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Blunted cerebral hemodynamic responses to incremental exercise in patients with end-stage renal disease

  • Nephrology - Original Paper
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Abstract

Purpose

The aims of this study were to compare cerebral hemodynamics and maximal oxygen uptake (VO2peak) in patients with end-stage renal disease (ESRD) vs. age-matched healthy controls during maximal exercise.

Methods

Twelve patients with ESRD and twelve healthy adults (CTR group) performed exhaustive incremental exercise test. Throughout the exercise test, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O2Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the prefrontal cortex.

Results

Compared to CTR, VO2peak was significantly lower in ESRD group (P < 0.05). Increase in ∆THb (i.e., cerebral blood volume) was significantly blunted in ESRD (P < 0.05). ESRD patients also had impaired changes in cerebral ∆HHb and ∆O2Hb during high intensity of exercise (P < 0.05). Finally, no significant correlation was observed between VO2peak and changes in cerebral hemodynamics parameters in both groups (All P > 0.05).

Conclusion

Maximal exercise highlights subtle disorders of both hemodynamics and neuronal oxygenation in the prefrontal cortex in patients with ESRD. This may contribute to both impaired cognitive function and reduced exercise tolerance throughout the progression of the disease.

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Data availability

The data may be shared upon reasonable request to the corresponding author if the request is accepted by the Regional Research Committee for Medical and Health Research Ethics and the local Data Protection Official.

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Acknowledgements

We are thankful to all the participants who dedicated their time and effort to complete this study. We would like to equally acknowledge the contributions of the nurses at Taher Sfar hospital.

Funding

None.

Author information

Authors and Affiliations

  1. Research Laboratory: Education, Motricité, Sport et Santé, EM2S, LR19JS01, High Institute of Sport and Physical Education, University of Sfax, Sfax, Tunisia

    Amal Machfer, Mohamed Amine Bouzid, Nadia Fekih & Hayfa Ben Haj Hassen

  2. Department of Cardiology, Tahar Sfar Hospital, Mahdia, Tunisia

    Hassen Ibn Hadj Amor

  3. Université de Lille, Université d’Artois, Université du Littoral Côte d’Opale, ULR 7369 – URePSSS – Unité de Recherche Pluridisciplinaire Sport, Santé, Société, Lille, France

    Sèmah Tagougui

  4. Montreal Clinical Research Institute (IRCM), Montreal, Canada

    Sèmah Tagougui

  5. Activité Physique, Sport et Santé, UR18JS01, Observatoire National du Sport, 1003, Tunis, Tunisia

    Hamdi Chtourou

Authors
  1. Amal Machfer
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  2. Mohamed Amine Bouzid
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  3. Nadia Fekih
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  4. Hayfa Ben Haj Hassen
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  5. Hassen Ibn Hadj Amor
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  6. Sèmah Tagougui
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  7. Hamdi Chtourou
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Contributions

Study conception and design: all authors. Material preparation and data collection and analysis: Amal Machfer, Mohamed Amine Bouzid, Nadia Fekih. Writing—original draft: Amal Machfer. Writing—review and editing: all authors. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Amal Machfer.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study received approval from the south institutional human research ethics committee (CPP SUD N° 0459/2022)) and followed the ethical principles of the Declaration of Helsinki (2013).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Machfer, A., Bouzid, M.A., Fekih, N. et al. Blunted cerebral hemodynamic responses to incremental exercise in patients with end-stage renal disease. Int Urol Nephrol (2024). https://doi.org/10.1007/s11255-024-03991-0

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