Abstract
Chronically reduced glomerular filtration rate (GFR) in old people does not always mean that they suffer from chronic kidney disease (CKD) since their GFR can just be reduced by aging. The HUGE equation has been recently described and validated in Spain for screening CKD without taking into account the patient’s GFR value. This equation is based on patient’s hematocrit, plasma urea levels and gender. The present study documented that the HUGE equation had and acceptable performance for screening CKD in elderly Argentine patients.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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Appendix [4]
Appendix [4]
CKD diagnosis: to have at least an abnormal value in one of the following parameters: GFR, urinalysis and renal ultrasound.
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Reduced GFR: a GFR value lower than the expected one secondary to aging: expected GFR = 130 − age (ml/min/1.73 m2).
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Abnormal urinalysis: presence of renal (dysmorphic) hematuria (>3 red blood cells) and/or proteinuria (>0.2 g/day).
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Abnormal renal ultrasound: presence of at least one of the following alterations in renal parenchyma: reduced size, asymmetry, increased parenchyma echogenicity, many cysts and altered cortex–medulla proportion.
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Musso, C.G., de los Rios, E., Vilas, M. et al. The HUGE formula (hematocrit, urea, gender) for screening for chronic kidney disease in elderly patients: a study of diagnostic accuracy. Int Urol Nephrol 49, 677–680 (2017). https://doi.org/10.1007/s11255-016-1486-6
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DOI: https://doi.org/10.1007/s11255-016-1486-6