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In-hospital mortality in elderly patients with acute kidney injury requiring dialysis: a cohort analysis

  • Nephrology - Original Paper
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Abstract

Objective

To determine risk factors for in-hospital mortality in elderly patients with acute kidney injury (AKI) requiring dialysis.

Introduction

AKI requiring dialysis is frequent in elderly and is associated with an increased intra-hospital mortality. With the growing number of older individuals among hospitalized patients with AKI demands a thorough investigation of the factors that contribute to their mortality to improve outcomes.

Methods

We performed a retrospective analysis of patients older than 80 years, admitted due to AKI requiring dialysis between January 2016 and December 2017. Patients who need intensive-care units (ICU) admission were excluded. The primary outcome was all-cause in-hospital mortality.

Results

A total of 154 patients were evaluated. The mean age was 85.3 ± 4.0 years and 76 patients (49.4%) were male. The overall mortality rate was 26.6%. On the multivariate analysis, serum albumin (OR 0.42 [95% CI 0.21–0.85], p 0.016), C reactive protein/albumin ratio (OR 1.04 [95% CI 0.99–1.09], and renal function recovery (OR 018 [95% CI 0.49–0.65], p 0.009) were the factors associated with higher in-hospital mortality.

Conclusions

Lower albumin level, higher C reactive protein/albumin ratio at admission, and absence of renal function recovery are associated with increased in-hospital mortality’s risk in elderly with acute kidney injury requiring dialysis.

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Authors and Affiliations

  1. Division of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Universitário Lisboa Norte, EPE, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal

    Inês Duarte, Joana Gameiro, Cristina Resina & Cristina Outerelo

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  1. Inês Duarte
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Duarte, I., Gameiro, J., Resina, C. et al. In-hospital mortality in elderly patients with acute kidney injury requiring dialysis: a cohort analysis. Int Urol Nephrol 52, 1117–1124 (2020). https://doi.org/10.1007/s11255-020-02482-2

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