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Elucidating the promising role of traditional Chinese medicine in neuroprotection against oxidative stress encompassing Alzheimer’s disease

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Abstract

Medicinal plants are being used from time immemorial for their therapeutic benefits and have immense value in the therapy of neurodegenerative disorders. One of the most important neurological disorders is Alzheimer’s disease (AD) which is a major contributor to dementia and is accompanied by abundant oxidative stress in the brain tissue. A critical pathway to target the increased oxidative stress is to administer agents with antioxidant potential. Despite currently available clinical treatments to treat AD such as cholinesterase inhibitors or NMDA antagonists which address only the symptoms and cannot hamper disease progression, no efficient available clinical treatment can break the vicious cycle of oxidative stress and neurodegeneration till date. The main objective of presenting this review is that traditional Chinese medicine (TCM) acts as a promising candidate in breaking this vicious cycle and improves the quality of life of the debilitating patients. The active constituents of various herbs in TCM including Angelica sinensis, Radix polygalae, Polygala tenuifolia, and members of the Lamiaceae family have acquired experience of managing oxidative stress as indicated in the review for more than a thousand years now, and the preclinical and clinical evidence of their therapeutic potential has been highlighted in the review. Most importantly, Chinese herbs provide a multiple-target approach rather than a single-target approach and thus can target multiple pathways involved in AD at once. The Chinese herbs can definitely untangle the issues in the current therapy regimen of AD.

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Acknowledgements

The authors would like to thank Chitkara College of Pharmacy, Chitkara University, Punjab, India, for providing facilities for completion of this review.

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Authors and Affiliations

  1. Chitkara College of Pharmacy, Chitkara University, Punjab, India

    Arpita Arora

  2. School of Health Science and Technology, University of Petroleum and Energy Studies, Bidholi, Dehradun, Uttarakhand, India

    Tapan Behl

  3. GHG Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab, India

    Aayush Sehgal

  4. Department of Pharmaceutics, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, Haryana, India

    Sukhbir Singh & Neelam Sharma

  5. Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah, Kingdom of Saudi Arabia

    Ahmed A. H. Abdellatif

  6. Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Asyut, Egypt

    Ahmed A. H. Abdellatif

  7. Research and Scientific Studies Unit, College of Nursing, Jazan University, Jazan, Saudi Arabia

    Hamad Ghaleb Dailah

  8. Natural & Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, Nizwa, Oman

    Saurabh Bhatia & Ahmed Al-Harrasi

  9. Centre for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai, India

    Saurabh Bhatia

  10. Chrono-Environment Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, Besançon, France

    Lotfi Aleya

  11. Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania

    Simona Bungau

  12. Doctoral School of Biomedical Sciences, University of Oradea, Oradea, Romania

    Simona Bungau

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Contributions

AA and TB: conceived the study and wrote the first draft of the paper; SS, NS, AAH, and HGD: data compilation; AS, SB, and AAH: figure work; LA and SBU: proof read.

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Correspondence to Tapan Behl.

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Arora, A., Behl, T., Sehgal, A. et al. Elucidating the promising role of traditional Chinese medicine in neuroprotection against oxidative stress encompassing Alzheimer’s disease. Environ Sci Pollut Res 30, 39546–39557 (2023). https://doi.org/10.1007/s11356-023-25800-4

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