Avoid common mistakes on your manuscript.
Editor,
We are pleased that our article [1] has aroused the interest of Dr. Dong and colleagues and that they raise two important points. We agree that the collective we studied does not meet the requirements to establish valid associations between ADT and cognitive deficits in prostate cancer patients. This includes the inadequacy of our calculations, which failed to account for several possible risk factors.
Accordingly, we pointed out these limitations several times in the discussion. It is obvious that it is not possible within the framework of a cross-sectional study with 58 subjects to clarify complex associations such as those present in patients with advanced prostate cancer and cognitive deficits. Our study did not have this claim either. Our goal was less ambitious. We wanted to contribute more data to this question, as suggested by the ICCTF working group [2]. Our data can now be used in future meta-analyses. Therefore, we also conclude by stating that further research on this topic is needed.
References
Ihrig A, Pernt PM, Zschäbitz S, Huber J, Friederich HC, Bugaj TJ, Maatouk I (2023) Neurocognitive effects of androgen deprivation therapy and new hormonal agents in a sample of patients with metastatic prostate cancer. Int Urol Nephrol. https://doi.org/10.1007/s11255-023-03712-z
Wefel JS, Vardy J, Ahles T, Schagen SB (2011) International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer. Lancet Oncol 12(7):703–708
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Ihrig, A., Pernt, P.M., Zschäbitz, S. et al. Response to the letter to editor: Neurocognitive deficits attributed to androgen deprivation therapy in patients with prostate cancer should be reconsidered. Int Urol Nephrol 56, 145 (2024). https://doi.org/10.1007/s11255-023-03787-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11255-023-03787-8