Skip to main content
Log in

The breast milk lead levels among Chinese population

  • Review Article
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

Abstract

Breast milk is a potential source of infant and young children lead exposure, but national-level data on breast milk lead (BML) is unknown in China. To fill up this gap, we conducted a review by analyzing the articles enrolled through searching Wanfang MedOnline, CNKI, SinoMed, Pubmed, and Embase databases and relevant articles from 2000 through 2017. After screening and assessing process, 17 articles were included. The average concentrations of BML in these studies varied with regions (1.54–171.84 μg/L), and the BML level was dropping down in general. In conclusion, breast milk should still be encouraged to infant and young children in normal areas of China, and stopping breastfeeding should be considered prudently. Education for health workers and families on BML should be strengthened, and more surveys on BML should be conducted.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • CDC (2010) Guidelines for the identification and management of lead exposure in pregnant and lactating women. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta

    Google Scholar 

  • Chang JL, Wang Y (2016) National Nutrition and Health Survey 2010–2013. Peking University Medical Press, Beijing

    Google Scholar 

  • Chao HH, Guo CH, Huang CB, Chen PC, Li HC, Hsiung DY, Chou YK (2014) Arsenic, cadmium, lead, and aluminium concentrations in human milk at early stages of lactation. Pediatr Neonatol 55:127–134. https://doi.org/10.1016/j.pedneo.2013.08.005

    Article  Google Scholar 

  • Chen GX, Zeng GZ, Li J (2006) Correlations of blood lead levels in infant, in maternal blood and in breast milk. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 40:189–191 [in Chinese]

    CAS  Google Scholar 

  • Deng B, Zhang HM, Yan CR, Zhang LS, Zhang JQ (2009) Levels of mineral elements composition and heavy metal pollution in human breast milk in Shenzhen City. Journal of Hygiene Research 38:293–295 [in Chinese]

    Google Scholar 

  • Ettinger AS, Tellez-Rojo MM, Amarasiriwardena C, Gonzalez-Cossio T, Peterson KE, Aro A, Hu H, Hernandez-Avila M (2004) Levels of lead in breast milk and their relation to maternal blood and bone lead levels at one month postpartum. Environ Health Perspect 112:926–931

    Article  CAS  Google Scholar 

  • Ettinger AS, Tellez-Rojo MM, Amarasiriwardena C, Peterson KE, Schwartz J, Aro A, Hu H, Hernandez-Avila M (2006) Influence of maternal bone lead burden and calcium intake on levels of lead in breast milk over the course of lactation. Am J Epidemiol 163:48–56. https://doi.org/10.1093/aje/kwj010

    Article  Google Scholar 

  • Ettinger AS, Roy A, Amarasiriwardena CJ, Smith D, Lupoli N, Mercado-Garcia A, Lamadrid-Figueroa H, Tellez-Rojo MM, Hu H, Hernandez-Avila M (2014) Maternal blood, plasma, and breast milk lead: lactational transfer and contribution to infant exposure. Environ Health Perspect 122:87–92. https://doi.org/10.1289/ehp.1307187

    Article  CAS  Google Scholar 

  • Gurbay A, Charehsaz M, Eken A, Sayal A, Girgin G, Yurdakok M, Yigit S, Erol DD, Sahin G, Aydin A (2012) Toxic metals in breast milk samples from Ankara, Turkey: assessment of lead, cadmium, nickel, and arsenic levels. Biol Trace Elem Res 149:117–122. https://doi.org/10.1007/s12011-012-9400-2

    Article  CAS  Google Scholar 

  • Isaac CP, Sivakumar A, Kumar CR (2012) Lead levels in breast milk, blood plasma and intelligence quotient: a health hazard for women and infants. Bull Environ Contam Toxicol 88:145–149. https://doi.org/10.1007/s00128-011-0475-9

    Article  CAS  Google Scholar 

  • Jiao YP, Fu BL, Wen XL, Jiang GFJ, He XQ, Liu L (2011) Analysis on the correlation between lead content in breast milk and lead contents in maternal blood and umbilical cord blood of 500 cases in Guangzhou. Maternal and Child Health Care of China 26:820–821 [in Chinese]

    Google Scholar 

  • Koyashiki GA, Paoliello MM, Tchounwou PB (2010) Lead levels in human milk and children’s health risk: a systematic review. Rev Environ Health 25:243–253

    Article  CAS  Google Scholar 

  • Leotsinidis M, Alexopoulos A, Kostopoulou-Farri E (2005) Toxic and essential trace elements in human milk from Greek lactating women: association with dietary habits and other factors. Chemosphere 61:238–247. https://doi.org/10.1016/j.chemosphere.2005.01.084

    Article  CAS  Google Scholar 

  • Li PJ, Sheng YZ, Wang QY, Gu LY, Wang YL (2000) Transfer of lead via placenta and breast milk in human. Biomed Environ Sci 13:85–89

    CAS  Google Scholar 

  • Li MM, Cao J, Xu J, Cai SZ, Shen XM, Yan CH (2014a) The national trend of blood lead levels among Chinese children aged 0-18 years old, 1990-2012. Environ Int 71:109–117. https://doi.org/10.1016/j.envint.2014.06.005

    Article  CAS  Google Scholar 

  • Li T, Dai YH, Xie XH, Tan ZW, Zhang SM, Zhu ZH (2014b) Surveillance of childhood blood lead levels in 11 cities of China. World J Pediatr 10:29–37. https://doi.org/10.1007/s12519-014-0452-6

    Article  Google Scholar 

  • Li GC, Wang Y, Ping YM, Ji JY, Wang SX, Chen CL, Zhou J (2015) Correlations of lead levels in maternal blood cord blood and colostrum. Zhejiang Practical Medicine 20:358,368 [in Chinese]

    Google Scholar 

  • Li T, Zhang S, Tan Z, Dai Y (2017) Trend of childhood blood lead levels in cities of China in recent 10 years. Environ Sci Pollut Res Int 24:5824–5830. https://doi.org/10.1007/s11356-016-8335-0

    Article  CAS  Google Scholar 

  • Liao GH, Li YH, Li HP, Wang JC, Feng YK (2002) The preliminary study on contont correlatron between lead in serum and lead in early lactation in normal pregnant women in Kunming. Chinese Journal of Birth Health & Heredity 10:26–27 [in Chinese]

    Google Scholar 

  • Lin K, Zhang HM, Jiang J, Li RY, Zhang JQ (2015) Determination of heavy metal elements in breast milk by atomic absorption spectrometry. Practical Preventive Medicine 22:133–136 [in Chinese]

    CAS  Google Scholar 

  • Liu RH, Huang YG, Xiao H, Tang WQ, Cai DH, Huang KR (2004) Matched analysis of lead and calcium level in maternal blood, umbilical blood and breast milk. Chinese Journal of Child Health Care 12:201–203 [in Chinese]. https://doi.org/10.3969/j.issn.1008-6579.2004.03.006

    Article  CAS  Google Scholar 

  • Liu KS, Hao JH, Gu PQ, Sun HJ, Shi J, Dai CF, Liu X, Peng YZ (2012a) The effect of lead levels in the umbilical cord blood and foremilk on the neurobehavioral development of the neonates. Chinese Journal of Birth Health & Heredity:111–115. https://doi.org/10.13404/j.cnki.cjbhh.2012.02.051

  • Liu X, Zhang J, Liu Y, Li Y, Li Z (2012b) The association between cesarean delivery on maternal request and method of newborn feeding in China. PLoS One 7:e37336. https://doi.org/10.1371/journal.pone.0037336

    Article  CAS  Google Scholar 

  • Liu J, Shi Z, Spatz D, Loh R, Sun G, Grisso J (2013a) Social and demographic determinants for breastfeeding in a rural, suburban and city area of South East China. Contemp Nurse 45:234–243. https://doi.org/10.5172/conu.2013.45.2.234

    Article  Google Scholar 

  • Liu KS, Hao JH, Xu YQ, Gu XQ, Shi J, Dai CF, Xu F, Shen R (2013b) Breast milk lead and cadmium levels in suburban areas of Nanjing, China. Chin Med Sci J 28:7–15

    Article  CAS  Google Scholar 

  • Mandour RA, Ghanem AA, El-Azab SM (2013) Correlation between lead levels in drinking water and mothers’ breast milk: Dakahlia, Egypt. Environ Geochem Health 35:251–256. https://doi.org/10.1007/s10653-012-9480-0

    Article  CAS  Google Scholar 

  • Miao H, Cheng WW (2012) Analysis of the lead level of breast milk in Shanghai. Medical Journal of West China 24:1689–1690,1693 [in Chinese]. https://doi.org/10.3969/j.issn.1672-3511.2012.09.013

    Article  Google Scholar 

  • Neville MC, Keller R, Seacat J, Lutes V, Neifert M, Casey C, Allen J, Archer P (1988) Studies in human lactation: milk volumes in lactating women during the onset of lactation and full lactation. Am J Clin Nutr 48:1375–1386

    Article  CAS  Google Scholar 

  • Parr RM, DeMaeyer EM, Iyengar VG, Byrne AR, Kirkbright GF, Schöch G, Niinistö L, Pineda O, Vis HL, Hofvander Y, Omololu A (1991) Minor and trace elements in human milk from Guatemala, Hungary, Nigeria, Philippines, Sweden, and Zaire. Results from a WHO/IAEA joint project. Biol Trace Elem Res 29:51–75. https://doi.org/10.1007/BF03032674

    Article  CAS  Google Scholar 

  • Sakamoto M, Chan HM, Domingo JL, Kubota M, Murata K (2012) Changes in body burden of mercury, lead, arsenic, cadmium and selenium in infants during early lactation in comparison with placental transfer. Ecotoxicol Environ Saf 84:179–184. https://doi.org/10.1016/j.ecoenv.2012.07.014

    Article  CAS  Google Scholar 

  • Sun ZQ, Yue B, Yang ZY, Li XW, Wu YN, Yin SA (2013) Determination of 24 minerals in human milk by inductively coupled plasma mass spectrometry with microwave digestion. Journal of Hygiene Research 42:504–509 [in Chinese]

    CAS  Google Scholar 

  • Tellez-Rojo MM, Hernandez-Avila M, Gonzalez-Cossio T, Romieu I, Aro A, Palazuelos E, Schwartz J, Hu H (2002) Impact of breastfeeding on the mobilization of lead from bone. Am J Epidemiol 155:420–428

    Article  Google Scholar 

  • von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370:1453–1457. https://doi.org/10.1016/s0140-6736(07)61602-x

    Article  Google Scholar 

  • Winiarska-Mieczan A (2014) Cadmium, lead, copper and zinc in breast milk in Poland. Biol Trace Elem Res 157:36–44. https://doi.org/10.1007/s12011-013-9870-x

    Article  CAS  Google Scholar 

  • Xu JZ, Huang L, Wang J, Xu J, Liu XL (2010) A survey on lead level in breast milk in Shenzhen. Guangdong Trace Elements Science 17:18–20 [in Chinese]

    CAS  Google Scholar 

  • Yan Q, Ren J, Yan S (2009) Analysis on the lever of lead and cadmium in blood, urine and milk of 60 cases mothers after labor. Chinese Journal of Child Health Care 17:451–453 [in Chinese]

    Google Scholar 

  • Yang H, Zhang L, Liu LM (2016) Composition of breast milk and infant physical development. Chinese Journal of Woman and Child Health Research 27:154–156 [in Chinese]

    Google Scholar 

  • Yurdakok K (2015) Lead, mercury, and cadmium in breast milk. J Pediatr Neonat Individual Med 4:2281–2692. https://doi.org/10.7363/040223

    Article  Google Scholar 

  • Zhang D (2009) Investigation on heavy metals and nutrient elements of breast milk and the influent factors in eight cities of China, Dissertation, Shanghai Jiaotong University, Shanghai [in Chinese]

  • Zhang LF, Guo XF, Fang W, Wu X, Li QF (2008) Correlation of lead levels in 3-month old infant blood, in maternal blood and breast milk in Jiangmen City, Guangdong Province. Studies of Trace Elements and Health 25:16–19 [in Chinese]

    Google Scholar 

  • Zhang D, Wu MQ, Yan CH, Yu XD, Xu J, Chen GX, Zhang J, Zhou XY (2011) Analysis on the status of trace elements in breast milk. Maternal and Child Health Care of China 26:2652–2655 [in Chinese]

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yao-hua Dai.

Additional information

Responsible editor: Philippe Garrigues

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, T., Tao, Xw., Zhang, Sm. et al. The breast milk lead levels among Chinese population. Environ Sci Pollut Res 25, 20562–20568 (2018). https://doi.org/10.1007/s11356-018-2471-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-018-2471-7

Keywords

Navigation