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Influence of endurance training-induced weight loss on the levels of ghrelin and obestatin of obese women with polycystic ovary syndrome

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Abstract

Background

Polycystic ovary syndrome is an observed plurimetabolic syndrome associated with central obesity and insulin resistance.

Aims

The purpose of the present study was to investigate the effects of 12-week training program on weight loss, serum ghrelin, acylated ghrelin, des-acylated ghrelin, and obestatin levels in obese sedentary women with polycystic ovary syndrome (PCOS).

Methods

To this end, thirty sedentary obese women with PCOS (mean age 31.07 ± 2.49 years, height 162.23 ± 2.39 cm, weight: 87.23 ± 4.48 kg, BMI 33.12 ± 0.92) were recruited from a multidisciplinary PCOS specialty clinic in Tabriz city in 2017 and evaluated before and after a 12-week training program, including 45 min per session of aerobic training at an intensity of 60–75% of age-predicted maximum heart rate (300 kcal/day).

Results

After the exercise program, body weight, waist circumference, and percentage body fat mass were decreased. Also, fasting glucose, insulin, and serum acylated ghrelin levels were significantly decreased (P < 0.05), but serum obestatin levels were significantly increased after training program (P < 0.05). Furthermore, serum ghrelin and des-acylated ghrelin concentrations were not significantly changed after the training program (P > 0.05).

Conclusions

The moderate aerobic exercise training is associated with improvements in obestatin and health profiles of obese women with PCOS without associated structured energy restriction.

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Abbreviations

PCOS:

Polycystic ovary syndrome

T2DM:

Type 2 diabetes

MS:

Metabolic syndrome

COCs:

Combination oral contraceptives

HOMA-IR:

Homeostatic model assessment of insulin resistance

AG:

Acylated ghrelin

DAG:

Des-acylated ghrelin

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Acknowledgements

The study was designed by ZF and FN; data were collected and analyzed by GM; data interpretation and manuscript preparation were undertaken by ZF, FN and GM. All authors approved the final version of the paper.

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  1. Department of Physical Education and Sport Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran

    Farzad Zehsaz, Negin Farhangi & Mehri Gahremani

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  1. Farzad Zehsaz
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This research has been approved by the Medical Committee of the Faculty of Medical Sciences, Islamic Azad University of Tabriz, with the Ethical Code number (56935/5/11/13) and all procedures performed in studies involving human participants were in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Zehsaz, F., Farhangi, N. & Gahremani, M. Influence of endurance training-induced weight loss on the levels of ghrelin and obestatin of obese women with polycystic ovary syndrome. Sport Sci Health 16, 703–711 (2020). https://doi.org/10.1007/s11332-020-00646-2

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