocorticoids (GCs), involved in the aging process. GCs suppress transcription of nuclear cell adhesion molecules which impair synaptic plasticity, memory formation, and cognitive ability. Again, GCs promote muscle atrophy by means of motivating ubiquitin proteasome system and can repress muscle protein synthesis by inhibition of PI3-kinase/Akt pathway. GCs also inhibit interleukin-2 synthesis through suppressing T cell receptor signal that leads to loss of T cell activation, proliferation, and B-cell activation. Moreover, GCs increase the expression of collagenase-3, RANK ligand, and colony stimulating factor-1 that induce bone resorption. In general, stress-induced GCs can play causal role for aging and age-related disorders.

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Acknowledgements

The authors thank Dr. M. P. Mattson, National Institute of Ageing, Baltimore, MD, USA and Dr. Karl Riabowol, Dept. of Biochemistry and Molecular Biology and Oncology, Calgary University, Canada for critical reading and comments. The authors also like to acknowledge those of KUBIOTECH/MagBiotech group who supplied us hundreds of article on aging, GCs and psychological stress.

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  1. Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, 9208, Bangladesh

    K. M. Mehedi Hasan, Md. Shaifur Rahman, K. M. T. Arif & Mahbub E. Sobhani

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  1. K. M. Mehedi Hasan
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Correspondence to Md. Shaifur Rahman.

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Hasan, K.M.M., Rahman, M.S., Arif, K.M.T. et al. Psychological stress and aging: role of glucocorticoids (GCs). AGE 34, 1421–1433 (2012). https://doi.org/10.1007/s11357-011-9319-0

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