Skip to main content

Advertisement

SpringerLink
Log in

The impact of abdominal aortic calcification and visceral fat obesity on lower urinary tract symptoms in patients with benign prostatic hyperplasia

  • Urology - Original Paper
  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Objectives

To investigate the impact of abdominal aortic calcification and visceral fat area (VFA) on lower urinary tract symptoms (LUTS) and clinical parameters in patients with benign prostatic hyperplasia (BPH).

Methods

We retrospectively studied 250 patients with LUTS associated with BPH. Each participant was examined with routine examination including measurement of various data; (1) voided volume (VV), maximum urinary flow rate on free uroflowmetry, (2) postvoid residual urine volume and prostate volume using transabdominal ultrasound, (3) International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS), and (4) aortic calcification index (ACI) and VFA were measured by abdominal CT.

Results

Mean age of the patients was 72.4 ± 9.6 years. ACI significantly correlated with VV (P = 0.0392) and tended to correlate with maximum urinary flow rate, while ACI did not correlate with subjective symptoms. VFA significantly correlated with nocturia score of IPSS (P = 0.0177) and frequency score of OABSS (P = 0.0166) and tended to correlate with urgency score of IPSS and maximum urinary flow rate.

Conclusions

Aortic calcification index (ACI) correlated with only objective parameters, while VFA correlated with only storage symptoms. This study suggested that abdominal aortic calcification and VFA have certain influence on LUTS and clinical parameters in patients with BPH.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Abbreviations

MetS:

Metabolic syndrome

LUTS:

Lower urinary tract symptoms

BPH:

Benign prostatic hyperplasia

OAB:

Overactive bladder symptom

ACI:

Aortic calcification index

VFA:

Visceral fat area

IPSS:

International Prostatic Symptom Score

OABSS:

Overactive Bladder Symptom Score

PV:

Prostate volume

BMI:

Body mass index

BBF:

Bladder blood flow

References

  1. Parsons JK, Sarma AV, McVary K, Wei JT (2009) Obesity and benign prostatic hyperplasia: clinical connections, emerging etiological paradigms and future directions. J Urol 182:S27–S31

    Article  PubMed  Google Scholar 

  2. Kirby MG, Wagg A, Cardozo L et al (2010) Overactive bladder: is there a link to the metabolic syndrome in men? Neurourol Urodyn 29:1360–1364

    Article  PubMed  Google Scholar 

  3. Alvarez GE, Alvarez GE, Beske SD et al (2002) Sympathetic neural activation in visceral obesity. Circulation 106:2533–2536

    Article  PubMed  Google Scholar 

  4. McVary KT, Rademaker A, Lloyd GL, Gann P (2005) Autonomic nervous system overactivity in men LUTS secondary to BPH. J Urol 174:1327–1333

    Article  PubMed  Google Scholar 

  5. Matsumoto S, Kakizaki H (2012) Causative significance of bladder blood flow in lower urinary tract symptoms. Int J Urol 19:20–25

    Article  PubMed  Google Scholar 

  6. Ponholzer A, Temml C, Wehrberger C et al (2006) The association between vascular risk factors and LUTS in both sexes. Eur Urol 50:581–586

    Article  PubMed  Google Scholar 

  7. Azadzoi KM, Tarcan T, Kozlowski R et al (1999) Overactivity and structural changes in the chronically ischemic bladder. J Urol 162:1768–1778

    Article  PubMed  CAS  Google Scholar 

  8. Yoshida M, Masunaga K, Nagata T et al (2010) The effects of chronic hyperlipidemia on bladder function in myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits. Neurourol Urodyn 29:1350–1354

    Article  PubMed  Google Scholar 

  9. Nomiya M, Yamaguchi O, Andersson KE et al (2012) The effect of atherosclerosis-induced chronic bladder ischemia on bladder function in rats. Neurourol Urodyn 31:195–200

    Article  PubMed  CAS  Google Scholar 

  10. Nomiya M, Sagawa K, Yazaki J et al (2012) Increased bladder activity is associated with elevated oxidative stress markers and proinflammatory cytokines in a rat model of atherosclerosis-induced chronic bladder ischemia. Neurourol Urodyn 31:185–189

    Article  PubMed  CAS  Google Scholar 

  11. Motoya T, Matsumoto S, Yamaguchi S et al (2011) Visceral fat is a significant risk factor of storage symptoms in patients with BPH/LUTS. In: Proceedings of the 41st annual meeting of the International Continence Society, Glasgow, UK, abstract no. 421, p 112

  12. Matsumoto S, Wada N, Motoya T et al (2011) The impact of abdominal aortic calcification and visceral fat obesity on bladder blood flow and lower urinary tract symptoms in patients with benign prostatic hyperplasia. In: Proceedings of the 41st annual meeting of the International Continence Society, Glasgow, UK, abstract no. 301, p 104

  13. Homma Y, Yoshida M, Seki N et al (2006) Symptom assessment tool for overactive bladder syndrome—overactive bladder symptom score. Urology 68:318–323

    Article  PubMed  Google Scholar 

  14. Yamaguchi O, Nishizawa O, Takeda M et al (2009) Clinical guidelines for overactive bladder. Int J Urol 16:126–142

    Article  PubMed  CAS  Google Scholar 

  15. Nitta K, Akiba T, Uchida K et al (2003) The progression of vascular calcification and serum osteoprotegerin levels in patients on long-term hemodialysis. Am J Kidney Dis 42:303–309

    Article  PubMed  CAS  Google Scholar 

  16. Ohashi N, Yamamoto H, Horiguchi J et al (2009) Visceral fat accumulation as a predictor of coronary artery calcium as assessed by multislice computed tomography in Japanese patients. Atherosclerosis 202:192–199

    Article  PubMed  CAS  Google Scholar 

  17. Mariappan P, Chong WL (2006) Prevalence and correlations of lower urinary tract symptoms, erectile dysfunction and incontinence in men from a multiethnic Asian population: results of a regional population-based survey and comparison with industrialized nations. BJU Int 98:264–268

    Google Scholar 

  18. Seim A, Hoyo C, Ostbye T, Vatten L (2005) The prevalence and correlates of urinary tract symptoms in Norwegian men: the HUNT study. BJU Int 96:88–92

    Article  PubMed  Google Scholar 

  19. Joseph MA, Harlow SD, Wei JT et al (2003) Risk factors for lower urinary tract symptoms in a population-based sample of African-American men. Am J Epidemiol 157:906–914

    Article  PubMed  Google Scholar 

  20. Wong SY, Woo J, Hong A et al (2006) Risk factors for lower urinary tract symptoms in southern Chinese men. Urology 68:1009–1014

    Article  PubMed  Google Scholar 

  21. Tomita K, Mizoue T, Matsumoto T (2009) Lower urinary tract symptoms in relation to lifestyle and medical conditions in Japanese workers. Int J Urol 16:493–498

    Article  PubMed  Google Scholar 

  22. Pinggera GM, Mitterberger M, Steiner E et al (2008) Association of lower urinary tract symptoms and chronic ischaemia of the lower urinary tract in elderly women and men: assessment using colour Doppler ultrasonography. BJU Int 102:470–474

    Article  PubMed  Google Scholar 

  23. Bartsch G, Strasser H, De EJ et al (2008) Pelvic ischemia is measurable and symptomatic in patients with coronary artery disease: a novel application of dynamic contrast-enhanced magnetic resonance imaging. J Sex Med 5:2635–2645

    Article  Google Scholar 

  24. Wada N, Watanabe M, Kita M et al (2012) Analysis of bladder vascular resistance before and after prostatic surgery in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction. Neurourol Urodyn 31:659–663

    Article  PubMed  Google Scholar 

  25. Tarcan T, Azadzoi KM, Siroky MB et al (1998) Age-related erectile and voiding dysfunction: the role of arterial insufficiency. Br J Urol 82(Suppl. 1):26–33

    Article  PubMed  Google Scholar 

  26. Takahashi N, Shishido K, Sato Y et al (2012) The association between severity of atherosclerosis and lower urinary tract function in male patients with lower urinary tract symptoms. LUTS 4:9–13

    Google Scholar 

  27. Kaplan SA (2006) Male pelvic health: a urological call to arms. J Urol 176:2351–2352

    Article  PubMed  Google Scholar 

  28. Rohrmann S, Smit E, Giovannucci E, Platz EA (2004) Associations of obesity with lower urinary tract symptoms and noncancer prostate surgery in the Third National Health and Nutrition Examination Survey. Am J Epidemiol 159:390–397

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the Grants for the 11th AKUA (Asahi Kasei Pharma Urological Academy) Research Foundation. We would like to thank Ms. Fuyumi Onodera for secretarial assistance.

Conflict of interest

None declared.

Author information

Author notes

  1. Satoshi Yamaguchi

    Present address: Department of Urology, Kitasaito Hospital, Asahikawa, Hokkaido, Japan

Authors and Affiliations

  1. Department of Renal and Urologic Surgery, Asahikawa Medical University, 2-1-1-1, Midorigaoka-Higashi, Asahikawa, Hokkaido, 078-8510, Japan

    Tadasu Motoya, Seiji Matsumoto, Naoki Wada & Hidehiro Kakizaki

  2. Department of Urology, Hokkaido Social Welfare Association Furano Hospital, Furano, Hokkaido, Japan

    Tadasu Motoya, Satoshi Yamaguchi, Atsushi Numata & Hiroaki Osanai

Authors
  1. Tadasu Motoya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Seiji Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Satoshi Yamaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Naoki Wada
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Atsushi Numata
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hiroaki Osanai
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hidehiro Kakizaki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Seiji Matsumoto.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Motoya, T., Matsumoto, S., Yamaguchi, S. et al. The impact of abdominal aortic calcification and visceral fat obesity on lower urinary tract symptoms in patients with benign prostatic hyperplasia. Int Urol Nephrol 46, 1877–1881 (2014). https://doi.org/10.1007/s11255-014-0757-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11255-014-0757-3

Keywords

Search

Navigation