Abstract
Antibiotic residues in aquatic environments pose a potential hazard, and microbes, which play important roles in aquatic ecosystems, are vulnerable to the impacts of antibiotics. This study aimed to analyze the research progress, trends, and hot topics of the impact of antibiotics on microbial community and biodegradation mechanism using bibliometric analysis. An in-depth analysis of the publication characteristics of 6143 articles published between 1990 and 2021 revealed that the number of articles published increased exponentially. The research sites have been mainly concentrated in the Yamuna River, Pearl River, Lake Taihu, Lake Michigan, Danjiangkou Reservoir, etc., illustrating that research around the world is not even. Antibiotics could change the diversity, structure, and ecological functions of bacterial communities, stimulate a widespread abundance of antibiotic-resistant bacteria and antibiotic-resistant genes, and increase the diversity of eukaryotes, thus triggering the shift of food web structure to predatory and pathogenic. Latent Dirichlet allocation theme model analysis showed three clusters, and the research hotspots mainly included the effect of antibiotics on the denitrification process, microplastics combined with antibiotics, and methods for removing antibiotics. Furthermore, the mechanisms of microbe-mediated antibiotic degradation were unraveled, and importantly, we provided bottlenecks and future research perspectives on antibiotics and microbial diversity research.
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All data generated or analyzed during this study are included in this published article [and its supplementary information files].
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Abbreviations
- ARGs:
-
Antibiotic resistance genes
- PCA:
-
Principal component analysis
- LDA:
-
Latent Dirichlet allocation
- ARB:
-
Antibiotic resistant bacteria
- CWs:
-
Constructed wetlands
- LRRs:
-
Lakes, reservoirs, or rivers
- AOA:
-
Ammonia-oxidizing archaea
- AOB:
-
Ammonia-oxidizing bacteria
- WWTPs:
-
Wastewater treatment plants
References
Agunbiade FO, Moodley B (2016) Occurrence and distribution pattern of acidic pharmaceuticals in surface water, wastewater, and sediment of the Msunduzi River, Kwazulu-Natal, South Africa. Environ Toxicol Chem 35(1):36–46. https://doi.org/10.1002/etc.3144
Aydin S (2016) Enhanced biodegradation of antibiotic combinations via the sequential treatment of the sludge resulting from pharmaceutical wastewater treatment using white-rot fungi Trametes versicolor and Bjerkandera adusta. Appl Microbiol Biot 100:6491–6499. https://doi.org/10.1007/s00253-016-7473-0
Carvalho IT, Santos L (2016) Antibiotics in the aquatic environments: a review of the European scenario. Environ Int 94:736–757. https://doi.org/10.1016/j.envint.2016.06.025
Chakraborty P, Abraham J (2017) Comparative study on degradation of norfloxacin and ciprofloxacin by Ganoderma lucidum JAPC1. Korean J Chem Eng 34:1122–1128. https://doi.org/10.1007/s11814-016-0345-6
Chen J, Xie S (2018) Overview of sulfonamide biodegradation and the relevant pathways and microorganisms. Sci Total Environ 640:1465–1477. https://doi.org/10.1016/j.scitotenv.2018.06.016
Chen Z, Yu D, He S, Ye H, Zhang L, Wen Y, Zhang W, Shu L, Chen S (2017) Prevalence of antibiotic-resistant Escherichia coli in drinking water sources in Hangzhou City. Front Microbiol 8:1133. https://doi.org/10.3389/fmicb.2017.01133
Danner MC, Robertson A, Behrends V, Reiss J (2019) Antibiotic pollution in surface fresh waters: occurrence and effects. Sci Total Environ 664:793–804. https://doi.org/10.1016/j.scitotenv.2019.01.406
Deng Y, Debognies A, Zhang Q, Zhang Z, Zhou Z, Zhang J, Sun L, Lu T, Qian H (2022) Effects of ofloxacin on the structure and function of freshwater microbial communities. Aquat Toxicol 244:106084–106084. https://doi.org/10.1016/j.aquatox.2022.106084
Ding C, Ma J, Jiang W, Zhao H, Shi M, Cui G, Yan T, Wang Q, Li J, Qiu Z (2021) Chironomidae larvae: a neglected enricher of antibiotic resistance genes in the food chain of freshwater environments. Environ Poll 285. https://doi.org/10.1016/j.envpol.2021.117486
Ding C, He J (2010) Effect of antibiotics in the environment on microbial populations. Appl Microbiol Biot 87(3):925–941. https://doi.org/10.1007/s00253-010-2649-5
Feinerer I, Hornik K, Meyer D (2008) Text mining infrastructure in R. J Stat Softw 25(5):1–54. https://doi.org/10.18637/jss.v025.i05
Feng N-X, Yu J, Xiang L, Yu L-Y, Zhao H-M, Mo C-H, Li Y-W, Cai Q-Y, Wong M-H, Li QX (2019) Co-metabolic degradation of the antibiotic ciprofloxacin by the enriched bacterial consortium XG and its bacterial community composition. Sci Total Environ 665:41–51. https://doi.org/10.1016/j.scitotenv.2019.01.322
Feng C, Chen H, Huang L, Feng Y, Chang S (2022) The research landscape of multiple endocrine neoplasia type 1 (2000–2021): a bibliometric analysis. Front Med 9:832662. https://doi.org/10.3389/fmed.2022.832662
Fischer K, Majewsky M (2014) Cometabolic degradation of organic wastewater micropollutants by activated sludge and sludge-inherent microorganisms. Appl Microbiol Biot 98(15):6583–6597. https://doi.org/10.1007/s00253-014-5826-0
Fu X, Liu G, Guo Y, Guo W (2013) Multi-aspect topic sentiment analysis of Chinese blog. J Chin Inf Process 27(1):47–55. https://doi.org/10.1016/j.knosys.2012.08.003
Fu L, Mao S, Chen F, Zhao S, Su W, Lai G, Yu A, Lin C-T (2022) Graphene-based electrochemical sensors for antibiotic detection in water, food and soil: a scientometric analysis in CiteSpace (2011–2021). Chemosphere 297:134127. https://doi.org/10.1016/j.chemosphere.2022.134127
Gamon F, Cema G, Ziembinska-Buczynska A (2022) The influence of antibiotics on the anammox process - a review. Environ Sci Pollut Res 29(6):8074–8090. https://doi.org/10.1007/s11356-021-17733-7
Garcia J, Jesus Garcia-Galan M, Day JW, Boopathy R, White JR, Wallace S, Hunter RC (2020) A review of emerging organic contaminants (EOCs), antibiotic resistant bacteria (ARB), and antibiotic resistance genes (ARGs) in the environment: increasing removal with wetlands and reducing environmental impacts. Bioresour Technol 307:123228. https://doi.org/10.1016/j.biortech.2020.123228
Gros M, Mas-Pla J, Boy-Roura M, Geli I, Domingo F, Petrovic M (2019) Veterinary pharmaceuticals and antibiotics in manure and slurry and their fate in amended agricultural soils: findings from an experimental field site (Baix Emporda, NE Catalonia). Sci Total Environ 654:1337–1349. https://doi.org/10.1016/j.scitotenv.2018.11.061
Guo X, Song R, Lu S, Liu X, Chen J, Wan Z, Bi B (2022) Multi-media occurrence of antibiotics and antibiotic resistance genes in East Dongting Lake. Front Environ Sci 10:866332. https://doi.org/10.3389/fenvs.2022.866332
Guo N, Liu M, Yang Z, Wu D, Chen F, Wang J, Zhu Z, Wang L (2023) The synergistic mechanism of 8-lactam antibiotic removal between ammonia-oxidizing microorganisms and heterotrophs. Environ Res 216:114419. https://doi.org/10.1016/j.envres.2022.114419
Harrower J, McNaughtan M, Hunter C, Hough R, Zhang Z, Helwig K (2021) Chemical fate and partitioning behavior of antibiotics in the aquatic environment-a review. Environ Toxicol Chem 40:3275–3298. https://doi.org/10.1002/etc.5191
He Y, Yuan Q, Mathieu J, Stadler L, Senehi N, Sun R, Alvarez PJJ (2020) Antibiotic resistance genes from livestock waste: occurrence, dissemination, and treatment. Npj Clean Water 3:4. https://doi.org/10.1038/s41545-020-0051-0
Henriksson PJG, Rico A, Troell M, Klinger DH, Buschmann AH, Saksida S, Chadag MV, Zhang W (2018) Unpacking factors influencing antimicrobial use in global aquaculture and their implication for management: a review from a systems perspective. Sustain Sci 13:1105–1120. https://doi.org/10.1007/s11625-017-0511-8
Hossain A, Nakamichi S, Habibullah-Al-Mamun M, Tani K, Masunaga S, Matsuda H (2017) Occurrence, distribution, ecological and resistance risks of antibiotics in surface water of finfish and shellfish aquaculture in Bangladesh. Chemosphere 188:329–336. https://doi.org/10.1016/j.chemosphere.2017.08.152
Hu YR, Jiang L, Sun XY, Wu JQ, Ma L, Zhou YB, Lin KF, Luo Y, Cui CZ (2021) Risk assessment of antibiotic resistance genes in the drinking water system. Sci Total Environ 800:15. https://doi.org/10.1016/j.scitotenv.2021.149650
Huang L, Chen K, Zhou M (2020) Climate change and carbon sink: a bibliometric analysis. Environ Sci Pollut Res 27(8):8740–8758. https://doi.org/10.1007/s11356-019-07489-6
Hui C, Li Y, Zhang W, Zhang C, Niu L, Wang L, Zhang H (2022) Modelling structure and dynamics of microbial community in aquatic ecosystems: the importance of hydrodynamic processes. J Hydrol 605:127351. https://doi.org/10.1016/j.jhydrol.2021.127351
Hut E-F, Radulescu M, Pilut N, Macasoi I, Berceanu D, Coricovac D, Pinzaru I, Cretu O, Dehelean C (2021) Two antibiotics, ampicillin and tetracycline, exert different effects in HT-29 colorectal adenocarcinoma cells in terms of cell viability and migration capacity. Curr Oncol 28(4):2466–2480. https://doi.org/10.3390/curroncol28040225
Ji B, Zhao Y, Vymazal J, Mander U, Lust R, Tang C (2021) Mapping the field of constructed wetland-microbial fuel cell: a review and bibliometric analysis. Chemosphere 262:128366. https://doi.org/10.1016/j.chemosphere.2020.128366
Kang J, Zhang Z, Chen Y, Zhou Z, Zhang J, Xu N, Zhang Q, Lu T, Peijnenburg WJGM, Qian H (2022) Machine learning predicts the impact of antibiotic properties on the composition and functioning of bacterial community in aquatic habitats. Sci Total Environ 828:154412. https://doi.org/10.1016/j.scitotenv.2022.154412
Kayal A, Mandal S (2022) Microbial degradation of antibiotic: future possibility of mitigating antibiotic pollution. Environ Monit Assess 194:639. https://doi.org/10.1007/s10661-022-10314-2
Kumar JA, Krithiga T, Sathish S, Renita AA, Prabu D, Lokesh S, Geetha R, Namasivayam SKR, Sillanpaa M (2022) Persistent organic pollutants in water resources: fate, occurrence, characterization and risk analysis. Sci Total Environ 831:154808. https://doi.org/10.1016/j.scitotenv.2022.154808
Kunhikannan S, Thomas CJ, Franks AE, Mahadevaiah S, Kumar S, Petrovski S (2021) Environmental hotspots for antibiotic resistance genes. Microbiologyopen 10(3):e1197. https://doi.org/10.1002/mbo3.1197
Laurens C, Jean-Pierre H, Licznar-Fajardo P, Hantova S, Godreuil S, Martinez O, Jumas-Bilak E (2018) Transmission of IMI-2 carbapenemase-producing Enterobacteriaceae from river water to human. J Glob Antimicrib Resist 15:88–92. https://doi.org/10.1016/j.jgar.2018.06.022
Leonard AFC, Morris D, Schmitt H, Gaze WH (2022) Natural recreational waters and the risk that exposure to antibiotic resistant bacteria poses to human health. Curr Opin Microbiol 65:40–46. https://doi.org/10.1016/j.mib.2021.10.004
Li S, Shi WZ, You MT, Zhang RJ, Kuang YZ, Dang CY, Sun WL, Zhou YH, Wang WJ, Ni JR (2019) Antibiotics in water and sediments of Danjiangkou Reservoir, China: spatiotemporal distribution and indicator screening. Environ Poll 246:435–442. https://doi.org/10.1016/j.envpol.2018.12.038
Li H, Xu H, Song H-L, Lu Y, Yang X-L (2020) Antibiotic resistance genes, bacterial communities, and functions in constructed wetland-microbial fuel cells: responses to the co-stresses of antibiotics and zinc. Environ Poll 265(Pt B):115084. https://doi.org/10.1016/j.envpol.2020.115084
Li W, Li J, Li J, Lyu B, Zhang Y (2020) Pollution characteristics of antibiotics in different environment media in China: a review. J Nanjing For Univ. Nat Sci Ed 44(1):205–214. https://doi.org/10.1007/s10661-019-7660-4
Li J, Li W, Liu K, Guo Y, Ding C, Han J, Li P (2022) Global review of macrolide antibiotics in the aquatic environment: sources, occurrence, fate, ecotoxicity, and risk assessment. J Hazard Mater 439:129628–129628. https://doi.org/10.1016/j.jhazmat.2022.129628
Li S, Peng L, Yang C, Song S, Xu Y (2022) Cometabolic biodegradation of antibiotics by ammonia oxidizing microorganisms during wastewater treatment processes. J Environ Manage 305(567):114336. https://doi.org/10.1016/j.jenvman.2021.114336
Li SJ, Peng L, Yang CG, Song SX, Xu YF (2022) Cometabolic biodegradation of antibiotics by ammonia oxidizing microorganisms during wastewater treatment processes. J Environ Manage 305:114336. https://doi.org/10.1016/j.jenvman.2021.114336
Liao X, Li B, Zou R, Dai Y, Xie S, Yuan B (2016) Biodegradation of antibiotic ciprofloxacin: pathways, influential factors, and bacterial community structure. Environ Sci Pollut Res 23(8):7911–7918. https://doi.org/10.1007/s11356-016-6054-1
Liu X, Lu S, Guo W, Xi B, Wang W (2018) Antibiotics in the aquatic environments: a review of lakes, China. Sci Total Environ 627:1195–1208. https://doi.org/10.1016/j.scitotenv.2018.01.271
Liu L, Li J, Fan HY, Huang X, Wei LL, Liu CX (2019) Fate of antibiotics from swine wastewater in constructed wetlands with different flow configurations. Int Biodeter Biodegr 140:119–125. https://doi.org/10.1016/j.ibiod.2019.04.002
Liu T, He XL, Jia GY, Xu JW, Quan X, You SJ (2020) Simultaneous nitrification and denitrification process using novel surface-modified suspended carriers for the treatment of real domestic wastewater. Chemosphere. 247:125831. https://doi.org/10.1016/j.chemosphere.2020.125831
Liu Y, Liu W, Yang X, Wang J, Lin H, Yang Y (2021) Microplastics are a hotspot for antibiotic resistance genes: progress and perspective. Sci Total Environ 773:145643. https://doi.org/10.1016/j.scitotenv.2021.145643
Liu L, Yu X, Wu D, Su J (2022) Antibiotic resistance gene profile in aerobic granular reactor under antibiotic stress: can eukaryotic microalgae act as inhibiting factor? Environ Poll 304:119221. https://doi.org/10.1016/j.envpol.2022.119221
Lu T, Zhu Y, Ke M, Peijnenburg WJGM, Zhang M, Wang T, Chen J, Qian H (2019) Evaluation of the taxonomic and functional variation of freshwater plankton communities induced by trace amounts of the antibiotic ciprofloxacin. Environ Int 126:268–278. https://doi.org/10.1016/j.envint.2019.02.050
Ma J, Cui Y, Li A, Zou X, Ma C, Chen Z (2022) Antibiotics and antibiotic resistance genes from wastewater treated in constructed wetlands. Ecol Eng 177:106548. https://doi.org/10.1016/j.ecoleng.2022.106548
Marathe NP, Pal C, Gaikwad SS, Jonsson V, Kristiansson E, Larsson DGJ (2017) Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics. Water Res 124:388–397. https://doi.org/10.1016/j.watres.2017.07.060
Markley JL, Wencewicz TA (2018) Tetracycline-inactivating enzymes. Front Microbiol 9:1058. https://doi.org/10.3389/fmicb.2018.01058
Michael I, Rizzo L, McArdell CS, Manaia CM, Merlin C, Schwartz T, Dagot C, Fatta-Kassinos D (2013) Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: a review. Water Res 47(3):957–995. https://doi.org/10.1016/j.watres.2012.11.027
Mittal P, Vishnu Prasoodanan PK, Dhakan DB, Kumar S, Sharma VK (2019) Metagenome of a polluted river reveals a reservoir of metabolic and antibiotic resistance genes. Environ Microbiome 14(1):1–12. https://doi.org/10.1186/s40793-019-0345-3
Nkoom M, Lu G, Liu J (2018) Occurrence and ecological risk assessment of pharmaceuticals and personal care products in Taihu Lake, China: a review. Environ Sci Process Impacts 20(12):1640–1648. https://doi.org/10.1039/c8em00327k
Nnadozie CF, Odume ON (2019) Freshwater environments as reservoirs of antibiotic resistant bacteria and their role in the dissemination of antibiotic resistance genes. Environ Poll 254:113067. https://doi.org/10.1016/j.envpol.2019.113067
Ohore OE, Qin Z, Sanganyado E, Wang Y, Jiao X, Liu W, Wang Z (2022) Ecological impact of antibiotics on bioremediation performance of constructed wetlands: microbial and plant dynamics, and potential antibiotic resistance genes hotspots. J Hazard Mater 424:127495. https://doi.org/10.1016/j.jhazmat.2021.127495
Ohore OE, Qin ZR, Sanganyado E, Wang YW, Jiao XY, Liu WH, Wang Z (2022) Vertical characterisation of phylogenetic divergence of microbial community structures, interaction, and sustainability in estuary and marine ecosystems. Sci Total Environ 851(Pt 2):158369. https://doi.org/10.1016/j.scitotenv.2022.158369
Ohore OE, Wei Y, Wang Y, Nwankwegu AS, Wang Z (2022c) Tracking the influence of antibiotics, antibiotic resistomes, and salinity gradient in modulating microbial community assemblage of surface water and the ecological consequences. Chemosphere 305. https://doi.org/10.1016/j.chemosphere.2022.135428
Patel AK, Katiyar R, Chen CW, Singhania RR, Awasthi MK, Bhatia S, Bhaskar T, Dong CD (2022) Antibiotic bioremediation by new generation biochar: recent updates. Bioresour Technol 358:127384. https://doi.org/10.1016/j.biortech.2022.127384
Peng K, Deng JM, Gong ZJ, Qin BQ (2019) Characteristics and development trends of ecohydrology in lakes and reservoirs: insights from bibliometrics. Ecohydrology. 12(3):e2080. https://doi.org/10.1002/eco.2080
Prieto A, Moder M, Rodil R, Adrian L, Marco-Urrea E (2011) Degradation of the antibiotics norfloxacin and ciprofloxacin by a white-rot fungus and identification of degradation products. Bioresour Technol 102(23):10987–10995. https://doi.org/10.1016/j.biortech.2011.08.055
Proia L, Anzil A, Subirats J, Borrego C, Farrè M, Llorca M, Balcázar J, Servais P (2018) Antibiotic resistance along an urban river impacted by treated wastewaters. Sci Total Environ 628–629:453–466. https://doi.org/10.1016/j.scitotenv.2018.02.083
Qin ZR, Zhao ZH, Xia LL, Ohore OE (2022) Research trends and hotspots of aquatic biofilms in freshwater environment during the last three decades: a critical review and bibliometric analysis. Environ Sci Pollut Res 29(32):47915–47930. https://doi.org/10.1007/s11356-022-20238-6
Rui D, Yan W, Wu Y, Xiao Y, Gang H, Wang S, Chen L, Feng Z (2018) Light-excited photoelectrons coupled with bio-photocatalysis enhanced the degradation efficiency of oxytetracycline. Water Research. 143:589–598. https://doi.org/10.1016/j.watres.2018.06.068
Schofield CJ (2018) Antibiotics as food for bacteria. Nat Microbiol 3(7):752–753
Singh R, Singh AP, Kumar S, Giri BS, Kim K-H (2019) Antibiotic resistance in major rivers in the world: a systematic review on occurrence, emergence, and management strategies. J Clean Prod 234:1484–1505. https://doi.org/10.1016/j.jclepro.2019.06.243
Song C, Li L, Zhang C, Kamira B, Qiu L, Fan L, Wu W, Meng S, Hu G, Chen J (2017) Occurrence and human dietary assessment of sulfonamide antibiotics in cultured fish around Tai Lake, China. Environ Sci Pollution R 24:17493–17499. https://doi.org/10.1007/s11356-017-9442-2
Sun Y, Cao N, Duan C, Wang Q, Ding C, Wang J (2021) Selection of antibiotic resistance genes on biodegradable and non-biodegradable microplastics. J Hazard Mater 409:124979. https://doi.org/10.1016/j.jhazmat.2020.124979
Van Boeckel TP, Brower C, Gilbert M, Grenfell BT, Levin SA, Robinson TP, Teillant A, Laxminarayan R (2015) Global trends in antimicrobial use in food animals. Proc Nati Acad Sci usa 112:5649–5654. https://doi.org/10.1073/pnas.1503141112
Varsos C, Patkos T, Oulas A, Pavloudi C, Gougousis A, Ijaz UZ, Filiopoulou I, Pattakos N, Berghe EV, Fernandez-Guerra A, Faulwetter S, Chatzinikolaou E, Pafilis E, Bekiari C, Doerr M, Arvanitidis C (2016) Optimized R functions for analysis of ecological community data using the R virtual laboratory (RvLab). Biodivers Data J (4):e8357. https://doi.org/10.3897/BDJ.4.e8357
Wang R, Ji M, Zhai H, Guo Y, Liu Y (2021) Occurrence of antibiotics and antibiotic resistance genes in WWTP effluent-receiving water bodies and reclaimed wastewater treatment plants. Sci Total Environ 796:148919. https://doi.org/10.1016/j.scitotenv.2021.148919
Wang J, Zhang S, Mu X, Hu X, Ma Y (2022) Research characteristics on cyanotoxins in inland water: insights from bibliometrics. Water 14(4):667. https://doi.org/10.3390/w14040667
Wang N, Peng L, Gu Y, Liang C, Pott RWM, Xu Y (2023) Insights into biodegradation of antibiotics during the biofilm-based wastewater treatment processes. J Clean Prod 393:136321. https://doi.org/10.1016/j.jclepro.2023.136321
Wu Y, Feng P, Li R, Chen X, Li X, Sumpradit T, Liu P (2019) Progress in microbial remediation of antibiotic-residue contaminated environment. Sheng wu gong cheng xue bao 35(11):2133–2150. https://doi.org/10.13345/j.cjb.190164
Xiang SZ, Wang XS, Ma W, Liu XP, Zhang B, Huang FY, Liu F, Guan XY (2020) Response of microbial communities of karst river water to antibiotics and microbial source tracking for antibiotics. Sci Total Environ 706:135730. https://doi.org/10.1016/j.scitotenv.2019.135730
Xiao G, Chen J, Show PL, Yang Q, Liu YJC (2021) Evaluating the application of antibiotic treatment using algae-algae/activated sludge system. Chemosphere. 282:130966. https://doi.org/10.1016/j.chemosphere.2021.130966
Xu Z, Li T, Bi J, Wang C (2018) Spatiotemporal heterogeneity of antibiotic pollution and ecological risk assessment in Taihu Lake Basin, China. Sci Total Environ 643:12–20. https://doi.org/10.1016/j.scitotenv.2018.06.175
Xu S, Zhang T, Yan R, Wang R, Yi Q, Shi W, Gao Y, Zhang Y (2022) Environmental filtering dominated the antibiotic resistome assembly in river networks. Sci Total Environ 834:155293
Xu T, Zhao W, Guo X, Zhang H, Hu S, Huang Z, Yin D (2020) Characteristics of antibiotics and antibiotic resistance genes in Qingcaosha Reservoir in Yangtze River Delta, China. Environ Sci Eur 32(1). https://doi.org/10.1016/j.scitotenv.2022.155293.
Yang QL, Gao Y, Ke J, Show PL, Ge YH, Liu YH, Guo RX, Chen JQ (2021) Antibiotics: an overview on the environmental occurrence, toxicity, degradation, and removal methods. Bioengineered 12(1):7376–7416. https://doi.org/10.1080/21655979.2021.1974657
Zainab SM, Junaid M, Xu N, Malik RN (2020) Antibiotics and antibiotic resistant genes (ARGs) in groundwater: a global review on dissemination, sources, interactions, environmental and human health risks. Water Res 187:116455. https://doi.org/10.1016/j.watres.2020.116455
Zhang Q-Q, Ying G-G, Pan C-G, Liu Y-S, Zhao J-L (2015) Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance. Environ Sci Technol 49(11):6772–6782. https://doi.org/10.1021/acs.est.5b00729
Zhang Y, Cabilio P, Nadeem K (2016) Advances in time series methods and applications: the A. Ian Mcleod Festschrift. Li, W.K., Stanford, D.A. and Yu, H. (eds), 215–229. https://doi.org/10.1007/978-1-4939-6568-7
Zheng F, Zhu D, Giles M, Daniell T, Neilson R, Zhu Y-G, Yang X-R (2019) Mineral and organic fertilization alters the microbiome of a soil nematode Dorylaimus stagnalis and its resistome. Sci Total Environ 680:70–78. https://doi.org/10.1016/j.scitotenv.2019.04.384
Zhou L-J, Han P, Yu Y, Wang B, Men Y, Wagner M, Wu QL (2019) Cometabolic biotransformation and microbial-mediated abiotic transformation of sulfonamides by three ammonia oxidizers. Water Res 159:444–453. https://doi.org/10.1016/j.watres.2019.05.031
Zhou L, Xu P, Gong J, Huang S, Chen W, Fu B, Zhao Z, Huang X (2022) Metagenomic profiles of the resistome in subtropical estuaries: co-occurrence patterns, indicative genes, and driving factors. Sci Total Environ 810:152263. https://doi.org/10.1016/j.scitotenv.2021.152263
Zhu T-T, Su Z-X, Lai W-X, Zhang Y-B, Liu Y-W (2021) Insights into the fate and removal of antibiotics and antibiotic resistance genes using biological wastewater treatment technology. Sci Total Environ 776:145906. https://doi.org/10.1016/j.scitotenv.2021.145906
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This work was financially supported by the project “The key technology of full consumption and harmless disposal of urban food waste” of the National Key Research and Development Program of China (2021YFC1910403).
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Xiaoying Mu: Conceptualization, methodology, writing—original draft, and writing—review and editing; Zhihua Huang, Okugbe Ebiotubo Ohore, Jinjin Yang, Kai Peng, and Shaokang Li: writing—review and editing; Xiang Li: conceptualization, supervision, funding acquisition, and writing—review and editing.
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Mu, X., Huang, Z., Ohore, O.E. et al. Impact of antibiotics on microbial community in aquatic environment and biodegradation mechanism: a review and bibliometric analysis. Environ Sci Pollut Res 30, 66431–66444 (2023). https://doi.org/10.1007/s11356-023-27018-w
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DOI: https://doi.org/10.1007/s11356-023-27018-w