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Quantum Dot-Based Simultaneous Multicolor Imaging

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Abstract

Quantum dots have attracted a great deal of attention among researchers in optical imaging because of their unique physicochemical properties. Their adjustable size allows quantum dots to emit visible fluorescence with different wavelengths excited by a single light source, allowing them to play an unmatched role in multitarget simultaneous multicolor imaging of tissues and cells compared with other molecular biotechnologies and traditional fluorescent materials. This technology affords real-time observation in situ of multiple biomarkers, allowing us to quantify their expression levels, and helping us to gain a deeper understanding of the interactions among biomolecules and the relationship between biomolecules and disease occurrence, progression, and prognosis. This has potential to aid in clinical diagnosis and treatment decision making.

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Acknowledgments

We thank Libby Cone, MD, MA, from Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac) for editing a draft of this manuscript.

Funding

This work was supported by the Key Project of National Natural Science Foundation of China (No. 81630049), the Key Project of Hubei Province Technical Innovation Special Funding (No. 2017ACA182), and the National Science and Technology Support Program (No. 2015BAI01B09).

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Authors and Affiliations

  1. Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Wenxia Wang, Zhen Liu & Xiaoli Lan

  2. Hubei Key Laboratory of Molecular Imaging, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China

    Wenxia Wang, Zhen Liu & Xiaoli Lan

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  1. Wenxia Wang
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  2. Zhen Liu
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Correspondence to Xiaoli Lan.

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Wang, W., Liu, Z. & Lan, X. Quantum Dot-Based Simultaneous Multicolor Imaging. Mol Imaging Biol 22, 820–831 (2020). https://doi.org/10.1007/s11307-019-01432-4

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