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Hyperuricemia aggravates the progression of IgA nephropathy

  • Nephrology - Original Paper
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Abstract

Objective

The relationship between hyperuricemia and IgA nephropathy (IgAN) was evaluated systematically in this research.

Methods

The Preferred Reporting Items for Systematic Review and Meta-analysis statement was employed to design and report the study.

Results

Twenty-five studies were included in this meta-analysis with a total of 6048 IgAN patients. The clinical indicators indicated that blood urea nitrogen (BUN) (p < 0.00001, mean difference (MD) = 2.60, 95% confidence interval (CI) 1.74–3.46), serum creatinine (Scr) (p < 0.00001, MD = 44.56, 95% CI 31.15–57.98), diastolic blood pressure(DBP) (p < 0.00001, MD = 3.86, 95% CI 2.84–4.88), systolic blood pressure(SBP) (p < 0.00001, MD = 6.71, 95% CI 4.70–8.71), and 24-h urine protein(24 h TP) (p < 0.00001, MD = 0.76, 95% CI 0.58–0.94) were significantly increased in IgAN with hyperuricemia group than that in normouricemic IgAN group. The pathological analysis indicated that mesangial proliferation (p < 0.00001, MD = 0.12, 95% CI 0.07–0.17), vascular lesion (p < 0.00001, MD = 0.17, 95% CI 0.13–0.20), segmental lesion (p < 0.00001, MD = 0.15, 95% CI 0.03–0.26), tubulointerstitial damage (p < 0.00001, MD = 1.27, 95% CI 1.06–1.48), and glomerulosclerosis (p < 0.00001, MD = 0.56, 95% CI 0.40–0.72) were considerably climbed in IgAN patients with hyperuricemia compared without hyperuricemia group. Additionally, the estimated glomerular filtration rate (p < 0.00001, MD = − 29.03, 95% CI − 36.83 to − 21.23) was decreased in IgAN patients with hyperuricemia compared with normouricemic group.

Conclusion

Hyperuricemia exacerbates IgAN prognosis through aggravating the clinical outcomes and pathological results of IgAN.

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Availability of data and material

All relevant data during this study are included in this article. Further enquiries can be directed to the corresponding author.

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Funding

YFL received a National Natural Science Foundation of China (81701601). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China

    Yin-Hong Geng, Zhe Zhang, Jun-Jun Zhang, Bo Huang, Zui-Shuang Guo, Xu-Tong Wang, Song-Xia Quan, Rui-Min Hu & Ya-Fei Liu

  2. Department of Nephrology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, 19 Renmin Road, Zhengzhou, 450046, Henan, China

    Lin-Qi Zhang

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  1. Yin-Hong Geng
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  2. Zhe Zhang
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Contributions

Data Curation: ZZ, BH, and Z-SG. Formal analysis: Y-HG. Investigation: ZZ and S-XQ. Supervision: Y-FL, X-TW, and R-MH. Writing—original draft: Y-HG. Writing—review and editing: J-JZ, L-QZ, and Y-FL.

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Correspondence to Ya-Fei Liu.

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Geng, YH., Zhang, Z., Zhang, JJ. et al. Hyperuricemia aggravates the progression of IgA nephropathy. Int Urol Nephrol 54, 2227–2237 (2022). https://doi.org/10.1007/s11255-022-03125-4

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