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Tissue advanced glycation end products (AGEs), measured by skin autofluorescence, predict mortality in peritoneal dialysis

  • Nephrology - Original Paper
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Abstract

Purpose

The relation between tissue AGEs and mortality in end-stage renal disease (ESRD) is documented, but only in hemodialysis (HD) patients. This study aimed to measure and compare tissue AGEs levels in patients receiving either HD or peritoneal dialysis (PD) and to study the effect of these products on all-cause, cardiovascular or sepsis-related mortality.

Methods

Tissue AGEs were noninvasively assessed in 304 dialysis patients (202 on chronic HD and 102 on continuous ambulatory PD) by measuring skin autofluorescence using a validated Autofluorescence Reader (AGE Reader, DiagnOptics b.v., Groningen, The Netherlands).

Results

There was no difference in regard to AGEs levels between the HD (3.6 ± 0.8 AU)- and PD (3.5 ± 0.7 AU, p = 0.2)-treated patients. Diabetic patients had higher AGEs values in the HD group (3.97 ± 0.81 vs. 3.52 ± 0.77, p = 0.002), but not in the PD group (3.68 ± 0.6 vs. 3.45 ± 0.70, p = 0.26). In PD patients, increasing AGEs levels were associated with an elevated risk of all-cause mortality (a 2.09-fold increase for each increment of 1 AU in AGEs values) and sepsis (a 3.44-fold increase for each increment of 1 AU in AGEs values)-related mortality. Performing a similar analysis in diabetic patients, AGEs was associated only with sepsis-related mortality (a 3.08-fold increase for each increment of 1 AU in AGEs values).

Conclusions

This is the first study that demonstrates a relationship between tissue AGEs levels and sepsis-related mortality in PD-treated or diabetic ESRD patients. Future studies are necessary to evaluate the non-cardiovascular effects of tissue AGEs in ESRD patients.

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Acknowledgments

This study has been partially funded by IDEI PN-II-ID-PCE-2011-3-0637 Grant and the University of Medicine and Pharmacy Iasi Grant No. 1640/01.02.2013.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Nephrology, Gr. T. Popa University of Medicine and Pharmacy, Iasi, Romania

    Dimitrie Siriopol, Simona Hogas, Gabriel Veisa, Irina Mititiuc, Carmen Volovat, Mugurel Apetrii, Mihai Onofriescu, Irina Busila, Mihaela Oleniuc & Adrian Covic

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  1. Dimitrie Siriopol
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  2. Simona Hogas
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Correspondence to Dimitrie Siriopol.

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Siriopol, D., Hogas, S., Veisa, G. et al. Tissue advanced glycation end products (AGEs), measured by skin autofluorescence, predict mortality in peritoneal dialysis. Int Urol Nephrol 47, 563–569 (2015). https://doi.org/10.1007/s11255-014-0870-3

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  • DOI: https://doi.org/10.1007/s11255-014-0870-3

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