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Can treatment with statins have a negative influence on the tolerance of mandibular advancement devices?

  • Dentistry • Short Communication
  • Published:
Sleep and Breathing Aims and scope Submit manuscript

Abstract

Background

Statins are considered the most effective drugs used in the treatment of dyslipidemias. Some of their adverse effects are related to muscle problems. Myalgias produced by statins appear more often during exercise. Mandibular advancement devices (MAD) force the propulsory and elevatory musculature of the mandible to exercise by making the jaw move forward. The aim of this study is to evaluate the incidence of muscular side effects (referred, spontaneous, or under palpation pain, myofascial pain, mandibular rigidity and fatigue, tension and sensitivity of the masticatory muscles) in a group of patients with a diagnosis of obstructive sleep apnea being treated with MAD.

Methods

This was a prospective study, involving consecutively 104 patients with a diagnosis of OSAS, and who had begun treatment with a custom made oral device. Muscular side effects were collected by anamnesis (verbal request and questionnaires), psychological status and clinical assessment (manual muscle palpation in the masticatory and cervical muscle groups), before and during MAD treatment.

Results

Of the total sample, 22.1 % presented muscular side effects with the oral device. However, in patients taking statins, this percentage was 57.1 %, as opposed to 16.7 % of the non-statins patients (p < 0.001). The risk of suffering muscular alterations during oral device treatment is higher in statin patients (odds ratio 6.67, p = 0.002).

Conclusion

Treatment with statins can give rise to the appearance of undesirable side effects among patients being treated with oral devices.

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Acknowledgments

Our thanks to Pedro Muñoz, epidemiologist of the Cantabrian Health Service for his help with the statistical analysis.

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Authors and Affiliations

  1. Sleep and Ventilation Unit, Respiratory Division, Marqués de Valdecilla University Hospital, Santander, Spain

    Mónica González & Marian Martínez-Martínez

  2. Department of Surgery and Medical-Surgical Specialties, Area of Orthodontics, Faculty of Medicine, University of Oviedo, Catedrático Serrano s/n, 33006, Oviedo, Spain

    Emilio Macias-Escalada, Juan Cobo & Felix de Carlos

  3. Department of Stomatology I, Faculty Of Odontology, Basque Country, Leioa, Vizcaya, Spain

    Maria Pilar Fernández Mondragón

  4. Department of Special Care in Dentistry, Pharmacological Research in Dentistry, Faculty of Dentistry, University of Granada, Granada, Spain

    Gerardo Gómez-Moreno

Authors
  1. Mónica González
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  2. Emilio Macias-Escalada
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  3. Juan Cobo
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  4. Maria Pilar Fernández Mondragón
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  5. Gerardo Gómez-Moreno
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  6. Marian Martínez-Martínez
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  7. Felix de Carlos
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Corresponding author

Correspondence to Felix de Carlos.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria, educational grants; participation in speakers bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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González, M., Macias-Escalada, E., Cobo, J. et al. Can treatment with statins have a negative influence on the tolerance of mandibular advancement devices?. Sleep Breath 20, 1363–1366 (2016). https://doi.org/10.1007/s11325-016-1399-8

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  • DOI: https://doi.org/10.1007/s11325-016-1399-8

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