Abstract
Biomonitoring methods can be used to measure exposure to antibiotics in the general population; however, epidemiological data on the associations between urinary antibiotic levels and the cardiac profiles of enzymes lactate dehydrogenase, creatine kinase, and creatine kinase isoenzyme in older adults remain sparse. We investigated these associations in 990 individuals from the Cohort of Elderly Health and Environment Controllable Factors. Antibiotic residues in urine samples were analyzed using high-performance liquid chromatography–tandem mass spectrometry. Urinary levels of 34 antibiotics were measured. The participants’ cardiac enzyme profiles were influenced by sex, age, marital status, education level, cohabitation status, physical activity, dietary structure, body mass index, depression presence and salt, sugar, and oil consumption (P < 0.05). Oxytetracycline, tetracycline, doxycycline, sulfaclozine, and, florfenicol concentrations were negatively associated with the risk of having an abnormal cardiac enzyme profile. Older adults exposed to higher concentrations of norfloxacin had a higher risk of LDH anomalies. After antibiotics were classified, we identified associations between exposure to chloramphenicols, sulfonamides, or veterinary antibiotics and a lower risk of having an abnormal cardiac enzyme profile. Obtaining an accurate epidemiological profile of antibiotic exposure is indispensable for the prevention and detection of cardiac enzyme profile abnormalities in older adults.
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The datasets generated and analyzed during the current study are not publicly available due to the privacy of our research group, but are available from the corresponding author on reasonable request.
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Acknowledgements
We thank all the staff and students who made contributions to the cohort study. We thank all the study participants for their support. We are deeply grateful for the help provided by all the members in the experimental center platform for physical and chemical of Anhui Medical University.
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This work was supported by the National Natural Science Foundation of China (82073558), Research Fund for Scientific Research Level Improvement Plan of Anhui Medical University (2022xkjT007), and the Key Projects of Natural Science Research in Colleges and Universities of Anhui province (KJ2021A0268).
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Huimin Zheng contributed to formal analysis, data curation, and writing. Yachao Ni contributed to the investigation, data curation, and methodology. Sheng Wang contributed to the investigation, data curation, and resources. Menglong Geng contributed to the investigation, data curation, and resources. Hongjuan Cao contributed to the investigation, data curation, and resources. Wei Song contributed to the investigation, data curation, and resources. Kaiyong Liu contributed to the investigation, conceptualization, methodology, and supervision. Fangbiao Tao contributed to validation, conceptualization, and supervision.
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Zheng, H., Ni, Y., Wang, S. et al. Associations between antibiotic exposure and abnormal cardiac enzyme profiles in older Chinese adults. Environ Sci Pollut Res 30, 123679–123693 (2023). https://doi.org/10.1007/s11356-023-31082-7
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DOI: https://doi.org/10.1007/s11356-023-31082-7