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Short or long sleep duration was associated with chronic kidney disease in a Chinese nationwide cohort study

  • Nephrology - Original Paper
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An Editorial to this article was published on 25 April 2024

Abstract

Objective

Sleep duration is an important factor influencing health outcomes. The association between sleep duration and kidney function remains elusive. This study aimed to explore the association between sleep duration and chronic kidney disease (CKD) amongst Chinese adults.

Methods

We conducted a cross-sectional study based on the China Health and Nutrition Survey (CHNS) in the wave of 2009. Participants were divided into three groups: ≤ 6 h/day (short sleepers), 7–8 h/day (regular sleepers) and ≥ 9 h/day (long sleepers) according to self-reported sleep duration. CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2.

Results

A total of 8096 Chinese adults (45.9% men) with a mean age of 50.6 years were included in the study. Compared with regular sleepers, both short and long regular sleepers had a higher prevalence of CKD. A U-shaped relationship between sleep duration and CKD was displayed by restricted cubic spline curve (P-overall < 0.001, P-nonlinear < 0.001). Multivariate logistic regression models revealed that both short and long sleep duration were clinically associated with higher odds of CKD, after adjustments for covariates [adjusted odds ratio (OR) 1.25 and 1.30; 95% confidence interval (CI) 1.00–1.56 and 1.08–1.54, for short and long sleep duration, respectively]. In subgroup analyses, we found the association was still observed in participants without hypertension or diabetes mellitus.

Conclusion

Short or long sleep duration was associated with CKD in the general population.

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Data availability

The datasets generated during and/or analysed during the current study are available at the website (http://www.cpc.unc.edu/projects/china/home.html).

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Acknowledgements

The authors would like to express sincere appreciation to the Institutional Review Board of the University of North Carolina at Chapel Hill and the National Institute for Nutrition and Food safety at China Center for Disease Control and Prevention for providing original data publicly available.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial or non-for-profit sectors.

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Authors and Affiliations

  1. Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China

    Naling Peng & Shizhen Li

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Both NP and SL contributed to the design, analysis, interpretation, and writing and review of the paper. All authors read and approved the final manuscript.

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Correspondence to Shizhen Li.

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Peng, N., Li, S. Short or long sleep duration was associated with chronic kidney disease in a Chinese nationwide cohort study. Int Urol Nephrol 56, 1695–1701 (2024). https://doi.org/10.1007/s11255-023-03861-1

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