Abstract
Mycotoxins are fungal secondary metabolites that frequently occur in human and animal diets. Deoxynivalenol (DON) is one of the most widely occurring mycotoxins globally and poses significant harm to the animal husbandry industry and human health. People are increasingly aware of the adverse effects of DON on vulnerable structures and functions in the intestine, especially in the field of intestinal stem cells (ISCs). In this review, we present insights into DON that induces oxidative stress and affects the expansion of ISCs. Related studies of strategies for reducing its harm are summarized. We also discussed promising approaches such as regulation of microbiota, molecular docking, and modulation of the redox status via reducing the expression of Keap1 protein and single-cell sequencing, which may be critical for further revealing the mechanism of DON that induces oxidative stress and affects the expansion of ISCs.
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This work was supported by the National Natural Science Foundation of China (32072777, 31872389), the Basic and Applied Basic Research Foundation of Guangdong Province (2019B1515210021), and the Science and Technology Planning Project of Guangzhou (SL2022B03J01334).
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Xiu-qi Wang had the idea for the article and critically revised the work and Shao-jie Liang performed the literature search and finished the manuscript.
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Liang, Sj., Wang, Xq. Deoxynivalenol induces intestinal injury: insights from oxidative stress and intestinal stem cells. Environ Sci Pollut Res 30, 48676–48685 (2023). https://doi.org/10.1007/s11356-023-26084-4
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DOI: https://doi.org/10.1007/s11356-023-26084-4