Abstract
Purpose
Our aim is to evaluate the value of limited bowel preparation (LBP) in radical cystectomy (RC) with ileal urinary diversion (IUD).
Methods
A systematic literature search was conducted on electronic database up to February 2020. All data were analyzed using RevMan5 (version 5.3). A subgroup analysis comparing the efficacy of CBP and no bowel preparation (NBP) was also performed.
Results
Six randomized controlled trials (RCTs) including 743 patients were finally enrolled for statistical analysis. According to the meta-analysis, there was no significant difference between LBP group and comprehensive bowel preparation (CBP) group, concerning operative time (p = 0.79), length of stay (p = 0.46), the time to first toleration of clear liquids (p = 0.95), and overall complications (p = 0.29). However, the time to first bowel activity (SMD: − 0.77, 95% CI − 1.47 to − 0.07, p = 0.03), risk of fever (RR: 0.53, 95% CI 0.33–0.85, p = 0.008), time to first flatus (SMD: − 1.06, 95% CI − 2.02 to − 0.10, p = 0.03), and risk of wound healing disorders (RR: 0.65, 95% CI 0.44–0.95, p = 0.03) were significantly lower in LBP group compared with CBP group. Subgroup analysis showed a significant lower risk of wound healing disorders in favor of NBP (RR: 0.50, 95% CI 0.29–0.87, p = 0.01).
Conclusions
Current evidence indicated that LBP protocols might accelerate recovery of gastrointestinal function, promote wound healing, and reduce the risk of fever without increasing complications in patients undergoing RC with IUD. Besides, bowel preparation also did not hinder wound healing. Further, well-designed RCTs conducted by experienced surgeons are warranted before making the final clinical guidelines.
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References
Huynh D, Henderson A, Haden T et al (2017) Feasibility and safety study for the use of wound protectors during robotic radical cystectomy and ileal conduit. J Robot Surg 11(2):187–191
Tabibi A, Simforoosh N, Basiri A et al (2007) Bowel preparation versus no preparation before ileal urinary diversion. Urology 70(4):654–658
Hewitt J, Reeve J, Rigby J (1973) Whole-gut irrigation in preparation for large-bowel surgery. Lancet 302(7825):337–340
Hj K, Ym Y, Kn P (1994) The changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives. J Korean Med Sci 9(5):388–393
Shafii M, Murphy DM, Donovan MG et al (2002) Is mechanical bowel preparation necessary in patients undergoing cystectomy and urinary diversion? BJU Int 89:879–881
Pruthi RS, Chun J, Richman M (2003) Reducing time to oral diet and hospital discharge in patients undergoing radical cystectomy using a perioperative care plan. Urology 62(4):661–665
Pruthi RS, Nielsen M, Smith A et al (2010) Fast track program in patients undergoing radical cystectomy: results in 362 consecutive patients. J Am Coll Surg 210(1):93–99
Maffezzini M, Gerbi G, Campodonico F et al (2007) Multimodal perioperative plan for radical cystectomy and intestinal urinary diversion. I. Effect on recovery of intestinal function and occurrence of complications. Urology 69(6):1107–1111
Arumainayagam N, McGrath J, Jefferson KP et al (2008) Introduction of an enhanced recovery protocol for radical cystectomy. BJU Int 101(6):698–701
Xu R, Zhao X, Zhong Z et al (2010) No advantage is gained by preoperative bowel preparation in radical cystectomy and ileal conduit: a randomized controlled trial of 86 patients. Int Urol Nephrol 42(4):947–950
Moher D, Shamseer L, Clarke M et al (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 4(1):1
Evidence-Based Cf (2009) Oxford Centre for evidence-based medicine: levels of evidence. https://www.cebm.net/oxford-centreevidence-based-medicine-levels-evidence-march-2009/. Accessed 18 Feb 2020
Karl A, Buchner A, Becker A et al (2014) A new concept for early recovery after surgery for patients undergoing radical cystectomy for bladder cancer: results of a prospective randomized study [J]. J Urol 191(2):335–340
Hashad MM, Atta M, Elabbady A et al (2012) Safety of no bowel preparation before ileal urinary diversion [J]. BJU Int 110:E1109–E1113
Aslan G, Baltaci S, Akdogan B et al (2013) A prospective randomized multicenter study of Turkish society of urooncology comparing two different mechanical bowel preparation methods for radical cystectomy [J]. Urol Oncol 31(5):664–670
Tianxin L, Kaiwen Li, Hao L et al (2018) Enhanced recovery after surgery for radical cystectomy with ileal urinary diversion: a multi-institutional, randomized, controlled trial from the Chinese bladder cancer consortium [J]. World J Urol 36(1):41–50
Jing F, Hao Z, Weiyang He et al (2018) Application of enhanced recovery after surgery in perioperative period of radical cystectomy and evaluation on its effect [J]. J Chongqing Med Univ 43(4):552–555
Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5:13
Lijing Y, Guyan W, Yingjie Du et al (2014) Remote ischemic preconditioning reduces cardiac troponin I release in cardiac surgery: a meta-analysis [J]. J Cardiothorac Vasc Anesth 28:682–689
Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses [J]. BMJ 327:557–560
Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis [J]. Stat Med 21:1539–1558
Freiha FS (1977) Preoperative bowel preparation in urologic surgery. J Urol 118(6):955–956
Rollins KE, Javanmard-Emamghissi H, Lobo DN (2018) Impact of mechanical bowel preparation in elective colorectal surgery: a meta-analysis. World J Gastroenterol 24(4):519–536
Jung B, Matthiessen P, Smedh K et al (2010) Mechanical bowel preparation does not affect the intramucosal bacterial colony count. Int J Colorectal Dis 25(4):439–442
Santos J, Batista J, Sirimarco MT et al (1994) Prospective randomized trial of mechanical bowel preparation in patients undergoing elective colorectal surgery. Br J Surg 81(11):1673–1676
Platell C, Hall J (1998) What is the role of mechanical bowel preparation in patients undergoing colorectal surgery? Dis Colon Rectum 41(7):875–882
Yang L, Chen HS, Welk B et al (2013) Does using comprehensive preoperative bowel preparation offer any advantage for urinary diversion using ileum? A meta-analysis. Int Urol Nephrol 45(1):25–31
Deng S, Dong Q, Wang J et al (2014) The role of mechanical bowel preparation before ileal urinary diversion: a systematic review and meta-analysis [J]. Urol Int 92(3):339–348
Rk B, Hw H (2012) Campbell’s urology. Saunders, Philadelphia
Witjes JA, Bruins M, Cathomas E et al Guidelines associates. In: Linares E, Espinós M, Rouanne Neuzillet Y (eds) Guidelines on muscle-invasive and metastatic bladder cancer. The Netherlands: European association of urology. https://uroweb.org/guideline/bladder-cancer-muscle-invasive-and-metastatic/#7. Accessed 20 Feb 2020
Holte K, Nielsen KG, Madsen JL et al (2004) Physiologic effects of bowel preparation. Dis Colon Rectum 47:1397–1402
Bretagnol F, Alves A, Ricci A et al (2007) Rectal cancer surgery without mechanical bowel preparation. Br J Surg 94(10):1266–1271
Choi NK, Lee J, Chang Y et al (2013) Polyethylene glycol bowel preparation does not eliminate the risk of acute renal failure: a population based case-crossover study. Endoscopy 45(3):208–213
Cao F, Li J, Li F (2012) Mechanical bowel preparation for elective colorectal surgery: updated systematic review and meta-analysis. Int J Colorectal Dis 27(6):803–810
Guenaga KF, Matos D, Wille-Jorgensen P (2011) Mechanical bowel preparation for elective colorectal surgery. Cochrane Database Syst Rev 2011(9):Cd001544. https://doi.org/10.1002/14651858.CD001544.pub4
Zhu QD, Zhang QY, Zeng QQ, Yu ZP, Tao CL, Yang WJ (2010) Efficacy of mechanical bowel preparation with polyethylene glycol in prevention of postoperative complications in elective colorectal surgery: a meta-analysis. Int J Colorectal Dis 25(2):267–275
Dolejs SC, Guzman MJ, Fajardo AD et al (2017) Bowel preparation is associated with reduced morbidity in elderly patients undergoing elective colectomy. J Gastrointest Surg 21(2):372–379
Zhao T, Huang L, Tian Y et al (2014) Is it necessary to insert nasogastric tube routinely after radical cystectomy with urinary diversion? A meta-analysis. Int J Clin Exp Med 7(12):4627–4634
Scarborough JE, Mantyh CR, Sun Z et al (2015) Combined mechanical and oral antibiotic bowel preparation reduces incisional surgical site infection and anastomotic leak rates after elective colorectal resection: an analysis of colectomy-targeted ACS NSQIP. Ann Surg 262(2):331–337
Morris MS, Graham LA, Chu DI et al (2015) Oral antibiotic bowel preparation significantly reduces surgical site infection rates and readmission rates in elective colorectal surgery. Ann Surg 261(6):1034–1040
Funding
The study was supported by the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZY2016104) and Pillar Program from Department of Science and Technology of Sichuan Province (2018SZ0219).
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Feng, D., Li, X., Liu, S. et al. A comparison between limited bowel preparation and comprehensive bowel preparation in radical cystectomy with ileal urinary diversion: a systematic review and meta-analysis of randomized controlled trials. Int Urol Nephrol 52, 2005–2014 (2020). https://doi.org/10.1007/s11255-020-02516-9
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DOI: https://doi.org/10.1007/s11255-020-02516-9