Dietary Supplements of Vitamins E and C and β-Carotene Reduce Oxidative Stress in Cats with Renal Insufficiency


Oxidative stress may contribute to the progression of chronic renal failure. In this study, cats with spontaneous renal insufficiency were fed a dry cat food supplemented with the antioxidants vitamins E and C, and β-carotene for 4 weeks. When compared with healthy cats, cats with renal insufficiency had a tendency to oxidative stress. The antioxidant supplements significantly reduced DNA damage in cats with renal insufficiency as evidenced by reduced serum 8-OHdG and comet assay parameters. Therefore, supplements of vitamins E and C and β-carotene as antioxidants may be beneficial to cats with renal disease.

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high-performance liquid chromatography




oxygen radical absorption capacity


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Correspondence to S. Yu.

Additional information

Partial data of this study were presented at the Experimental Biology meeting on 17–21 April, 2004. Washington DC, USA

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Yu, S., Paetau-Robinson, I. Dietary Supplements of Vitamins E and C and β-Carotene Reduce Oxidative Stress in Cats with Renal Insufficiency. Vet Res Commun 30, 403–413 (2006).

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  • antioxidants
  • cats
  • DNA damage
  • oxidative stress
  • renal insufficiency