Abstract
Heavy metals are toxic to human health and their concentrations in drinking water are sometimes above the limits recommended by the World Health Organization (WHO). In addition to drinking water, a possible source for the intake of heavy metals is nasal sprays, which are frequently used to combat upper respiratory tract infections, especially in young children. Different types of nasal sprays are sold in pharmacies, such as saline solutions prepared from NaCl, sea water, or ocean water. In this work, Al, Sb, As, B, Cd, Cr, Co, Cu, Fe, Mn, Ni, Si, and Zn analyzes were performed on 22 saline samples with ICP-MS to determine their toxicity levels. For some samples, the toxic element concentrations were above the drinking water limits. Because nasal sprays are administered to the region close to the brain, the potential risk should be considered more fully. The accuracy of the results was tested by the standard addition method and certified reference material (CRM) analysis, which obtained recovery values for the elements of 83%-115% and 82%-108% for standard addition and CRM analysis, respectively. This is the first study to consider the risk of heavy metals in nasal sprays.
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The datasets used and/or analyzed during the current study are available from the corresponding author (Tülin DENİZ ÇİFTÇİ) on reasonable request.
References
Abdi L, Jahed-Khaniki GR, Molaee-Aghaee E et al (2021) The preliminary survey on the concentration of potentially toxic elements (PTEs) in salt samples collected from Tehran, Iran: a probabilistic health risk assessment. Environ Sci Pollut Res 28:62651–62661. https://doi.org/10.1007/s11356-021-14720-w
Aydin-Onen S, Ozturk M (2017) Investigation of heavy metal pollution in eastern Aegean Sea coastal waters by using Cystoseira barbata, Patella caerulea, and Liza aurata as biological indicators. Environ Sci Pollut Res 24:7310–7334. https://doi.org/10.1007/s11356-016-8226-4
Batayneh AT (2012) Toxic (aluminum, beryllium, boron, chromium and zinc) in groundwater: health risk assessment. Int J Environ Sci Technol 9:153–162. https://doi.org/10.1007/s13762-011-0009-3
Boreiko CJ, Rossman TG (2020) Antimony and its compounds: Health impacts related to pulmonary toxicity, cancer, and genotoxicity. Toxicol Appl Pharmacol 403:115156. https://doi.org/10.1016/j.taap.2020.115156
Budavari S (1989) The Merck index, 11th edn. Merck and Co., Inc., Rahway, New Jersey
Chan MWH, Hasan KA, Balthazar-Silva D et al (2021) Evaluation of heavy metal pollutants in salt and seawater under the influence of the Lyari River and potential health risk assessment. Mar Pollut Bull 166:112215. https://doi.org/10.1016/j.marpolbul.2021.112215
Choong TSY, Chuah TG, Robiah Y et al (2007) Arsenic toxicity, health hazards and removal techniques from water: an overview. Desalination 217:139–166. https://doi.org/10.1016/j.desal.2007.01.015
Cotton FA, Wilkinson G (1988) Advanced inorganic chemistry, 5th edn. John Wiley & Sons, Ltd, New York, NY
Demey H, Barron-Zambrano J, Mhadhbi T et al (2019) Boron Removal from Aqueous Solutions by Using a Novel Alginate-Based Sorbent: Comparison with Al(2)O(3) Particles. Polymers (basel) 11:1509. https://doi.org/10.3390/polym11091509
Friis RH (2012) Essentials of environmental health, 2nd edn. Jones and Bartlett Learning, Canada
Gao Y, Qiao Y, Xu Y et al (2021) Assessment of the transfer of heavy metals in seawater, sediment, biota samples and determination the baseline tissue concentrations of metals in marine organisms. Environ Sci Pollut Res 28:28764–28776. https://doi.org/10.1007/s11356-021-12650-1
Gillette Guyonnet S, Andrieu S, Vellas B (2007) The potential influence of silica present in drinking water on Alzheimer’s disease and associated disorders. J Nutr Health Aging 11:119–124
Harasim P, Filipek T (2015) Nickel in the environment. J Elem 20:525–534. https://doi.org/10.5601/jelem.2014.19.3.651
Hilal N, Kim GJ, Somerfield C (2011) Boron removal from saline water: A comprehensive review. Desalination 273:23–35. https://doi.org/10.1016/j.desal.2010.05.012
International Agency for Research on Cancer (1993) Summaries and evaluations: cadmium and cadmium compounds (Group 1) Volume 58
Ismael M, Mokhtar A, Adil H et al (2022) Appraisal of heavy metals exposure risks via water pathway by using a combination pollution indices approaches, and the associated potential health hazards on population, Red Sea State, Sudan. Phys Chem Earth Parts A/B/C 127:103153. https://doi.org/10.1016/j.pce.2022.103153
Jaishankar M, Tseten T, Anbalagan N et al (2014) Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol 7:60–72. https://doi.org/10.2478/intox-2014-0009
Joint FAO/WHO Expert Committee on Food Additives (1983) Toxicological evaluation of certain food additives and food contaminants. Cambridge University Press, Cambridge, WHO Food A
Kuhlmann AM (1963) The second most abundant element in the earth’s crust. JOM 15:502–505. https://doi.org/10.1007/BF03378936
Lenntech (n.d.) Silicon and water: reaction mechanisms, environmental impact and health effects. https://www.lenntech.com/periodic/water/silicon/silicon-and-water.htm. Accessed 6 Jul 2023
Luo M, Zhang Y, Li H et al (2022) Pollution assessment and sources of dissolved heavy metals in coastal water of a highly urbanized coastal area: The role of groundwater discharge. Sci Total Environ 807:151070. https://doi.org/10.1016/j.scitotenv.2021.151070
Mandal B, Suzuki K (2002) Arsenic round the world: a review. Talanta 58:201–235
Montuori P, Aurino S, Garzonio F et al (2016) Estimation of heavy metal loads from Tiber River to the Tyrrhenian Sea and environmental quality assessment. Environ Sci Pollut Res 23:23694–23713. https://doi.org/10.1007/s11356-016-7557-5
Nassef E, Eltaweel Y (2019) Removal of zinc from aqueous solution using activated oil shale. J Chem 2019:4261210. https://doi.org/10.1155/2019/4261210
Nriagu J (1980) Zinc in the environment, part I, ecological cycling. Wiley, New York
Patil DS, Chavan SM, Oubagaranadin JUK (2016) A review of technologies for manganese removal from wastewaters. J Environ Chem Eng 4:468–487. https://doi.org/10.1016/j.jece.2015.11.028
Sundar S, Chakravarty J (2010) Antimony Toxicity. Public Heal, Int. J. Environ. Res, p 7
Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ (2012) Heavy metals toxicity and the environment. EXS 101:133–164. https://doi.org/10.1007/978-3-7643-8340-4_6
Turkish Standard Institution (2005) Water intended for human consumption TS-266. https://intweb.tse.org.tr/Standard/Standard/Standard.aspx?081118051115108051104119110104055047105102120088111043113104073100115103084043078075072076065089. Accessed 6 Jul 2023
United States Environmental Protection Agency (2004) Drinking water health advisory for Manganese. https://www.epa.gov/sites/default/files/2014-09/documents/support_cc1_magnese_dwreport_0.pdf. Accessed 6 July 2023
United States Environmental Protection Agency (2016) Cobalt compounds. https://www.epa.gov/sites/default/files/2016-09/documents/cobalt-compounds.pdf. Accessed 6 July 2023
World Health Organization (2003) Zinc in drinking-water. In: Backgr Doc Dev WHO Guidel Drink Qual https://cdn.who.int/media/docs/default-source/wash-documents/wash-chemicals/zinc.pdf?sfvrsn=9529d066_4. Accessed 6 Jul 2023
World Health Organization (2005) Nickel in Drinking water. In: WHO/SDE/WSH/05.08/55. https://cdn.who.int/media/docs/default-source/wash-documents/wash-chemicals/nickel-background-document.pdf?sfvrsn=90644b9f_9. Accessed 6 Jul 2023
World Health Organization (2006) Cobalt and inorganic cobalt compounds. https://apps.who.int/iris/handle/10665/43426. Accessed 6 Jul 2023
World Health Organization (2011a) Guidelines for drinking-water quality. https://apps.who.int/iris/bitstream/handle/10665/44584/9789241548151_eng.pdf. Accessed 6 Jul 2023
World Health Organization (2011b) Copper in Drinking-water background document for development of WHO Guidelines for drinking-water quality
World Health Organization (2017) Guidelines for drinking- water quality, 4th edn. https://www.who.int/publications/i/item/9789241549950. Accessed 6 Jul 2023
World Health Organization (2019) Exposure to cadmium: a major public health concern. https://www.who.int/publications/i/item/WHO-CED-PHE-EPE-19-4-3. Accessed 6 Jul 2023
World Health Organization (2021a) Lead poisoning. https://www.who.int/news-room/fact-sheets/detail/lead-poisoning-and-health#:~:text=Leadexposurecanhaveserious,intellectualdisabilityandbehaviouraldisorders. Accessed 6 Jul 2023
World Health Organization (2021b) A global overview of national regulations and standards for drinking-water quality, 2nd edn. https://www.who.int/publications/i/item/9789240023642. Accessed 06 July 2023
Yabanlı M, Şener İ, Yozukmaz A et al (2021) Heavy metals in processed seafood products from Turkey: risk assessment for the consumers. Environ Sci Pollut Res 28:53171–53180. https://doi.org/10.1007/s11356-021-14569-z
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I would like to thank Ege University Scientific Research Projects Coordination for their support in the realization of this project (17-FEN-076).
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The study conception, design, material preparation, data collection and analysis were performed by Tülin DENİZ ÇİFTÇİ. The manuscript was also written by Tülin DENİZ ÇİFTÇİ.
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Çiftçi, T.D. Determination of heavy metals and essential elements in nasal sprays and drops (Saline/Sea Water) and evaluation in terms of toxicity. Environ Sci Pollut Res 30, 96938–96947 (2023). https://doi.org/10.1007/s11356-023-29133-0
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DOI: https://doi.org/10.1007/s11356-023-29133-0