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Relationship between plasma pentraxin 3 level and risk of chronic kidney disease in the Korean elderly: the Dong-gu study

  • Nephrology – Original Paper
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Abstract

Purpose This study investigated the cross-sectional association between chronic kidney disease (CKD) and plasma pentraxin 3 (PTX3) levels in a Korean population, in a community-based cohort study.

Methods

A total of 1816 (891 men, 925 women) subjects were randomly selected from the cohort of participants for the final analyses. Plasma PTX3 concentration was determined using enzyme-linked immunosorbent assays. The participants were divided into four quartiles according to the PTX3 levels. Multivariate logistic regression was performed to evaluate the association between plasma PTX3 level and CKD. Covariates inserted into the multivariate model included smoking status, systolic blood pressure, body mass index, waist circumference, high-density lipoprotein, low-density lipoprotein uric acid, white blood cell count, and carotid intima-media thickness.

Results

Compared to the lowest PTX3 group (Q1), a significantly higher risk of CKD was found in the highest group (Q4), with an odds ratio of 1.58 and 95% confidence interval of 1.18–2.11 (P for trend <0.001).

Conclusions

This study showed that higher plasma PTX3 levels are significantly associated with CKD risk. The biological mechanism remains unclear; therefore, further molecular investigation of association between CKD and PTX3 is needed.

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Authors and Affiliations

  1. Department of Preventive Medicine, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 501-746, Korea

    Ran Lee, Min-Ho Shin & Sun-Seog Kweon

  2. Center for Creative Biomedical Scientists, Chonnam National University, 160 Baekseo-ro, Dong-gu, Gwangju, Korea

    Min-Ho Shin & Hee-Nam Kim

  3. Department of Preventive Medicine and Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, 460 Iksandae-ro, Iksan, Korea

    Young-Hoon Lee

  4. Department of Preventive Medicine, Chosun University Medical School, 375 Seosuk-dong, Gwangju, Korea

    Seong-Woo Choi

  5. Department of Nursing, Nambu University, 23 Cheomdanjungang-ro, Gwangsan-gu, Gwangju, Korea

    Hye-Ran Ahn

  6. Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun, Jeonnam, Korea

    Sun-Seog Kweon

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  1. Ran Lee
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Correspondence to Sun-Seog Kweon.

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All authors declare that he/she has no conflict of interests regarding the publication of this paper.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by Institutional Review Board of Chonnam National University Hospital.

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Lee, R., Shin, MH., Kim, HN. et al. Relationship between plasma pentraxin 3 level and risk of chronic kidney disease in the Korean elderly: the Dong-gu study. Int Urol Nephrol 49, 2027–2033 (2017). https://doi.org/10.1007/s11255-017-1662-3

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