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A spectrofluorimetric method for the determination of pindolol in natural waters using various organic and cyclodextrin media

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Abstract

A simple, sensitive, and rapid spectrofluorimetric method was developed for the determination of the β-blocker pindolol. The native fluorescence of pindolol was measured in different organic solvents and in cyclodextrin aqueous media. The highest fluorescence signal was obtained in 2-propanol at λem = 303 nm with λex = 260 nm. Analytical figures of merit for the spectrofluorimetric determination of pindolol were satisfactory, with wide linear dynamic range (LDR) values of two orders of magnitude, and rather low limit of detection (LOD) values between 0.2 and 8.7 ng/mL. Moreover, the addition of cyclodextrins (HP-β-CD and β-CD) in aqueous media enhanced the fluorescence of pindolol. In addition, the inclusion complexes of pindolol with cyclodextrins were investigated and the stability constants of complexes were calculated by means of the method of nonlinear regression (NLR). The method was successfully applied to the analysis of tap water and natural water samples, spiked with pindolol.

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Acknowledgements

One of us (C. Gueye) thanks the Service of Cooperation and Cultural Action (SAC) of the French Embassy in Dakar (Senegal) for a French Cooperation PhD grant.

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Authors and Affiliations

  1. Laboratoire Géomatériaux et Environnement (LGE), EA 4119, Université Paris-Est Marne-la-Vallé, 5 Boulevard Descartes, Bâtiment IFI, 77454, Marne-la-Vallée Cedex 2, France

    Coumba Gueye, Jean-Jacques Aaron, Mame Diabou Gaye-Seye, Nihal Oturan & Mehmet A. Oturan

  2. Laboratoire de Photochimie et d’Analyse, Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta Diop, Dakar, Senegal

    Coumba Gueye, Mame Diabou Gaye-Seye & Lamine Cisse

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  1. Coumba Gueye
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  2. Jean-Jacques Aaron
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  4. Lamine Cisse
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Contributions

Coumba Gueye: Thesis experimental work and contribution to paper preparation

J.-J. Aaron: Direction of the work, paper preparation, corrections and corresponding author

M.D. Gaye-Seye: Framing of the work and contribution to the paper preparation

L. Cisse: Framing of the work

N. Oturan: Contribution to the experimental work

M.A. Oturan: Contribution to the experimental work

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Correspondence to Jean-Jacques Aaron.

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Gueye, C., Aaron, JJ., Gaye-Seye, M.D. et al. A spectrofluorimetric method for the determination of pindolol in natural waters using various organic and cyclodextrin media. Environ Sci Pollut Res 28, 55029–55040 (2021). https://doi.org/10.1007/s11356-021-14801-w

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