Abstract
Ketoconazole is an imidazole fungicide which is commonly used as pharmaceutical and healthcare products. Residual amount of this compound can cause adverse ecological health problems. The present study investigated ketoconazole photocatalytic degradation using Ag3PO4/graphene oxide (GO). Ag3PO4/GO and Ag3PO4 as visible light-driven photocatalysts was synthesized using the in situ growth method. Degradation of ketoconazole at the concentration of 1–20 mg/L in aqueous solutions was optimized in the presence of Ag3PO4/GO nanocomposite with the dosage of 0.5–2 g/L, contact time of 15–20 min, and pH of 5–9 using response surface methodology. A second-order model was selected as the best fitted model with R2 value and lack of fit as 0.935 and 0.06, respectively. Under the optimized conditions, the Ag3PO4/GO catalyst achieved a photocatalytic efficiency of 96.53% after 93.34 min. The photocatalytic activity, reaction kinetics, and stability were also investigated. The results indicated that the Ag3PO4/GO nanocomposite exhibited higher photocatalytic activity for ketoconazole degradation, which was 2.4 times that of pure Ag3PO4. Finally, a direct Z-scheme mechanism was found to be responsible for enhanced photocatalytic activity in the Ag3PO4/GO nanocomposite. The high photocatalytic activity, acceptable reusability, and good aqueous stability make the Ag3PO4/GO nanocomposite a promising nanophotocatalyst for photocatalytic degradation of azoles contaminants.
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References
Almasi A, Dargahi A, Mohamadi M, Biglari H, Amirian F, Raei M (2016) Removal of Penicillin G by combination of sonolysis and photocatalytic (sonophotocatalytic) process from aqueous solution: process optimization using RSM (response surface methodology). Electron Physician 8:2878. https://doi.org/10.19082/2878
Bakre PV, Volvoikar PS, Vernekar AA, Tilve S (2016) Influence of acid chain length on the properties of TiO2 prepared by sol-gel method and LC-MS studies of methylene blue photodegradation. J Colloid Interface Sci 474:58–67. https://doi.org/10.1016/j.jcis.2016.04.011
Chen ZF, Ying GG (2015) Occurrence, fate and ecological risk of five typical azole fungicides as therapeutic and personal care products in the environment: a review. Environ Int 84:142–153. https://doi.org/10.1016/j.envint.2015.07.022
Chen Z-F, Ying G-G, Ma Y-B, Lai H-J, Chen F, Pan C-G (2013) Occurrence and dissipation of three azole biocides climbazole, clotrimazole and miconazole in biosolid-amended soils. Sci Total Environ 452:377–383. https://doi.org/10.1016/j.scitotenv.2013.03.004
Chen Z-F et al (2014) Photodegradation of the azole fungicide fluconazole in aqueous solution under UV-254: Kinetics, mechanistic investigations and toxicity evaluation. Water Res 52:83–91. https://doi.org/10.1016/j.watres.2013.12.039
Chen X-j, Dai Y-z, Wang X-y, Guo J, Liu T-h, Li F-f (2015a) Synthesis and characterization of Ag3PO4 immobilized with graphene oxide (GO) for enhanced photocatalytic activity and stability over 2, 4-dichlorophenol under visible light irradiation. J Hazard Mater 292:9–18. https://doi.org/10.1016/j.jhazmat.2015.01.032
Chen X, Dai Y, Wang X (2015b) Methods and mechanism for improvement of photocatalytic activity and stability of Ag3PO4: a review. J Alloys Compd 649:910–932. https://doi.org/10.1016/j.jallcom.2015.07.174
Chong MN, Jin B, Chow CW, Saint C (2010) Recent developments in photocatalytic water treatment technology: a review. Water Res 44:2997–3027. https://doi.org/10.1016/j.watres.2010.02.039
da Silva WL, Lansarin MA, Livotto PR, dos Santos JHZ (2015) Photocatalytic degradation of drugs by supported titania-based catalysts produced from petrochemical plant residue. Powder Technol 279:166–172. https://doi.org/10.1016/j.powtec.2015.03.045
Deng Y, Zhao R (2015) Advanced oxidation processes (AOPs) in wastewater treatment. Curr Pollut Rep 1:167–176. https://doi.org/10.1007/s40726-015-0015-z
Dinh C-T, Nguyen T-D, Kleitz F, Do T-O (2011) Large-scale synthesis of uniform silver orthophosphate colloidal nanocrystals exhibiting high visible light photocatalytic activity. Chem Commun 47:7797–7799. https://doi.org/10.1039/C1CC12014J
Ebrahimi M et al (2016) Improved solar-driven photocatalytic activity of hybrid graphene quantum dots/ZnO nanowires: a direct Z-scheme mechanism. ACS Sustain Chem Eng 5:367–375. https://doi.org/10.1021/acssuschemeng.6b01738
Enayatifard R, Khalili N, Rahimizadeh M, Akbari J (2011) A kinetics study of the chemical stability of ketoconazole in aqueous solutions by spectrophotometric method. Analy Chem Lett 1:370–374. https://doi.org/10.1080/22297928.2011.10648240
Gaya UI, Abdullah AH (2008) Heterogeneous photocatalytic degradation of organic contaminants over titanium dioxide: a review of fundamentals, progress and problems. J Photochem Photobiol C: Photochem Rev 9:1–12. https://doi.org/10.1016/j.jphotochemrev.2007.12.003
Ge M (2014) Photodegradation of rhodamine B and methyl orange by Ag3PO4 catalyst under visible light irradiation. Chin J Catal 35:1410–1417. https://doi.org/10.1016/S1872-2067(14)60079-6
Ghanbarian M, Nabizadeh R, Nasseri S, Shemirani F, Mahvi AH, Beyki MH, Mesdaghinia A (2017) Potential of amino-riched nano-structured MnFe2O4@ cellulose for biosorption of toxic Cr (VI): Modeling, kinetic, equilibrium and comparing studies. Int J Biol Macromol 104:465–480. https://doi.org/10.1016/j.ijbiomac.2017.06.060
Gholibegloo E et al (2018) Carnosine-graphene oxide conjugates decorated with hydroxyapatite as promising nanocarrier for ICG loading with enhanced antibacterial effects in photodynamic therapy against Streptococcus mutans. J Photochem Photobiol B Biol 181:14–22. https://doi.org/10.1039/C2CP42465G10.1016/j.jphotobiol.2018.02.004
Ghosh S (2018) Visible-light-active photocatalysis: nanostructured catalyst design, mechanisms, and applications;Wiley-VCH: Weinheim, Germany.
Huang G-F et al (2013) Ag 3 PO 4 semiconductor photocatalyst: possibilities and challenges. J Nanomater 2013:1. https://doi.org/10.1155/2013/371356
Jyoti K, Baunthiyal M, Singh A (2016) Characterization of silver nanoparticles synthesized using Urtica dioica Linn. leaves and their synergistic effects with antibiotics. J Radiat Res Appl Sci 9:217–227. https://doi.org/10.1016/j.jrras.2015.10.002
Kahle M, Buerge IJ, Hauser A, Muller MD, Poiger T (2008) Azole fungicides: occurrence and fate in wastewater and surface waters. Environ Sci Technol 42:7193–7200. https://doi.org/10.1021/es8009309
Kathiravan MK, Salake AB, Chothe AS, Dudhe PB, Watode RP, Mukta MS, Gadhwe S (2012) The biology and chemistry of antifungal agents: a review. Bioorg Med Chem 20:5678–5698. https://doi.org/10.1016/j.bmc.2012.04.045
Lenth RV (2009) Response-Surface Methods in R, using rsm. J Stat Softw 32:1–17. https://doi.org/10.18637/jss.v032.i07
Li X, Shen R, Ma S, Chen X, Xie J (2018) Graphene-based heterojunction photocatalysts. Appl Surf Sci 430:53–107. https://doi.org/10.1016/j.apsusc.2017.08.194
Liang Q, Shi Y, Ma W, Li Z, Yang X (2012) Enhanced photocatalytic activity and structural stability by hybridizing Ag 3 PO 4 nanospheres with graphene oxide sheets. Phys Chem Chem Phys 14:15657–15665. https://doi.org/10.1039/C2CP42465G
Liu B, Fang Y, Li Z, Xu S (2015) Visible-light nanostructured photocatalysts—a review. J Nanosci Nanotechnol 15:889–920. https://doi.org/10.1166/jnn.2015.9784
Low J, Jiang C, Cheng B, Wageh S, Al-Ghamdi AA, Yu J (2017) A review of direct Z-scheme photocatalysts. Small Methods 1:1700080. https://doi.org/10.1002/smtd.201700080
Malakootian M, Gharaghani MA, Dehdarirad A, Khatami M, Ahmadian M, Heidari MR, Mahdizadeh H (2019a) ZnO nanoparticles immobilized on the surface of stones to study the removal efficiency of 4-nitroaniline by the hybrid advanced oxidation process (UV/ZnO/O3). J Mol Struct 1176:766–776. https://doi.org/10.1016/j.molstruc.2018.09.033
Malakootian M, Nasiri A, Amiri Gharaghani M (2019b) Photocatalytic degradation of ciprofloxacin antibiotic by TiO2 nanoparticles immobilized on a glass plate. Chem Eng Commun:1–17. https://doi.org/10.1080/00986445.2019.1573168
Malakootian M, Olama N, Nasiri A (2019c) Photocatalytic degradation of metronidazole from aquatic solution by TiO 2-doped Fe 3+ nano-photocatalyst International. J Environ Sci Technol 16:4275–4284. https://doi.org/10.1007/s13762-018-1836-2
Matthiessen P, Weltje L (2015) A review of the effects of azole compounds in fish and their possible involvement in masculinization of wild fish populations. Crit Rev Toxicol 45:453–467. https://doi.org/10.3109/10408444.2015.1018409
Myers RH, Montgomery DC, Anderson-Cook CM (2016) Response surface methodology: process and product optimization using designed experiments. John Wiley and Sons ( Fourth Edition)
Naeem K, Feng O (2009) Parameters effect on heterogeneous photocatalysed degradation of phenol in aqueous dispersion of TiO2. J Environ Sci 21:527–533. https://doi.org/10.1016/S1001-0742(08)62303-7
Nishiyama N, Fujiwara Y, Adachi K, Inumaru K, Yamazaki S (2015) Preparation of porous metal-ion-doped titanium dioxide and the photocatalytic degradation of 4-chlorophenol under visible light irradiation. Appl Catal B Environ 176:347–353. https://doi.org/10.1016/j.apcatb.2015.04.015
Olga P, Vesna R, Zoran K (2013) A review: current analytical methods for determination of ketoconazole in pharmaceutical and biological samples. IJPI’s J Analy Chem 3:1–14
Panigrahy B, Srivastava S (2016) Minuscule weight percent of graphene oxide and reduced graphene oxide modified Ag 3 PO 4: new insight into improved photocatalytic activity. New J Chem 40:3370–3384. https://doi.org/10.1039/C5NJ03118D
Peng X, Huang Q, Zhang K, Yu Y, Wang Z, Wang C (2012) Distribution, behavior and fate of azole antifungals during mechanical, biological, and chemical treatments in sewage treatment plants in China. Sci Total Environ 426:311–317. https://doi.org/10.1016/j.scitotenv.2012.03.067
Sahoo PK, Panigrahy B, Bahadur D (2014) Facile synthesis of reduced graphene oxide/Pt–Ni nanocatalysts: their magnetic and catalytic properties. RSC Adv 4:48563–48571. https://doi.org/10.1039/C4RA07686A
Shi L et al (2016) Facile synthesis of graphene–enwrapped Ag3PO4 composites with highly efficient visible light photocatalytic performance. Nano 11:1650001. https://doi.org/10.1142/S1793292016500016
Song C, Li X, Wang L, Shi W (2016) Fabrication, characterization and response surface method (RSM) optimization for tetracycline photodegration by Bi3.84W0.16O6.24- graphene oxide (BWO-GO). Sci Rep 6:37466. https://doi.org/10.1038/srep37466
Stamatis N, Antonopoulou M, Konstantinou I (2015) Photocatalytic degradation kinetics and mechanisms of fungicide tebuconazole in aqueous TiO2 suspensions. Catal Today 252:93–99. https://doi.org/10.1016/j.cattod.2014.09.023
Suib SL (2013) New and future developments in catalysis: catalysis for remediation and environmental concerns. Elsevier Amsterdam, The Netherlands.
Sun J, Meng D, Jiang S, Wu G, Yan S, Geng J, Huang Y (2012) Multiple-bilayered RGO–porphyrin films: From preparation to application in photoelectrochemical cells. J Mater Chem 22:18879–18886. https://doi.org/10.1039/C2JM33900E
Thakare SR, Gaikwad G, Khati N, Wankhade A (2015) Development of new, highly efficient and stable visible light active photocatalyst Ag2ZrO3 for methylene blue degradation. Catal Commun 62:39–43. https://doi.org/10.1016/j.catcom.2014.12.027
Wang C, Meng D, Sun J, Memon J, Huang Y, Geng J (2014a) Graphene wrapped TiO2 based catalysts with enhanced photocatalytic activity. Adv Mater Interfaces 1:1300150. https://doi.org/10.1002/admi.201300150
Wang C et al (2014b) Photocatalytic degradation of bisphenol A and dye by graphene-oxide/Ag3PO4 composite under visible light irradiation. Ceram Int 40:8061–8070. https://doi.org/10.1016/j.ceramint.2013.12.159
Wei N, Cui H, Wang M, Wang X, Song X, Ding L, Tian J (2017) Highly efficient photocatalytic activity of Ag 3 PO 4/Ag/ZnS (en) 0.5 photocatalysts through Z-scheme photocatalytic mechanism. RSC Adv 7:18392–18399. https://doi.org/10.1039/C7RA01001J
Xiang Q, Lang D, Shen T, Liu F (2015) Graphene-modified nanosized Ag3PO4 photocatalysts for enhanced visible-light photocatalytic activity and stability. Appl Catal B Environ 162:196–203. https://doi.org/10.1016/j.apcatb.2014.06.051
Xu Y, Bai H, Lu G, Li C, Shi G (2008) Flexible graphene films via the filtration of water-soluble noncovalent functionalized graphene sheets. J Am Chem Soc 130:5856–5857. https://doi.org/10.1021/ja800745y
Xu L, Huang W-Q, Wang L-L, Huang G-F (2014a) Interfacial interactions of semiconductor with graphene and reduced graphene oxide: CeO2 as a case study. ACS Appl Mater Interfaces 6:20350–20357. https://doi.org/10.1021/am5058772
Xu L, Huang W-Q, Wang L-L, Huang G-F, Peng P (2014b) Mechanism of superior visible-light photocatalytic activity and stability of hybrid Ag3PO4/graphene nanocomposite. J Phys Chem C 118:12972–12979. https://doi.org/10.1021/jp5034273
Xu D, Cheng B, Cao S, Yu J (2015) Enhanced photocatalytic activity and stability of Z-scheme Ag2CrO4-GO composite photocatalysts for organic pollutant degradation. Appl Catal B Environ 164:380–388. https://doi.org/10.1016/j.apcatb.2014.09.051
Xu Q, Zhang L, Yu J, Wageh S, Al-Ghamdi AA, Jaroniec M (2018) Direct Z-scheme photocatalysts: principles, synthesis, and applications. Mater Today 21:1042–1063. https://doi.org/10.1016/j.mattod.2018.04.008
Yang L, Liya EY, Ray MB (2008) Degradation of paracetamol in aqueous solutions by TiO2 photocatalysis. Water Res 42:3480–3488. https://doi.org/10.1016/j.watres.2008.04.023
Yu X, Lu Z, Wu D, Yu P, He M, Chen T, Shi W, Huo P, Yan Y, Feng Y (2014) Heteropolyacid–chitosan/TiO 2 composites for the degradation of tetracycline hydrochloride solution. React Kinet Mech Catal 111:347–360. https://doi.org/10.1007/s11144-013-0631-9
Yu W, Xu D, Peng T (2015) Enhanced photocatalytic activity of gC 3 N 4 for selective CO 2 reduction to CH 3 OH via facile coupling of ZnO: a direct Z-scheme mechanism. J Mater Chem A 3:19936–19947. https://doi.org/10.1039/C5TA05503B
Zhou L, Alvarez OG, Mazon CS, Chen L, Deng H, Sui M (2016) The roles of conjugations of graphene and Ag in Ag 3 PO 4-based photocatalysts for degradation of sulfamethoxazole. Cataly Sci Technol 6:5972–5981. https://doi.org/10.1039/C2CP42465G10.1039/C6CY00192K
Zúñiga-Benítez H, Aristizábal-Ciro C, Peñuela GA (2016) Heterogeneous photocatalytic degradation of the endocrine-disrupting chemical benzophenone-3: parameters optimization and by-products identification. J Environ Manag 167:246–258. https://doi.org/10.1016/j.jenvman.2015.11.047
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The authors declare that they have no conflict of interest.
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This research was financially supported by the Tehran University of Medical Sciences, the Center for Water Quality Research, the Institute for Environmental Research, under the project no. 95-04-46-33499.
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Nourieh, N., Nabizadeh, R., Faramarzi, M.A. et al. Photocatalytic degradation of ketoconazole by Z-scheme Ag3PO4/graphene oxide: response surface modeling and optimization. Environ Sci Pollut Res 27, 250–263 (2020). https://doi.org/10.1007/s11356-019-06812-5
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DOI: https://doi.org/10.1007/s11356-019-06812-5