Skip to main content

Advertisement

SpringerLink
Log in

Association of urinary bisphenols with thyroid function in the general population: a cross-sectional study of an industrial park in China

  • Research Article
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

Abstract

Bisphenols (BPs) are potential thyroid disruptors that are widely used in many consumer products, leading to their widespread exposure in the general population. Current cross-sectional and case-control studies have found associations between exposure to BPs and serum thyroid function, but the results were contradictory. The objectives of this study are to describe demographic characteristics, BP exposure levels, and thyroid function measurements in potentially exposed and control districts and to investigate the association of urinary BPs with thyroid function. Data were collected from a general population aged 3–79 years (N = 281) recruited by the Zhejiang Human Biomonitoring Program (ZJHBP). The concentrations of 10 kinds of BPs in urine and serum free triiodothyronine (FT3), total triiodothyronine (TT3), free thyroxine (FT4), total thyroxine (TT4), thyroid-stimulating hormone (TSH), thyroglobulin (Tg), thyroglobulin antibodies (TgAb), thyroid peroxidase antibodies (TPOAb), and thyrotropin receptor antibody (TRAb) in serum were measured. Multiple linear regression and weighted quantile sum (WQS) regression were used to estimate the relationship between single and mixed exposure of BPs and thyroid function. Bisphenol A (BPA), bisphenol S (BPS), and bisphenol P (BPP) were detected, respectively, in 82.73%, 94.24%, and 55.40% of the population in the exposed area and 81.69%, 61.27%, and 43.66% of the population in the control area. Among adult females, serum TT3 was negatively associated with urinary BPA (β = −0.033, 95% CI = −0.071, −0.008, P = 0.021). Among minor females, FT4 and Tg levels were negatively associated with the urinary BPA (β = −0.026, 95% CI = −0.051, −0.002, P = 0.032 for FT4; β = −0.129, 95% CI = −0.248, −0.009, P = 0.035 for Tg), and TPOAb was positively associated with urinary BPA (β = 0.104, 95% CI = 0.006, 0.203, P = 0.039). In WQS models, BPs mixture was positively associated with FT3 (βWQS = 0.022, 95% CI = 0.002, 0.042) and TT3 (βWQS = 0.033, 95% CI = 0.004, 0.062), and negatively associated with FT4 (βWQS = −0.024, 95% CI = −0.044, 0.004). We found widespread exposure to BPA, BPS, and BPP in the general population of Zhejiang province and found an association between BPA and thyroid hormones. This association is gender- and age-dependent and needs to be confirmed in further studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  • Aekplakorn W, Chailurkit LO, Ongphiphadhanakul B (2015) Relationship of serum bisphenol A with diabetes in the Thai population, National Health Examination Survey IV, 2009. J Diabetes 7:240–249

    Article  CAS  Google Scholar 

  • Ahn YA, Baek H, Choi M, Park J, Son SJ, Seo HJ, Jung J, Seong JK, Lee J, Kim S (2020) Adipogenic effects of prenatal exposure to bisphenol S (BPS) in adult F1 male mice. Sci Total Environ 728:138759

    Article  CAS  Google Scholar 

  • Aker AM, Ferguson KK, Rosario ZY, Mukherjee B, Alshawabkeh AN, Calafat AM, Cordero JF, Meeker JD (2019) A repeated measures study of phenol, paraben and triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort. Environ Health 18:28

    Article  Google Scholar 

  • Andrianou XD, Gangler S, Piciu A, Charisiadis P, Zira C, Aristidou K, Piciu D, Hauser R, Makris KC (2016) Human exposures to bisphenol A, bisphenol F and chlorinated bisphenol A derivatives and thyroid function. PLoS One 11:e0155237

    Article  Google Scholar 

  • Babelova A, Burckhardt BC, Salinas-Riester G, Pommerenke C, Burckhardt G, Henjakovic M (2015) Next generation sequencing of sex-specific genes in the livers of obese ZSF1 rats. Genomics 106:204–213

    Article  CAS  Google Scholar 

  • Blanco AM (2020) Hypothalamic- and pituitary-derived growth and reproductive hormones and the control of energy balance in fish. Gen Comp Endocrinol 287:113322

    Article  CAS  Google Scholar 

  • Brucker-Davis F, Ferrari P, Boda-Buccino M, Wagner-Mahler K, Pacini P, Gal J, Azuar P, Fenichel P (2011) Cord blood thyroid tests in boys born with and without cryptorchidism: correlations with birth parameters and in utero xenobiotics exposure. Thyroid 21:1133–1141

    Article  CAS  Google Scholar 

  • Bushnik T, Haines D, Levallois P, Levesque J, Van Oostdam J, Viau C (2010) Lead and bisphenol A concentrations in the Canadian population. Health Rep 21:7–18

    Google Scholar 

  • Carrico C, Gennings C, Wheeler DC, Factor-Litvak P (2015) Characterization of weighted quantile sum regression for highly correlated data in a risk analysis setting. J Agric Biol Environ Stat 20:100–120

    Article  Google Scholar 

  • Casas M, Forns J, Martinez D, Avella-Garcia C, Valvi D, Ballesteros-Gomez A, Luque N, Rubio S, Julvez J, Sunyer J, Vrijheid M (2015) Exposure to bisphenol A during pregnancy and child neuropsychological development in the INMA-Sabadell cohort. Environ Res 142:671–679

    Article  CAS  Google Scholar 

  • Chailurkit LO, Aekplakorn W, Ongphiphadhanakul B (2016) The association of serum bisphenol A with thyroid autoimmunity. Int J Environ Res Public Health 13

  • Chakraborty P, Sampath S, Mukhopadhyay M, Selvaraj S, Bharat GK, Nizzetto L (2019) Baseline investigation on plasticizers, bisphenol A, polycyclic aromatic hydrocarbons and heavy metals in the surface soil of the informal electronic waste recycling workshops and nearby open dumpsites in Indian metropolitan cities. Environ Pollut 248:1036–1045

    Article  CAS  Google Scholar 

  • Covaci A, Den Hond E, Geens T, Govarts E, Koppen G, Frederiksen H, Knudsen LE, Morck TA, Gutleb AC, Guignard C, Cocco E, Horvat M, Heath E, Kosjek T, Mazej D, Tratnik JS, Castano A, Esteban M, Cutanda F et al (2015) Urinary BPA measurements in children and mothers from six European member states: overall results and determinants of exposure. Environ Res 141:77–85

    Article  CAS  Google Scholar 

  • Cui FP, Yang P, Liu C, Chen PP, Deng YL, Miao Y, Luo Q, Zhang M, Lu WQ, Zeng Q (2021) Urinary bisphenol A and its alternatives among pregnant women: predictors and risk assessment. Sci Total Environ 784:147184

    Article  CAS  Google Scholar 

  • De Filippis E, Li T, Rosen ED (2018) Exposure of adipocytes to bisphenol-A in vitro interferes with insulin action without enhancing adipogenesis. PLoS One 13:e0201122

    Article  Google Scholar 

  • Derakhshan A, Philips EM, Ghassabian A, Santos S, Asimakopoulos AG, Kannan K, Kortenkamp A, Jaddoe VWV, Trasande L, Peeters RP, Korevaar TIM (2021) Association of urinary bisphenols during pregnancy with maternal, cord blood and childhood thyroid function. Environ Int 146:106160

    Article  CAS  Google Scholar 

  • Derakhshan A, Shu H, Peeters RP, Kortenkamp A, Lindh CH, Demeneix B, Bornehag CG, Korevaar TIM (2019) Association of urinary bisphenols and triclosan with thyroid function during early pregnancy. Environ Int 133:105123

    Article  CAS  Google Scholar 

  • EPA, US (2011) Exposure factors handbook: 2011 edition.E P A / 6 0 0 / R-09/052F. National Center for Environmental Assessment, Washington, DC

    Google Scholar 

  • Farrugia F, Aquilina A, Vassallo J, Pace NP (2021) Bisphenol A and type 2 diabetes mellitus: a review of epidemiologic, functional, and early life factors. Int J Environ Res Public Health 18

  • Fernandez MO, Bourguignon NS, Arocena P, Rosa M, Libertun C, Lux-Lantos V (2018) Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats. Toxicol Lett 285:81–86

    Article  CAS  Google Scholar 

  • Frederiksen H, Aksglaede L, Sorensen K, Nielsen O, Main KM, Skakkebaek NE, Juul A, Andersson AM (2013a) Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC-MS/MS. Int J Hyg Environ Health 216:710–720

    Article  CAS  Google Scholar 

  • Frederiksen H, Nielsen JK, Morck TA, Hansen PW, Jensen JF, Nielsen O, Andersson AM, Knudsen LE (2013b) Urinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother-child pairs. Int J Hyg Environ Health 216:772–783

    Article  CAS  Google Scholar 

  • Gentilcore D, Porreca I, Rizzo F, Ganbaatar E, Carchia E, Mallardo M, De Felice M, Ambrosino C (2013) Bisphenol A interferes with thyroid specific gene expression. Toxicology 304:21–31

    Article  CAS  Google Scholar 

  • Guo C, Ren F, Jin J, Zhang H, Wang L, Zhang H, Chen J (2021) Internal exposure of Chinese children from a typical coastal city to bisphenols and possible association with thyroid hormone levels. Environ Int 156:106759

    Article  CAS  Google Scholar 

  • Guo J, Wu C, Zhang J, Li W, Lv S, Lu D, Qi X, Feng C, Liang W, Chang X, Zhang Y, Xu H, Cao Y, Wang G, Zhou Z (2020) Maternal and childhood urinary phenol concentrations, neonatal thyroid function, and behavioral problems at 10 years of age: The SMBCS study. Sci Total Environ 743:140678

    Article  CAS  Google Scholar 

  • Gys C, Ait Bamai Y, Araki A, Bastiaensen M, Caballero-Casero N, Kishi R, Covaci A (2020) Biomonitoring and temporal trends of bisphenols exposure in Japanese school children. Environ Res 191:110172

    Article  CAS  Google Scholar 

  • Hatch EE, Nelson JW, Stahlhut RW, Webster TF (2010) Association of endocrine disruptors and obesity: perspectives from epidemiological studies. Int J Androl 33:324–332

    Article  CAS  Google Scholar 

  • He Y, Miao M, Herrinton LJ, Wu C, Yuan W, Zhou Z, Li DK (2009) Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levels. Environ Res 109:629–633

    Article  CAS  Google Scholar 

  • Heffernan AL, Thompson K, Eaglesham G, Vijayasarathy S, Mueller JF, Sly PD, Gomez MJ (2016) Rapid, automated online SPE-LC-QTRAP-MS/MS method for the simultaneous analysis of 14 phthalate metabolites and 5 bisphenol analogues in human urine. Talanta 151:224–233

    Article  CAS  Google Scholar 

  • Jang Y, Choi YJ, Lim YH, Lee KS, Kim BN, Shin CH, Lee YA, Kim JI, Hong YC (2021) Associations between thyroid hormone levels and urinary concentrations of bisphenol A, F, and S in 6-year-old children in Korea. J Prev Med Public Health 54:37–45

    Article  Google Scholar 

  • Jiang Y, Li J, Xu S, Zhou Y, Zhao H, Li Y, Xiong C, Sun X, Liu H, Liu W, Peng Y, Hu C, Cai Z, Xia W (2020) Prenatal exposure to bisphenol A and its alternatives and child neurodevelopment at 2 years. J Hazard Mater 388:121774

    Article  CAS  Google Scholar 

  • John N, Rehman H, Razak S, David M, Ullah W, Afsar T, Almajwal A, Alam I, Jahan S (2019) Comparative study of environmental pollutants bisphenol A and bisphenol S on sexual differentiation of anteroventral periventricular nucleus and spermatogenesis. Reprod Biol Endocrinol 17:53

    Article  Google Scholar 

  • Kang S, Shin BH, Kwon JA, Lee CW, Park EK, Park EY, Kim B (2020) Urinary bisphenol A and its analogues and haemato-biochemical alterations of pregnant women in Korea. Environ Res 182:109104

    Article  CAS  Google Scholar 

  • Kataria A, Levine D, Wertenteil S, Vento S, Xue J, Rajendiran K, Kannan K, Thurman JM, Morrison D, Brody R, Urbina E, Attina T, Trasande L, Trachtman H (2017) Exposure to bisphenols and phthalates and association with oxidant stress, insulin resistance, and endothelial dysfunction in children. Pediatr Res 81:857–864

    Article  CAS  Google Scholar 

  • Kjaergaard AD, Marouli E, Papadopoulou A, Deloukas P, Kus A, Sterenborg R, Teumer A, Burgess S, Asvold BO, Chasman DI, Medici M, Ellervik C (2021) Thyroid function, sex hormones and sexual function: a Mendelian randomization study. Eur J Epidemiol 36:335–344

    Article  CAS  Google Scholar 

  • Larsson K, Lindh CH, Jonsson BA, Giovanoulis G, Bibi M, Bottai M, Bergstrom A, Berglund M (2017) Phthalates, non-phthalate plasticizers and bisphenols in Swedish preschool dust in relation to children's exposure. Environ Int 102:114–124

    Article  CAS  Google Scholar 

  • Larsson K, Ljung Bjorklund K, Palm B, Wennberg M, Kaj L, Lindh CH, Jonsson BA, Berglund M (2014) Exposure determinants of phthalates, parabens, bisphenol A and triclosan in Swedish mothers and their children. Environ Int 73:323–333

    Article  CAS  Google Scholar 

  • Lee I, Park JY, Kim S, An JN, Lee J, Park H, Jung SK, Kim SY, Lee JP, Choi K (2020) Association of exposure to phthalates and environmental phenolics with markers of kidney function: Korean National Environmental Health Survey (KoNEHS) 2015-2017. Environ Int 143:105877

    Article  CAS  Google Scholar 

  • Lee J, Choi K, Park J, Moon HB, Choi G, Lee JJ, Suh E, Kim HJ, Eun SH, Kim GH, Cho GJ, Kim SK, Kim S, Kim SY, Kim S, Eom S, Choi S, Kim YD, Kim S (2018) Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother-neonate pairs. Sci Total Environ 626:1494–1501

    Article  CAS  Google Scholar 

  • Li L, Ying Y, Zhang C, Wang W, Li Y, Feng Y, Liang J, Song H, Wang Y (2019) Bisphenol A exposure and risk of thyroid nodules in Chinese women: a case-control study. Environ Int 126:321–328

    Article  CAS  Google Scholar 

  • Liang J, Liu S, Liu T, Yang C, Wu Y, Jennifer Tan HJ, Wei B, Ma X, Feng B, Jiang Q, Huang D, Qiu X (2020) Association of prenatal exposure to bisphenols and birth size in Zhuang ethnic newborns. Chemosphere 252:126422

    Article  CAS  Google Scholar 

  • Liu M, Jia S, Dong T, Han Y, Xue J, Wanjaya ER, Fang M (2019a) The occurrence of bisphenol plasticizers in paired dust and urine samples and its association with oxidative stress. Chemosphere 216:472–478

    Article  CAS  Google Scholar 

  • Liu Y, Yan Z, Zhang Q, Song N, Cheng J, Torres OL, Chen J, Zhang S, Guo R (2019b) Urinary levels, composition profile and cumulative risk of bisphenols in preschool-aged children from Nanjing suburb, China. Ecotoxicol Environ Saf 172:444–450

    Article  CAS  Google Scholar 

  • Machtinger R, Berman T, Adir M, Mansur A, Baccarelli AA, Racowsky C, Calafat AM, Hauser R, Nahum R (2018) Urinary concentrations of phthalate metabolites, bisphenols and personal care product chemical biomarkers in pregnant women in Israel. Environ Int 116:319–325

    Article  CAS  Google Scholar 

  • Mahalingaiah S, Meeker JD, Pearson KR, Calafat AM, Ye X, Petrozza J, Hauser R (2008) Temporal variability and predictors of urinary bisphenol A concentrations in men and women. Environ Health Perspect 116:173–178

    Article  CAS  Google Scholar 

  • Meeker JD, Ferguson KK (2011) Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008. Environ Health Perspect 119:1396–1402

    Article  CAS  Google Scholar 

  • Mendy A, Salo PM, Wilkerson J, Feinstein L, Ferguson KK, Fessler MB, Thorne PS, Zeldin DC (2020) Association of urinary levels of bisphenols F and S used as bisphenol A substitutes with asthma and hay fever outcomes. Environ Res 183:108944

    Article  CAS  Google Scholar 

  • Mhaouty-Kodja S, Belzunces LP, Canivenc MC, Schroeder H, Chevrier C, Pasquier E (2018) Impairment of learning and memory performances induced by BPA: evidences from the literature of a MoA mediated through an ED. Mol Cell Endocrinol 475:54–73

    Article  CAS  Google Scholar 

  • Milczarek-Banach J, Rachon D, Bednarczuk T, Mysliwiec-Czajka K, Wasik A, Miskiewicz P (2020) Exposure to bisphenol A analogs and the thyroid function and volume in women of reproductive age-cross-sectional study. Front Endocrinol (Lausanne) 11:587252

    Article  Google Scholar 

  • Moriyama K, Tagami T, Akamizu T, Usui T, Saijo M, Kanamoto N, Hataya Y, Shimatsu A, Kuzuya H, Nakao K (2002) Thyroid hormone action is disrupted by bisphenol A as an antagonist. J Clin Endocrinol Metab 87:5185–5190

    Article  CAS  Google Scholar 

  • Mustieles V, D'Cruz SC, Couderq S, Rodriguez-Carrillo A, Fini JB, Hofer T, Steffensen IL, Dirven H, Barouki R, Olea N, Fernandez MF, David A (2020) Bisphenol A and its analogues: a comprehensive review to identify and prioritize effect biomarkers for human biomonitoring. Environ Int 144:105811

    Article  CAS  Google Scholar 

  • Myridakis A, Fthenou E, Balaska E, Vakinti M, Kogevinas M, Stephanou EG (2015) Phthalate esters, parabens and bisphenol-A exposure among mothers and their children in Greece (Rhea cohort). Environ Int 83:1–10

    Article  CAS  Google Scholar 

  • Nguyen HD (2023) An evaluation of the effects of mixed heavy metals on prediabetes and type 2 diabetes: epidemiological and toxicogenomic analysis. Environ Sci Pollut Res Int 30:82437–82457

    Article  CAS  Google Scholar 

  • Nguyen HD, Kim MS (2022) Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases. Environ Pollut 309:119780

    Article  CAS  Google Scholar 

  • Olsen L, Lampa E, Birkholz DA, Lind L, Lind PM (2012) Circulating levels of bisphenol A (BPA) and phthalates in an elderly population in Sweden, based on the prospective investigation of the vasculature in Uppsala Seniors (PIVUS). Ecotoxicol Environ Saf 75:242–248

    Article  CAS  Google Scholar 

  • Ouyang F, Zhang GH, Du K, Shen L, Ma R, Wang X, Wang X, Zhang J (2020) Maternal prenatal urinary bisphenol A level and child cardio-metabolic risk factors: a prospective cohort study. Environ Pollut 265:115008

    Article  CAS  Google Scholar 

  • Pagnin M, Kondos-Devcic D, Chincarini G, Cumberland A, Richardson SJ, Tolcos M (2021) Role of thyroid hormones in normal and abnormal central nervous system myelination in humans and rodents. Front Neuroendocrinol 61:100901

    Article  CAS  Google Scholar 

  • Park C, Choi W, Hwang M, Lee Y, Kim S, Yu S, Lee I, Paek D, Choi K (2017) Associations between urinary phthalate metabolites and bisphenol A levels, and serum thyroid hormones among the Korean adult population - Korean National Environmental Health Survey (KoNEHS) 2012-2014. Sci Total Environ 584-585:950–957

    Article  CAS  Google Scholar 

  • Peinado FM, Lendinez I, Sotelo R, Iribarne-Duran LM, Fernandez-Parra J, Vela-Soria F, Olea N, Fernandez MF, Freire C, Leon J, Perez-Cabrera B, Ocon-Hernandez O, Artacho-Cordon F (2020) Association of urinary levels of bisphenols A, F, and S with endometriosis risk: preliminary results of the EndEA study. Int J Environ Res Public Health 17(4):1194.

  • Philips EM, Jaddoe VWV, Asimakopoulos AG, Kannan K, Steegers EAP, Santos S, Trasande L (2018) Bisphenol and phthalate concentrations and its determinants among pregnant women in a population-based cohort in the Netherlands, 2004-5. Environ Res 161:562–572

    Article  CAS  Google Scholar 

  • Pollack AZ, Perkins NJ, Sjaarda L, Mumford SL, Kannan K, Philippat C, Wactawski-Wende J, Schisterman EF (2016) Variability and exposure classification of urinary phenol and paraben metabolite concentrations in reproductive-aged women. Environ Res 151:513–520

    Article  CAS  Google Scholar 

  • Quiros-Alcala L, Hansel NN, McCormack M, Calafat AM, Ye X, Peng RD, Matsui EC (2021) Exposure to bisphenols and asthma morbidity among low-income urban children with asthma. J Allergy Clin Immunol 147:577–586.e577

    Article  CAS  Google Scholar 

  • Radwan M, Wielgomas B, Dziewirska E, Radwan P, Kaluzny P, Klimowska A, Hanke W, Jurewicz J (2018) Urinary bisphenol A levels and male fertility. Am J Mens Health 12:2144–2151

    Article  Google Scholar 

  • Rezg R, Abot A, Mornagui B, Aydi S, Knauf C (2018) Effects of bisphenol S on hypothalamic neuropeptides regulating feeding behavior and apelin/APJ system in mice. Ecotoxicol Environ Saf 161:459–466

    Article  CAS  Google Scholar 

  • Sarzo B, Abumallouh R, Marin N, Llop S, Beneito A, Lopez-Flores I, Ferrero N, Sakhi AK, Ballester F, Lopez-Espinosa MJ (2022) Association between phenols and thyroid hormones: the role of iodothyronine deiodinase genes. Environ Pollut 311:119926

    Article  CAS  Google Scholar 

  • Schirmer E, Schuster S, Machnik P (2021) Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains. Commun Biol 4:465

    Article  CAS  Google Scholar 

  • Silva JF, Ocarino NM, Serakides R (2018) Thyroid hormones and female reproduction. Biol Reprod 99:907–921

    Google Scholar 

  • Sinha RA, Singh BK, Yen PM (2018) Direct effects of thyroid hormones on hepatic lipid metabolism. Nat Rev Endocrinol 14:259–269

    Article  CAS  Google Scholar 

  • Sowlat MH, Lotfi S, Yunesian M, Ahmadkhaniha R, Rastkari N (2016) The association between bisphenol A exposure and type-2 diabetes: a world systematic review. Environ Sci Pollut Res Int 23:21125–21140

    Article  CAS  Google Scholar 

  • Sriphrapradang C, Chailurkit LO, Aekplakorn W, Ongphiphadhanakul B (2013) Association between bisphenol A and abnormal free thyroxine level in men. Endocrine 44:441–447

    Article  CAS  Google Scholar 

  • Sur U, Erkekoglu P, Bulus AD, Andiran N, Kocer-Gumusel B (2019) Oxidative stress markers, trace elements, and endocrine disrupting chemicals in children with Hashimoto’s thyroiditis. Toxicol Mech Methods 29:633–643

    Article  CAS  Google Scholar 

  • Suzuki S, Nishio S, Takeda T, Komatsu M (2012) Gender-specific regulation of response to thyroid hormone in aging. Thyroid Res 5:1

    Article  CAS  Google Scholar 

  • Tai X, Chen Y (2016) Urinary bisphenol A concentrations positively associated with glycated hemoglobin and other indicators of diabetes in Canadian men. Environ Res 147:172–178

    Article  CAS  Google Scholar 

  • Tkalec Z, Kosjek T, Snoj Tratnik J, Stajnko A, Runkel AA, Sykiotou M, Mazej D, Horvat M (2021) Exposure of Slovenian children and adolescents to bisphenols, parabens and triclosan: urinary levels, exposure patterns, determinants of exposure and susceptibility. Environ Int 146:106172

    Article  CAS  Google Scholar 

  • van der Meer TP, van Faassen M, Frederiksen H, van Beek AP, Wolffenbuttel BHR, Kema IP, van Vliet-Ostaptchouk JV (2019) Development and interlaboratory validation of two fast UPLC-MS-MS methods determining urinary bisphenols, parabens and phthalates. J Anal Toxicol 43:452–464

    Article  Google Scholar 

  • Vassalle C, Parlanti A, Pingitore A, Berti S, Iervasi G, Sabatino L (2021) Vitamin D, thyroid hormones and cardiovascular risk: exploring the components of this novel disease triangle. Front Physiol 12:722912

    Article  Google Scholar 

  • Vuong AM, Braun JM, Webster GM, Thomas Zoeller R, Hoofnagle AN, Sjodin A, Yolton K, Lanphear BP, Chen A (2018) Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3years. Environ Int 117:339–347

    Article  CAS  Google Scholar 

  • Wang B, Li M, Zhao Z, Lu J, Chen Y, Xu Y, Xu M, Wang W, Wang T, Bi Y, Ning G (2019) Urinary bisphenol A concentration and glucose homeostasis in non-diabetic adults: a repeated-measures, longitudinal study. Diabetologia 62:1591–1600

    Article  CAS  Google Scholar 

  • Wang F, Hua J, Chen M, Xia Y, Zhang Q, Zhao R, Zhou W, Zhang Z, Wang B (2012) High urinary bisphenol A concentrations in workers and possible laboratory abnormalities. Occup Environ Med 69:679–684

    Article  CAS  Google Scholar 

  • Wang X, Tang N, Nakayama SF, Fan P, Liu Z, Zhang J, Ouyang F (2020) Maternal urinary bisphenol A concentration and thyroid hormone levels of Chinese mothers and newborns by maternal body mass index. Environ Sci Pollut Res Int 27:10939–10949

    Article  CAS  Google Scholar 

  • Wormsbaecher C, Hindman AR, Avendano A, Cortes-Medina M, Jones CE, Bushman A, Onua L, Kovalchin CE, Murphy AR, Helber HL, Shapiro A, Voytovitch K, Kuang X, Aguilar-Valenzuela R, Leight JL, Song JW, Burd CJ (2020) In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness. Breast Cancer Res 22:41

    Article  CAS  Google Scholar 

  • Wu Y, Beland FA, Fang JL (2016) Effect of triclosan, triclocarban, 2,2',4,4'-tetrabromodiphenyl ether, and bisphenol A on the iodide uptake, thyroid peroxidase activity, and expression of genes involved in thyroid hormone synthesis. Toxicol In Vitro 32:310–319

    Article  CAS  Google Scholar 

  • wuHu J, Zhao H, Braun JM, Zheng T, Zhang B, Xia W, Zhang W, Li J, Zhou Y, Li H, Li J, Zhou A, Zhang Y, Buka SL, Liu S, Peng Y, Wu C, Jiang M, Huo W et al (2019) Associations of trimester-specific exposure to bisphenols with size at birth: a Chinese prenatal cohort study. Environ Health Perspect 127:107001

    Article  Google Scholar 

  • Yamazaki E, Yamashita N, Taniyasu S, Lam J, Lam PK, Moon HB, Jeong Y, Kannan P, Achyuthan H, Munuswamy N, Kannan K (2015) Bisphenol A and other bisphenol analogues including BPS and BPF in surface water samples from Japan, China, Korea and India. Ecotoxicol Environ Saf 122:565–572

    Article  CAS  Google Scholar 

  • Ye X, Pierik FH, Angerer J, Meltzer HM, Jaddoe VW, Tiemeier H, Hoppin JA, Longnecker MP (2009) Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa). Int J Hyg Environ Health 212:481–491

    Article  CAS  Google Scholar 

  • Zhang T, Xue J, Gao CZ, Qiu RL, Li YX, Li X, Huang MZ, Kannan K (2016) Urinary Concentrations of Bisphenols and their association with biomarkers of oxidative stress in people living near e-waste recycling facilities in China. Environ Sci Technol 50:4045–4053

    Article  CAS  Google Scholar 

  • Zhang Y, Ling Y, Zhang Y, Zhang F (2019) Research progress on pretreatment and detection of bisphenols in food and environmental samples. Se Pu 37:1268–1274

    CAS  Google Scholar 

Download references

Acknowledgements

We are thankful to all participants in the ZJHBP study.

Funding

This study was a part of the Zhejiang Human Biomonitoring Program (ZJHBP) of the Zhejiang Center for Disease Control and Prevention, Republic of China, which was supported by the Central Guiding Local Science and Technology Development Fund Projects (No. 2023ZY1024).

Author information

Author notes

  1. Yang Hu and Shiming Lai contributed equally to this work.

Authors and Affiliations

  1. Zhejiang Provincial Center for Disease Control and Prevention, 3399 Bin Sheng Road, Binjiang District, Hangzhou, 310051, China

    Yang Hu, Mingluan Xing, Xueqing Li, Dandan Xu, Yuan Chen, Jie Xiang, Ping Cheng, Xiaofeng Wang, Zhijian Chen, Peiwei Xu & Xiaoming Lou

  2. Quzhou Center for Disease Control and Prevention, 154 Xi’an Road, Ke Cheng District, Quzhou, 324000, China

    Shiming Lai

  3. Key Laboratory of Environmental Pollution Control Technology of Zhejiang Province, Hangzhou, 310007, China

    Ying Li, Xiaodong Wu & Hao Ding

  4. Environmental Science Research & Design Institute of Zhejiang Province, Zhejiang, 310007, Hangzhou, China

    Ying Li, Xiaodong Wu & Hao Ding

Authors
  1. Yang Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shiming Lai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ying Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xiaodong Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mingluan Xing
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xueqing Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Dandan Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yuan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Jie Xiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Ping Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Xiaofeng Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Zhijian Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Hao Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Peiwei Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Xiaoming Lou
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Yang Hu: conceptualization; data curation; formal analysis; investigation; writing—original draft.

Shiming Lai: methodology; formal analysis.

Ying Li: investigation.

Xiaodong Wu: investigation.

Mingluan Xing: formal analysis.

Xueqing Li: investigation.

Dandan Xu: investigation.

Yuan Chen: formal analysis.

Jie Xiang: formal analysis.

Ping Cheng: formal analysis.

Xiaofeng Wang: supervision; funding acquisition.

Zhijian Chen: methodology; conceptualization.

Hao Ding: investigation.

Peiwei Xu: investigation; writing—review and editing; supervision.

Xiaoming Lou: funding acquisition; supervision.

Corresponding author

Correspondence to Xiaoming Lou.

Ethics declarations

Ethical approval

The study was approved by the Human Ethics Committee of Zhejiang Provincial Center for Disease Control and Prevention.

Consent to participate

All authors and participants have agreed to participate in this study.

Competing interests

The authors declare no competing interests.

Additional information

Responsible Editor: Lotfi Aleya

The contents of this study have not been previously published and have not been submitted elsewhere.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

ESM 1

(DOCX 90 kb)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hu, Y., Lai, S., Li, Y. et al. Association of urinary bisphenols with thyroid function in the general population: a cross-sectional study of an industrial park in China. Environ Sci Pollut Res 30, 107517–107532 (2023). https://doi.org/10.1007/s11356-023-29932-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-023-29932-5

Keywords

Search

Navigation