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Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly

  • Sleep Breathing Physiology and Disorders • Original Article
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A Correction to this article was published on 13 February 2018

This article has been updated

Abstract

Background

Elderly people have a high prevalence to systemic arterial hypertension (SAH) and obstructive sleep apnea (OSA). Both comorbidities are closely associated and inflict damage on cardiorespiratory capacity.

Methods

In order to assess cardiorespiratory responses to the cardiopulmonary exercise test (CPET) among hypertensive elderly with OSA, we enrolled 28 subjects into two different groups: without OSA (No-OSA: apnea/hypopnea index (AHI) < 5 events/h; n = 15) and with OSA (OSA: AHI ≥ 15 events/h; n = 13). All subjects underwent CPET and polysomnographic assessments. After normality and homogeneity evaluations, independent t test and Pearson’s correlation were performed. The significance level employed was p ≤ 0.05.

Results

Hypertensive elderly with OSA presented lower heart rate recovery (HRR) in the second minute (HRR2) in relation to the No-OSA group. A negative correlation between AHI and ventilation (VE) (r = −0.63, p = 0.02) was found in polysomnography and CPET data comparisons, and oxygen saturation (O2S) levels significantly correlated with VE/VCO2slope (r = 0.66, p = 0.01); in addition, No-OSA group presented a positive correlation between oxygen consumption and O2S (r = 0.66, p = 0.01), unlike the OSA group.

Conclusions

OSA does not affect the CPET variables in hypertensive elderly, but it attenuates the HRR2. The association between O2S during sleep with ventilatory responses probably occurs due to the adaptations in the oxygen transport system unleashed via mechanical respiratory feedback; thus, it has been identified that OSA compromises the oxygen supply in hypertensive elderly.

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Change history

  • 13 February 2018

    The original version of this article was published online containing two items that require correction, namely the abstract (Results section) and Table 3.

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Acknowledgements

The authors thank the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior for the scholarship provided for the BTB (2014–2016).

Funding

No funding was received for this research.

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Authors and Affiliations

  1. Laboratory of Physical Training Studies Applied to Health, Physical Education Department, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brazil

    Bruno Teixeira Barbosa, Amilton da Cruz Santos & Maria do Socorro Brasileiro-Santos

  2. Associate Graduate Program in Physical Education UPE/UFPB, João Pessoa, Brazil

    Bruno Teixeira Barbosa, Amilton da Cruz Santos, Eduardo D. S. Freitas & Maria do Socorro Brasileiro-Santos

  3. Physical Education Departament, Federal University of Paraiba, João Pessoa, PB, Brazil

    Amilton da Cruz Santos & Maria do Socorro Brasileiro-Santos

  4. Lauro Wanderley University Hospital, João Pessoa, PB, Brazil

    Murillo Frazão & Tulio Rocha Petrucci

  5. Israelita Albert Einstein Hospital, São Paulo, SP, Brazil

    Gabriel Grizzo Cucato

  6. Heart Institute (InCor), FMUSP, São Paulo, SP, Brazil

    Adriana Oliveira Sarmento

  7. Animal Anatomy and Physiology Department, Universidade Federal Rural de Pernambuco, Recife, PE, Brazil

    Anna Myrna Jaguaribe de Lima

Authors
  1. Bruno Teixeira Barbosa
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  2. Amilton da Cruz Santos
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  3. Murillo Frazão
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  5. Gabriel Grizzo Cucato
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  7. Eduardo D. S. Freitas
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  8. Anna Myrna Jaguaribe de Lima
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  9. Maria do Socorro Brasileiro-Santos
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Correspondence to Maria do Socorro Brasileiro-Santos.

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Barbosa, B.T., da Cruz Santos, A., Frazão, M. et al. Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly. Sleep Breath 22, 431–437 (2018). https://doi.org/10.1007/s11325-017-1557-7

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  • DOI: https://doi.org/10.1007/s11325-017-1557-7

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