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Genetic characterization of Amazonian bovine papillomavirus reveals the existence of four new putative types

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Abstract

Papillomaviruses are small and complex viruses that belong to the Papillomaviridae family, which comprises 39 genera. The bovine papillomavirus (BPV) causes an infectious disease that is characterized by chronic and proliferative benign tumors that affect cattle worldwide. Different genotypes of BPVs can cause distinct skin and mucosal lesions and the immunity they raise has low cross-protection. This report aimed to genotype BPVs in cattle from Northern Brazil based on nucleotide partial sequences of the L1 ORF. Skin wart samples from 39 bovines clinically and histopathologically diagnosed as cutaneous papillomatosis from Acre and Rondônia States were analyzed. The results revealed four already reported BPV types (BPVs 1, 2, 11, and 13), nine putative new BPV subtypes and four putative new BPV types as well as two putative new BPV types that were already reported. To our knowledge, this is the first record of BPVs from the Brazilian Amazon region that identified new possible BPV types and subtypes circulating in this population. These findings point to the great genetic diversity of BPVs that are present in this region and highlight the importance of this knowledge before further studies about vaccination are attempted.

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Acknowledgments

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo à Pesquisa do Estado do Acre (FAPAC) and Propesq/UFRGS supported this study.

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    Authors and Affiliations

    1. Laboratório de Virologia, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves, 9090, Prédio 42.602, Porto Alegre, Rio Grande do Sul, CEP 91540-000, Brazil

      Flavio R. C. da Silva, Cíntia Daudt, André F. Streck & Matheus N. Weber

    2. Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04 - Distrito Industrial, Rio Branco, CEP 69920-900, Brazil

      Flavio R. C. da Silva

    3. Setor de Patologia, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9090, Prédio 42.505, Porto Alegre, CEP 91540-000, Brazil

      Ronaldo V. Leite Filho, David Driemeier & Cláudio W. Canal

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    1. Flavio R. C. da Silva
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    Correspondence to Cláudio W. Canal.

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    Edited by Keizo Tomonaga.

    Flavio R. C. da Silva and Cíntia Daudt authors equally contributed to this work.

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    da Silva, F.R.C., Daudt, C., Streck, A.F. et al. Genetic characterization of Amazonian bovine papillomavirus reveals the existence of four new putative types. Virus Genes 51, 77–84 (2015). https://doi.org/10.1007/s11262-015-1220-y

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    • DOI: https://doi.org/10.1007/s11262-015-1220-y

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