Dietary Supplements of Vitamins E and C and β-Carotene Reduce Oxidative Stress in Cats with Renal Insufficiency

Abstract

Oxidative stress may contribute to the progression of chronic renal failure. In this study, cats with spontaneous renal insufficiency were fed a dry cat food supplemented with the antioxidants vitamins E and C, and β-carotene for 4 weeks. When compared with healthy cats, cats with renal insufficiency had a tendency to oxidative stress. The antioxidant supplements significantly reduced DNA damage in cats with renal insufficiency as evidenced by reduced serum 8-OHdG and comet assay parameters. Therefore, supplements of vitamins E and C and β-carotene as antioxidants may be beneficial to cats with renal disease.

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Abbreviations

8-OHdG:

8-hydroxy-2'-deoxyguanosine

HPLC:

high-performance liquid chromatography

MDA:

malondialdehyde

ORAC:

oxygen radical absorption capacity

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Correspondence to S. Yu.

Additional information

Partial data of this study were presented at the Experimental Biology meeting on 17–21 April, 2004. Washington DC, USA

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Yu, S., Paetau-Robinson, I. Dietary Supplements of Vitamins E and C and β-Carotene Reduce Oxidative Stress in Cats with Renal Insufficiency. Vet Res Commun 30, 403–413 (2006). https://doi.org/10.1007/s11259-006-3269-5

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Keywords

  • antioxidants
  • cats
  • DNA damage
  • oxidative stress
  • renal insufficiency