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Protective effects of selenium and zinc against potassium dichromate–induced thyroid disruption, oxidative stress, and DNA damage in pregnant Wistar rats

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Abstract

Hexavalent chromium (CrVI) is an environmental pollutant and an endocrine-disrupting metal. Se and Zn are essential trace elements, known to play a crucial role in thyroid homeostasis. However, there is a lack of data reporting thyrotoxicity during gestation. In this study, we investigated the protective effects of selenium and zinc against potassium dichromate–induced thyrotoxicity in pregnant Wistar rats. Thirty pregnant Wistar rats were divided into control and four treated groups receiving subcutaneously (s.c) on the 3rd day of pregnancy, K2Cr2O7 (10 mg/kg, s.c) alone, or in association with Se (0.3 mg/kg, s.c), ZnCl2 (20 mg/kg, s.c), or both of them simultaneously. The hormonal profile, oxidative stress biomarkers, DNA damage, and histological modifications were evaluated. Our main findings showed that K2Cr2O7 promoted hypothyroidism, oxidative stress, genotoxicity, and histological alterations in the thyroid gland. The co-treatment with Se or ZnCl2 has mitigated K2Cr2O7-induced thyrotoxicity in pregnant Wistar rats by exhibiting antioxidant and genoprotective effects. However, the combined co-treatment of both of them was less thyroprotective, and therefore, further investigations on the synergetic interaction of Se and Zn against CrVI toxicity using different doses and exposure routes are required.

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The data that support the findings of this study are available from the corresponding author upon request.

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Funding

This work was supported by the DGRSDT/MESRS (code: N ° E2212600).

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Authors and Affiliations

  1. Laboratory of Cellular and Molecular Physiotoxicology-Biomolecules, Faculty of Science of Nature and Life, Department of Biology of Organisms, University of Batna 2, Fesdis, 5000, Batna, Algeria

    Anfal Fedala & Ounassa Adjroud

  2. Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia

    Salwa Abid-Essefi & Rim Timoumi

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  1. Anfal Fedala
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  2. Ounassa Adjroud
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  3. Salwa Abid-Essefi
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  4. Rim Timoumi
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Contributions

Anfal Fedala and Ounassa Adjroud designed the experiment; Anfal Fedala and Rim Timoumi performed the experiment; Anfal Fedala, Ounassa Adjroud, Salwa Abid-Essefi, and Rim Timoumi analyzed the data; Anfal Fedala and Ounassa Adjroud wrote the manuscript; Ounassa Adjroud and Salwa Abid Essefi revised the manuscript; and all authors read and approved the final manuscript.

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Correspondence to Anfal Fedala.

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Fedala, A., Adjroud, O., Abid-Essefi, S. et al. Protective effects of selenium and zinc against potassium dichromate–induced thyroid disruption, oxidative stress, and DNA damage in pregnant Wistar rats. Environ Sci Pollut Res 28, 22563–22576 (2021). https://doi.org/10.1007/s11356-020-12268-9

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  • DOI: https://doi.org/10.1007/s11356-020-12268-9

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