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Circulating irisin level in chronic kidney disease patients: a systematic review and meta-analysis

  • Nephrology - Original Paper
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Abstract

Background

Irisin is not only a myokine but also an adipokine that is critical in many diseases including in the development of such diseases as obesity, diabetes mellitus, metabolic syndrome, coronary artery disease, and chronic inflammation. However, the association between irisin and chronic kidney disease (CKD) is unclear. This systematic review aimed to assess circulating irisin levels in patients with CKD and compare them with those in non-CKD patients.

Methods

PubMed, EMBASE, CENTRAL, ISI Web of Science, and CNKI were searched to identify observational studies of circulating irisin levels in patients with CKD. Two reviewers independently searched the databases and screened studies according to the inclusion criteria. Data were extracted using a standardized collection form. Meta-analysis was performed to compare the differences in circulating irisin levels between CKD and non-CKD patients.

Results

A total of 9 studies (6 cross-sectional and 3 case controls) involving 859 CKD patients and 393 non-CKD individuals were selected. The pooled data indicated that circulating irisin concentrations were significantly lower in CKD nondialysis patients (WMD = − 84.79, 95% CI − 170.23, 0.50; p < 0.05), peritoneal dialysis patients (WMD = − 235.81, 95% CI − 421.99, − 49.62; p = 0.01), and hemodialysis patients (WMD = − 217.46, 95% CI − 381.35, − 53.57; p = 0.009) than in healthy controls.

Conclusions

This study confirmed that irisin levels were decreased in patients with CKD. Moreover, circulating irisin levels were lower in dialysis patients than in nondialysis patients.

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Acknowledgements

We thank all the medical, nursing, and technical staff from the Department of Nephrology, Central Hospital of Wuhan.

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Authors and Affiliations

  1. Department of Nephrology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, Hubei, China

    Wenyuan Gan, Wenli Chen, Tianyu Li, Danni Shao, Fang Xu, Shanshan Huo, Chenchen Li, Zhenhua Yang & Xingruo Zeng

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  1. Wenyuan Gan
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  2. Wenli Chen
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  3. Tianyu Li
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  4. Danni Shao
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  5. Fang Xu
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  7. Chenchen Li
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  8. Zhenhua Yang
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Contributions

WG and XZ designed the study; TL and DS collected data; WC had given professional advices on the design and performance of this study; SH, CL, ZY, and FX analyzed the data and made the figures; WG drafted the paper; XZ revised the paper; all authors approved the final version of the manuscript.

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Correspondence to Xingruo Zeng.

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All the authors declare that they have no conflict of interest. No financial contributions were made for this article.

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Gan, W., Chen, W., Li, T. et al. Circulating irisin level in chronic kidney disease patients: a systematic review and meta-analysis. Int Urol Nephrol 54, 1295–1302 (2022). https://doi.org/10.1007/s11255-021-03000-8

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  • DOI: https://doi.org/10.1007/s11255-021-03000-8

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