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Effects of different sleep disorders on frailty in the elderly: a systematic review and meta-analysis of observational studies

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Abstract

Study objectives

Frailty is frequently reported following sleep disorders; however, the extent to which sleep disorders influence frailty remains unclear. In the current study, we performed a meta-analysis to evaluate the quantitative effects of different sleep disorders on frailty in the elderly.

Methods

We conducted a systematic search of several databases, including PubMed, Web of Science, Embase, and Scopus, to retrieve articles published from May 2009 to June 2021. The data outcomes are expressed as the odds ratio (OR) and 95% confidence interval (CI).

Results

Eighteen studies were included, with 39669 participants. Older adults with sleep disorders were found to have a higher risk of frailty (pooled OR = 1.49, 95%CI = 1.35–1.64, p < 0.01). Specifically, daytime sleepiness (pooled OR = 1.69, 95%CI = 1.09–2.61, p < 0.01), short sleep duration (pooled OR = 1.36, 95%CI = 1.20–1.54, p = 0.45), long sleep duration (pooled OR = 1.99, 95%CI = 1.39–2.85, p = 0.02), sleep latency extension (pooled OR = 1.38, 95%CI = 1.19–1.60, p = 0.72), and sleep disordered breathing (pooled OR = 1.30, 95%CI = 1.11–1.53, p = 0.37) were correlated with frailty.

Conclusions

The risk of frailty differs between older adults with sleep disorders and controls, suggesting that the relationships between different sleep disorders and frailty vary. These results highlight the need to monitor sleep disorders of the elderly and conduct intervention to prevent or delay the frailty process.

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Acknowledgements

We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.

Funding

This study was funded by the National Key Research and Development Program of China (grant number 2020YFC2005300) and the Clinical Research Fund of Wu Jieping Medical Foundation (grant number 320.6750.2021–18-1).

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Authors and Affiliations

  1. School of Public Health, Fudan University, Shanghai, China

    Ruijia Sun

  2. Xiangya Hospital Central South University, Changsha, China

    Yongqiu Xie & E. Wang

  3. Xiangya School of Public Health, Central South University, Changsha, China

    Wen Jiang & Xingli Li

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  1. Ruijia Sun
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Contributions

Sun, E, Li designed the study; Xie, Jiang collected and checked the data; Sun, Jiang processed and analyzed the data; Sun, Li wrote the paper.

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Correspondence to E. Wang or Xingli Li.

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Sun, R., Xie, Y., Jiang, W. et al. Effects of different sleep disorders on frailty in the elderly: a systematic review and meta-analysis of observational studies. Sleep Breath 27, 91–101 (2023). https://doi.org/10.1007/s11325-022-02610-5

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  • DOI: https://doi.org/10.1007/s11325-022-02610-5

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