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Bamboo polysaccharides elicit hypocrellin A biosynthesis of a bambusicolous fungus Shiraia sp. S9

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Abstract

Hypocrellin A (HA), a fungal perylenequinone from bambusicolous Shiraia species, is a newly developed photosensitizer for photodynamic therapy in cancer and other infectious diseases. The lower yield of HA is an important bottleneck for its biomedical application. This study is the first report of the enhancement of HA production in mycelium culture of Shiraia sp. S9 by the polysaccharides from its host bamboo which serve as a strong elicitor. A purified bamboo polysaccharide (BPSE) with an average molecular weight of 34.2 kDa was found to be the most effective elicitor to enhance fungal HA production and characterized as a polysaccharide fraction mainly composed of arabinose and galactose (53.7: 36.9). When BPSE was added to the culture at 10 mg/L on day 3, the highest HA production of 422.8 mg/L was achieved on day 8, which was about 4.0-fold of the control. BPSE changed the gene expressions mainly responsible for central carbon metabolism and the cellular oxidative stress. The induced generation of H2O2 and nitric oxide was found to be involved in both the permeabilization of cell membrane and HA biosynthesis, leading to enhancements in both intra- and extracellular HA production. Our results indicated the roles of plant polysaccharides in host-fungal interactions and provided a new elicitation technique to improve fungal perylenequinone production in mycelium cultures.

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The datasets generated and analyzed during this study are included in the published article [and its supplementary information files].

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This work was supported by the National Natural Science Foundation of China (No. 82073955 and 81773696) and the Priority Academic Program Development of the Jiangsu Higher Education Institutes (PAPD).

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  1. College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China

    Wen Hao Shen, Lu Lu Zhou, Xin Ping Li, Rui Peng Cong, Qun Yan Huang & Jian Wen Wang

  2. Department of Horticultural Sciences, Soochow University, Suzhou, 215123, China

    Li Ping Zheng

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JWW and LPZ conceived and designed research. WHS, LLZ, XPL, RPC and QYH undertook experiments and data analysis. WHS and JWW drafted the manuscript. JWW and LPZ supervised the research and revised the paper. All authors discussed the results, commented and approved the final manuscript.

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Shen, W.H., Zhou, L.L., Li, X.P. et al. Bamboo polysaccharides elicit hypocrellin A biosynthesis of a bambusicolous fungus Shiraia sp. S9. World J Microbiol Biotechnol 39, 341 (2023). https://doi.org/10.1007/s11274-023-03789-9

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