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The prognostic effect of immunoscore in patients with clear cell renal cell carcinoma: preliminary results

  • Urology - Original Paper
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Abstract

Purpose

This study aimed to evaluate the density of CD8+ and CD3+ tumor-infiltrating lymphocytes (TILs) and determine whether the immunoscore has any prognostic effect on the oncological outcomes in patients with clear cell renal cell carcinoma (RCC).

Materials and methods

A total of 129 patients diagnosed with clear cell RCC following radical or partial nephrectomy between 2009 and 2014 were retrospectively analyzed. Both tumor core (CT) and the invasive margin of nephrectomy specimens were assessed. The specimens were immunostained for anti-CD8+ and anti-CD3+ TILs. The patients were divided into three groups (favorable, intermediate, and poor risk) according to immunoscore levels.

Results

In the multivariate analysis, a favorable immunoscore (I3–4) was associated with prolonged disease-free survival (DFS), progression-free survival (PFS), and overall survival (OS) (HR 2.652, 2.848, and 2.933, respectively; all p < 0.001). The lower Fuhrman grade and pathological tumor-node-metastasis (TNM) stage had better DFS, PFS, and OS, whereas prolonged PFS was associated with a higher density of CD8+ CT (HR 1.602, 95% CI 0.934–3.470; p = 0.014). The shorter DFS, PFS, and OS were observed in the group with poor immunoscore (I0–1) at the early TNM stage of RCC (p < 0.001). In the metastatic subgroup analysis, the immunoscore showed better estimation than the International Metastatic RCC Database Consortium model and the Memorial Sloan-Kettering Cancer Center risk model for progression and OS (p < 0.001).

Conclusion

The additional contributions of immunoscore to TNM stage, Fuhrman grade, and the WHO/ISUP 2016 grade for estimating oncological outcomes were found in ROC analysis. According to our preliminary results, immunoscore can be a promising prediction tool in clear cell RCC for postoperative oncological outcomes following nephrectomy.

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Funding

This work is financially supported by Health Science University Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital through the scientific research fund with the decision of dated 03.11.2017 and numbered 1.

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Authors and Affiliations

  1. Department of Urology, Karabük University Training and Research Hospital, 78200, Karabük, Turkey

    Ismail Selvi

  2. Department of Medical Oncology, Health Science University Dr, Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey

    Umut Demirci

  3. Department of Pathology, Health Science University Dr, Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey

    Nazan Bozdogan

  4. Department of Urology, Health Science University Dr, Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey

    Halil Basar

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  1. Ismail Selvi
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  2. Umut Demirci
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  4. Halil Basar
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Contributions

IS: conception and design, acquisition of data, statistical analysis, analysis and interpretation of data, and drafting of the manuscript. UD: conception and design, and critical revision of the manuscript for important intellectual content. NB: analysis and interpretation of data, pathological evaluation, and critical revision of the manuscript for important intellectual content. HB: critical revision of the manuscript for important intellectual content.

Corresponding author

Correspondence to Ismail Selvi.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval for research involving human participants

The study was approved by the local ethics committee (the protocol number: 2018-02/18; the date of approval: February 7, 2018) at Health Science University Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital. All procedures performed in our study involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informal written informed consent was obtained from all individual participants included in the study. The data of patients who did not consent were not used.

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Institution where the work was developed, city and country: Health Science University Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.

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Selvi, I., Demirci, U., Bozdogan, N. et al. The prognostic effect of immunoscore in patients with clear cell renal cell carcinoma: preliminary results. Int Urol Nephrol 52, 21–34 (2020). https://doi.org/10.1007/s11255-019-02285-0

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  • DOI: https://doi.org/10.1007/s11255-019-02285-0

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