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Genomic characterization of a novel bovine papillomavirus type 28

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Abstract

Infection of bovine papillomavirus (BPV) has been associated with mucosal and/or cutaneous tumor development in bovids. To date, up to 27 genotypes of BPVs have been identified and classified based on the nucleotide sequence identity of L1 open reading frame. In the present study, the complete sequence of a novel BPV concurrently identified with BPV1 and BPV2 in the facial cutaneous papilloma lesion of a domestic cattle was characterized. The whole genome of the unclassified BPV was 7263 base pairs in full length with GC ratio of 42.9%. In comparison with published BPV sequences, L1 nucleotide sequence of the novel BPV shared 75% identity with BPV15, and was suggested to be classified in the genus, Xipapillomavirus. According to the criteria established by the International Committee on the Taxonomy of Viruses, the novel BPV was designated as BPV type 28.

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Acknowledgements

We are grateful to the Hyuga Meat Inspection Center of Miyazaki Prefecture for providing the sample.

Funding

This project was partly supported by the agricultural fund from the University of Tokyo.

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Authors and Affiliations

  1. Division of Infection Control and Disease Prevention, Department of Veterinary Medical Science, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan

    Nanako Yamashita-Kawanishi, Masano Tsuzuki, Fumi Kasuya & Takeshi Haga

  2. School of Veterinary Medicine, Graduate Institute of Molecular and Comparative Pathobiology, National Taiwan University, Taipei, Taiwan

    Hui-Wen Chang

Authors
  1. Nanako Yamashita-Kawanishi
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  2. Masano Tsuzuki
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  3. Fumi Kasuya
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  4. Hui-Wen Chang
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  5. Takeshi Haga
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Contributions

TH conceived the study; NYK, MT, and FK performed the experiments; NYK, MT, FK, and HWC analyzed the data; and NYK wrote the manuscript. All authors revised and approved the final manuscript.

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Correspondence to Takeshi Haga.

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The authors declare that they have no conflict of interest.

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Edited by Takeshi Noda.

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Electronic supplementary material

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11262_2020_1779_MOESM1_ESM.pdf

Sequencing primers used to determine the full-genome sequence of BPV28 are noted. The nucleotide position corresponds to the BPV28 full-genome sequence. Supplementary file1 (PDF 51 kb)

11262_2020_1779_MOESM2_ESM.pdf

The respective sequence identities of BPV reference genotypes determined by CLUSTALW tool are shown. Each GenBank accession number is noted in parentheses. Scores showing more than 70 % within Xipapillomavirus 1 -classified BPVs are highlighted. Supplementary file2 (PDF 51 kb)

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Yamashita-Kawanishi, N., Tsuzuki, M., Kasuya, F. et al. Genomic characterization of a novel bovine papillomavirus type 28. Virus Genes 56, 594–599 (2020). https://doi.org/10.1007/s11262-020-01779-9

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  • DOI: https://doi.org/10.1007/s11262-020-01779-9

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