Abstract
Purpose
Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country.
Methods
Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database between May 2009 and June 2019. The data of all PGD patients over the age of 16 years who were diagnosed with renal biopsy and had hematuria data were included in the study. Demographic characteristics, laboratory and biopsy findings were also recorded.
Results
Data of 3394 PGD patients were included in the study. While 1699 (50.1%) patients had hematuria, 1695 (49.9%) patients did not have hematuria. Patients with hematuria had statistically higher systolic blood pressure, serum blood urea nitrogen, creatinine, albumin, levels and urine pyuria. However, these patients had statistically lower age, body mass index, presence of hypertension and diabetes, eGFR, 24-h proteinuria, serum total, HDL and LDL cholesterol, and C3 levels when compared with patients without hematuria. Hematuria was present 609 of 1733 patients (35.8%) among the patients presenting with nephrotic syndrome, while it was presented in 1090 of 1661 (64.2%) patients in non-nephrotics (p < 0.001).
Conclusion
This is the first multicenter national report regarding the demographic and histopathologic data of PGD patients with or without hematuria. Hematuria, a feature of nephritic syndrome, was found at a higher than expected in the PGDs presenting with nephrotic syndrome in our national database.
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Data availability
We created a database for primary glomerular diseases with the name of ‘Turkish Society of Nephrology Glomerular Diseases Working Group (TSN-GOLD) in 04.04.2008. We published the first results of our study in 2012 in Internal Urology and Nephrology [10]. This study is a retrospective study on the epidemiologic data of patients who underwent native kidney biopsy between 2009 and 2019 and diagnosed as ‘primary glomerular disease’ extracted from the ‘Primary Glomerulonephritis Registry of Turkish Society of Nephrology’ database. https://pgh.tsn.org.tr/login.php.
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Concept—K.T., A.S., and S.O.; design—K.T., A.S., and S.O.; supervision—A.T. and S.O.; resources—A.S., E.C., N.E., and K.T.; data collection and/or processing: all the authors from 47 centers; analysis and/or ınterpretation—K.T., A.S., and S.O.; literature search—A.S., E.C., N.E., and K.T.; writing manuscript—K.T., A.S., and S.O. All the authors read and approved the manuscript.
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Sumnu, A., Turkmen, K., Cebeci, E. et al. Characteristics of primary glomerular diseases patients with hematuria in Turkey: the data from TSN-GOLD Working Group. Int Urol Nephrol 53, 945–954 (2021). https://doi.org/10.1007/s11255-020-02690-w
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DOI: https://doi.org/10.1007/s11255-020-02690-w