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Adiponectin is related to markers of endothelial dysfunction and neoangiogenesis in diabetic patients

  • Nephrology - Original Paper
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Abstract

Purpose

Adiponectin an adipokine, produced by mature adipocyte, has an important effect on several aspects of endothelial function, including leukocyte adhesion (mediated by adhesion molecules like intercellular adhesion molecule 1 (ICAM1) endothelial cell selective adhesion molecule ESAM). Recently, it has been linked to vascular endothelial growth factor (VEGF)-modulated angiogenesis. ESAM might also be involved in modulating VEGF-dependent actions. We studied relationship of adiponectin to ESAM, ICAM1, and VEGF in type 2 diabetic patients (T2DP) with or without microvascular complications.

Methods

Incident T2DP referred for nephrologic evaluation were included (patients with no nephropathy or stage 1–4 nephropathy). T2DP with stage 5 chronic kidney disease (CKD) were selected from a dialysis center. Clinical, standard laboratory assessment and adiponectin, ESAM, ICAM1, and VEGF (ELISA) were recorded.

Results

Eighty-seven patients were included, 15 had no CKD, 30 with stage 1 or 2 CKD, 20 with stage 3 or 4 CKD and 22 patients on dialysis. ESAM was higher in patients with CKD than in those without CKD (p = 0.02), adiponectin, ICAM1, and VEGF were similar. Adiponectin correlated in univariate analysis to ESAM (r = 0.32, p = 0.002), ICAM1 (r = 0.23, p = 0.038), and CRP (r = 0.31, p = 0.012), and inversely to serum albumin (r = − 0.57, < 0.0001). In predialysis patients, adiponectin also correlated to albuminuria (r = 0.54, p < 0.0001) and glomerular filtration rate (r = − 0.46, p = 0.0001). In multivariate regression ESAM (p = 0.04), VEGF (p = 0.03), and albumin (p < 0.0001) are significant predictors of adiponectin. None of these cytokines were different when comparing patients with and without retinopathy.

Conclusion

Adiponectin is directly linked to adhesion molecules and VEGF in T2DP.

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Funding

Baseline evaluation was founded by CNCSIS Romania Idei 1167/2008 Grant.

Author information

Authors and Affiliations

  1. “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, 8 Victor Babes Street, 400000, Cluj-Napoca, Romania

    Teodor Kacso & Alexandra Maria Gavrilas

  2. Department of Informatics and Biostatistics, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, 6 Pasteur Street, 400349, Cluj-Napoca, Romania

    Cosmina Ioana Bondor

  3. Department of Nephrology, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, 3-5 Clinicilor Street, 400006, Cluj-Napoca, Romania

    Crina Claudia Rusu, Diana Moldovan, Dacian Trinescu, Laura Anca Coman, Maria Ticala & Alina Ramona Potra

Authors
  1. Teodor Kacso
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  2. Cosmina Ioana Bondor
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Corresponding author

Correspondence to Alexandra Maria Gavrilas.

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All authors declared that they have no conflicts of interest.

Ethical approval

The study was in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments; all included patients signed an informed consent.

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Kacso, T., Bondor, C.I., Rusu, C.C. et al. Adiponectin is related to markers of endothelial dysfunction and neoangiogenesis in diabetic patients. Int Urol Nephrol 50, 1661–1666 (2018). https://doi.org/10.1007/s11255-018-1890-1

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  • DOI: https://doi.org/10.1007/s11255-018-1890-1

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