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Serum irisin level is higher in peritoneal dialysis than in hemodialysis

  • Nephrology - Original Paper
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Abstract

Background

Previous studies have proved that irisin is related to the development of chronic kidney disease. In this study, we aimed to compare serum irisin level in patients treated with peritoneal dialysis (PD) and hemodialysis (HD).

Methods

Two hundred and fifty-two dialysis patients (146 PD patients and 106 HD patients) were included in the study. Levels of serum irisin and other parameters were compared between the two groups’ patients.

Results

There were higher serum irisin levels in PD patients than those in HD patients [113.10 (106.15 ~ 119.15) ng/ml vs. 45.72(21.67 ~ 79.71) ng/ml, P < 0.001]. Moreover, body fat mass, percent body fat, serum calcium, high-density lipoprotein, low-density lipoprotein, carbon dioxide combining power (CO2CP) and residual renal function were higher in patients on PD than that in those on HD, whereas levels of lean body mass, systolic blood pressure, albumin, serum uric acid, potassium, and phosphorus（It should be “were" replace are) are higher in HD patients in comparison to PD patients. Dialysis modality (PD/HD), serum CO2CP level, lean body mass, and percent body fat independently positively correlated with natural logarithm of irisin (lnirisin) by multivariate linear regression analysis.

Conclusions

In this study, we prove that serum irisin level is significantly higher in patients treated with peritoneal dialysis than that with hemodialysis. As well as, increasing skeletal muscle mass and fat body percent, and correcting metabolic acidosis may increase serum irisin levels.

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Data availability

The data that support the findings of this study are available from the corresponding author on reasonable request.

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Acknowledgements

This study was supported by Beijing Municipal Education commission & Beijing Natural Science Foundation (KZ202110025038), and Xuanwu Hospital Huizhi talent leader training program to Aihua Zhang.

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Author notes

  1. Xin-Yu Song and Si-Jia Zhou have contributed equally.

Authors and Affiliations

  1. Department of Nephrology, Xuanwu Hospital, Capital Medical University, Changchun Street 45#, Beijing, 100053, China

    Xin-Yu Song, Jia-Ling Zhang, Ting Zhou, Shi-Yuan Wang, Qi Pang, Ya-Jing Pan & Ai-Hua Zhang

  2. National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China

    Ai-Hua Zhang

  3. Department of Nephrology, Peking University Third Hospital, Beijing, China

    Si-Jia Zhou

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  1. Xin-Yu Song
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Contributions

AHZ and XYS: designed the study. XYS and SJZ: collected the data. XYS: drafted the manuscript. JLZ, TZ and SYW: analyzed the data. QP and YJP: assisted in the literature search. AHZ: revised and supervised all the works. All the authors have read and approved the final version of the manuscript.

Corresponding author

Correspondence to Ai-Hua Zhang.

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The authors have declared that they have no competing interests.

Ethical approval

All the procedures performed in studies involving human participants were in accordance with the ethical standards of the Human Clinical Study Committee of Xuanwu Hospital.

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Informed consent was obtained from all the individual participants included in the study.

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Song, XY., Zhou, SJ., Zhang, JL. et al. Serum irisin level is higher in peritoneal dialysis than in hemodialysis. Int Urol Nephrol 55, 1329–1334 (2023). https://doi.org/10.1007/s11255-022-03440-w

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  • DOI: https://doi.org/10.1007/s11255-022-03440-w

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