Abstract
Bifidobacterium is a major probiotic of intestinal gut flora and exerts many physiological activities, and it is widely applied in the fields of food and medicine. As an important part of Bifidobacterium, glycoside hydrolase plays a role in its physiological activity. With the continuous development and improvement of genetic engineering technology, research on this type of enzyme will play a crucial role in promoting the further development of Bifidobacterium in the field of probiotics. In this review, the preparation methods, enzymatic properties, and functions of glycoside hydrolase extracted from Bifidobacterium are described and summarized. The common method for preparing glycoside hydrolase derived from Bifidobacterium is heterologous expression in Escherichia coli BL21. The optimal pH range for these glycoside hydrolase enzymes is between 4.5 and 7.5; the optimal temperature is between 30 and 50 °C, which is close to the optimal growth condition of Bifidobacterium. Based on substrate specificity, these glycoside hydrolase could hydrolyze synthetic substrates and natural oligosaccharides, including a series of pNP artificial substrates, disaccharide, and trisaccharides, while they have little ability to hydrolyze polysaccharide substrates. This review will be expected to provide a basis for the development of Bifidobacterium as a probiotic element.
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Data availability
The data used in this study have been appropriately stored and are available for sharing upon request. The dataset is available by contacting Huili Hong, email address, honghl117@163.com.
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The authors wish to thank the Natural Science Foundation of Jilin Province (grant number YDZJ202101ZYTS195), and Second Batch of “Climbing Plan” Projects of Changchun University (grant number ZKP202107). for funding part of this work under the research grant.
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All authors made an original contribution to the planning and structure of this review. YH performed the conceptual design and supervised the work. YH and HH, was responsible for writing—original manuscript. JZ is responsible for data collection and literature search. YC and BZ were responsible for the article review. Project management and funding acquisition were handled by YH and JZ. All authors have read and agreed to the submitted version of the manuscript.
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Hu, Y., Hong, H., Zhou, J. et al. Recent advances in enzymatic properties, preparation methods, and functions of glycoside hydrolase from Bifidobacterium: a review. World J Microbiol Biotechnol 39, 344 (2023). https://doi.org/10.1007/s11274-023-03770-6
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DOI: https://doi.org/10.1007/s11274-023-03770-6