Wireless Networks

, Volume 24, Issue 5, pp 1809–1819 | Cite as

Design and wet-laboratory implementation of reliable end-to-end molecular communication

  • Taro Furubayashi
  • Yoshihiro Sakatani
  • Tadashi NakanoEmail author
  • Andrew Eckford
  • Norikazu Ichihashi


This paper describes a novel design and wet laboratory implementation of reliable end-to-end molecular communication. In the reliable end-to-end molecular communication described in this paper, source and destination bio-nanomachines exchange molecular packets through intermediate bio-nanomachines that are capable of packet replication. A source bio-nanomachine forms a molecular packet and transmits the molecular packet into the environment. An intermediate bio-nanomachine detects a molecular packet and produces its copies through packet replication. A destination bio-nanomachine, upon reception of a molecular packet, produces an acknowledgment molecular packet and transmits back to the source bio-nanomachine. This paper describes how the reliable end-to-end molecular communication can be biochemically implemented with RNA (ribonucleic acid) molecules and artificial cell systems. It also describes a simulation-based performance evaluation study showing the impact of model parameters on propagation delay in the reliable end-to-end molecular communication.


Molecular communication Bio-nanomachine Packet replication Ack transmission Artificial cell RNA (ribonucleic acid) 



This work was supported through the Osaka University Humanware Innovation Program, a Leading Graduate School Program by the Japan Society of the Promotion of Science. This work was also supported by JSPS KAKENHI Grant Number JP25240011.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Graduate School of Frontier BiosciencesOsaka UniversityOsakaJapan
  2. 2.Graduate School of Information Science and TechnologyOsaka UniversityOsakaJapan
  3. 3.Department of Electrical Engineering and Computer ScienceYork UniversityTorontoCanada

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